European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 205, P. 106989 - 106989
Published: Dec. 14, 2024
Language: Английский
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 2, 2024
Abstract Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies constructing phototheranostic systems by engineering integration photosensitizers (PSs) into nanosystems, nano‐PSs face challenges including complexity in preparation process, low delivery efficiency, and toxicity issues. Contrastingly, burgeoning popularity small molecule PSs characterized aggregation‐induced emission (AIE) become evident arena phototheranostics. This preference is underscored their well‐defined structures, adjustable photophysical properties, toxicity. Therefore, acquiring profound insights pioneering strides achievable through a solitary PS with AIE tumor phototheranostics paramount scientific significance. In this review, we will discuss recent progress properties diagnosis phototherapies representative examples, guided ethos “Complexity made easy”. We also look forward future development direction molecules, central objective advancing research focal emphasis on simplicity, expeditiousness, safety.
Language: Английский
Citations
11
Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(7), P. 1737 - 1755
Published: Feb. 8, 2024
Language: Английский
Citations
8
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(18)
Published: April 3, 2024
Ferroptosis is identified as a potential target for anticancer therapy. However, most conventional ferroptosis inducers not only fail to trigger intracellular lipid peroxidation storm, but are also prone cause ferroptosis-related toxicity through off-target destruction of antioxidant defense systems. Therefore, potent and highly tumor-specific induction modality desired. Herein, self-cooperative nanomedicine imaging-guided photothermal ferrotherapy, which fabricated based on molecular nanoassembly (NA) DiR (a probe) ferrocene (Fc, reactant the Fenton reaction), elaborately exploited. DiR-elicited hyperthermia induces both therapy (PTT) significant acceleration kinetics Fc-involved reaction, collaboratively causing storm in tumor cells. In turn, plenty peroxides boost PTT downregulation heat shock protein 90. As expected, such NA demonstrates synergetic eradication 4T1 breast tumor-bearing mice xenograft model. This study offers novel nanotherapeutic paradigm precise multimodal cancer
Language: Английский
Citations
8
Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(4), P. 100892 - 100892
Published: Feb. 28, 2024
Small-molecule prodrug nanoassembly technology with a unique advantage in off-target toxicity reduction has been widely used for antitumor drug delivery. However, activation remains rate-limiting step exerting therapeutic actions, which requires to quickly reach the minimum valid concentrations of free drugs. Fortunately, we find that natural compound (BL-193) selectively improves chemotherapy sensitivity breast cancer cells podophyllotoxin (PPT) at ineffective dose concentrations. Based on this, propose combine sensitization fully unleash chemotherapeutic potential PPT. Specifically, redox-sensitive (PSSF) PPT is synthesized by coupling 9-fluorenyl-methanol (Fmoc-OH) linked via disulfide bond. Intriguingly, PSSF π-conjugated structure readily co-assembles BL-193 into stable nanoassembly. Significantly, serves as an excellent chemosensitizer creates ultra-low-dose window Moreover, design and precise hybrid well manage toxicity. As expected, such BL-193-empowered elicits potent responses. This study offers novel paradigm magnify efficacy-toxicity benefits.
Language: Английский
Citations
6
European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 279, P. 116928 - 116928
Published: Sept. 30, 2024
Language: Английский
Citations
4
ACS Nano, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 12, 2024
Main conventional antithrombotic therapies often suffer from unsatisfactory treatment outcomes and the risk of undesirable tissue hemorrhage. Deep clot penetration, on-demand drug activation, release within clots remain significant challenges. While past efforts to develop nanomedicines prodrugs have improved safety at expense therapeutic effects. Herein, we a self-piercing self-activating nanoassembly composed an oxidation-sensitive prodrug (TGL-S-Fmoc, TSF) ticagrelor (TGL) IR808 (a photothermal/photodynamic dual-effect photosensitizer). TSF readily coassembles with into carrier-free hybrid nanomedicine. Upon laser irradiation, enables photothermal thrombolysis deep penetration while also synergistically facilitating activation triggered by IR808-generated singlet oxygen (1O2) endogenous hydrogen peroxide clots. Following fibrin-targeting modification, achieves self-indicating thrombus-targeted accumulation, dual-priming inside-out thrombus ablation favorable in vivo. This study advances clinical translation nanomedicines.
Language: Английский
Citations
2
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 15, 2024
Abstract Clinical thrombus therapy continues to be challenged by unsatisfactory antithrombotic outcomes and high bleeding risk. Rational design of prodrugs for thrombolytic agents is expected ameliorate this situation. Nevertheless, a significant obstacle the inadequate penetration prodrug‐engineered nanomedicines, which hampers their effective interaction with excessive stimuli produced in thrombi, resulting suboptimal drug activation. Herein, clot‐piercing nanoassembly reported facilitate photothermal clot penetration, adaptable activation, anti‐inflammatory action, synergetic therapy, molecularly co‐assembled using photosensitizer reactive oxygen species (ROS)‐sensitive antiplatelet dimeric prodrug. The demonstrates multiple advantages, including facile fabrication, co‐loading capacity, long circulation time blood, thrombus‐targeting accumulation, photothermal‐potentiated deep on‐demand prodrug activation response H 2 O concentrations inside clots, anti‐inflammatory/antiplatelet synergy. These advantages result significantly enhanced efficacy vivo favorable safety. This study presents new paradigm development prodrug‐driven nanomedicines.
Language: Английский
Citations
1
Drug Delivery and Translational Research, Journal Year: 2023, Volume and Issue: 14(7), P. 1860 - 1871
Published: Dec. 12, 2023
Language: Английский
Citations
2
Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 31(8)
Published: Dec. 2, 2024
Abstract This study investigates the effect of chloride levels on mode action palladium complexes for activation propargyl‐ and allene‐protected fluorophores chemotherapeutic drugs through uncaging reactions. Four Pd(II) were synthesized characterized using various spectroscopic techniques to confirm their structure electronic properties. Kinetic studies density functional theory calculations revealed that ions in phosphate buffered saline (PBS) significantly enhance catalytic efficiency, particularly allenyl‐protected substrates compared propargylic counterparts. enhancement is attributed neutral charge nature Pd complex. The data suggest are less prone exchange by water molecules. Additionally, ligands counterbalance unusually high stability key σ‐bound η 1 ‐Pd intermediates aquo PB, leading an overall higher reactivity. These results highlight impact fine‐tuning properties metal center both designed environmental factors. Bench evaluations tests with living breast cancer cells demonstrated a catalyst complex bidentate ligand effectively activates prodrugs propargyl‐5‐fluorouracil (Prop‐5FU) allene‐5‐Fluorouracil (Alle‐5FU), latter being novel prodrug. successfully released active drug, inducing significant cytotoxicity, especially Alle‐5FU, which operates at lower concentrations than Pro‐5FU.
Language: Английский
Citations
0
European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 205, P. 106989 - 106989
Published: Dec. 14, 2024
Language: Английский
Citations
0