Translational Oncology, Journal Year: 2025, Volume and Issue: 56, P. 102386 - 102386
Published: April 18, 2025
Language: Английский
Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(12), P. 820 - 842
Published: Oct. 2, 2023
Language: Английский
Citations
64
Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)
Published: Jan. 25, 2023
Abstract Ovarian cancer (OC) is one of the most common gynecological malignancies with high morbidity and mortality. The peritoneum metastatic sites in ovarian cancer, involving large amounts ascites. However, its mechanism unclear. peritoneal microenvironment composed effusion creates favorable conditions for progression metastasis. Here, we reviewed metastasis patterns molecular mechanisms as well major components microenvironment, effusion, immune investigated relationship between
Language: Английский
Citations
44
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: March 22, 2024
Vaginal microbiota transplantation (VMT) is a cutting-edge treatment modality that has the potential to revolutionize management of vaginal disorders. The human vagina complex and dynamic ecosystem home diverse community microorganisms. These microorganisms play crucial role in maintaining health well-being female reproductive system. However, when balance this disrupted, it can lead development various Conventional treatments, such as antibiotics antifungal medications, temporarily relieve symptoms they often fail address underlying cause problem, which disruption microbiota. In recent years, VMT emerged promising therapeutic approach aims restore ecosystem. Several studies have demonstrated safety efficacy treating bacterial vaginosis, recurrent yeast infections, other conditions. procedure also shown results reducing risk sexually transmitted infections preterm birth pregnant women. more research needed establish optimal donor selection, preparation, screening protocols, well long-term efficacy. offers safe, effective, minimally invasive option for women with persistent problems. It could improve quality life millions worldwide become standard shortly. With further development, potentially treat wide range problems beyond scope
Language: Английский
Citations
14
Proteomes, Journal Year: 2024, Volume and Issue: 12(1), P. 8 - 8
Published: March 18, 2024
Ovarian cancer is one of the deadliest cancers in women. The lack specific symptoms, especially at initial stages disease development, together with malignancy heterogeneity, lower life expectancy patients. Aiming to improve survival rates, diagnostic and prognostic biomarkers are increasingly employed clinics, providing gynecologists oncologists new tools guide their treatment decisions. Despite vast number investigations, there still an urgent need discover more ovarian subtype-specific markers which could further patient classification. To this end, high-throughput screening technologies, like mass spectrometry, applied deepen tumoral cellular landscape describe malignant phenotypes. As for treatment, targeted therapies, such as those based on PARP inhibitors, have shown great efficacy destroying cells. Likewise, drug-nanocarrier systems targeting cells exhibited promising results. In narrative review, we summarize latest achievements pursuit recent anti-tumoral therapies.
Language: Английский
Citations
9
Cancer Letters, Journal Year: 2025, Volume and Issue: 612, P. 217410 - 217410
Published: Jan. 16, 2025
Language: Английский
Citations
1
Deleted Journal, Journal Year: 2025, Volume and Issue: 33(1), P. 200938 - 200938
Published: Jan. 18, 2025
Epithelial ovarian cancer (EOC) is the deadliest gynecological malignancy. Precision treatments are crucial for improving patient survival. This research explored potential anti-tumor effects of combining inetetamab and atezolizumab HER2+ EOC patients. The expressions human epidermal growth factor receptor 2 (HER2) programmed cell death ligand 1 (PD-L1) in cells were evaluated. cell-derived subcutaneous peritoneal dissemination mouse models used to evaluate inetetamab, with or without atezolizumab. correlations between HER2 PD-L1 as well infiltration T tumors from patients mice analyzed by immunohistochemistry. Inetetamab suppressed models. overexpression increased levels cells. expression level positively related that both CD4+ CD8+ combination impeded vivo induced a long-term effect elevated CD103+CD8+ These findings suggest could be promising precision treatment strategy
Language: Английский
Citations
1
Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 114 - 114
Published: Jan. 20, 2025
Oxidative stress is a state of imbalance between the production reactive oxygen species (ROS) and nitrogen (RNS) antioxidant defence system in body. may be associated with variety diseases, such as ovarian cancer, diabetes mellitus, neurodegeneration. The generation oxidative one common refractory malignancies among gynaecological tumours, several factors. On hand, increased metabolism cancer cells can lead to ROS, on other impaired not able effectively scavenge excessive ROS. In addition, chemotherapy radiotherapy elevate cells. cause damage, promote development even result drug resistance. Therefore, studying important for prevention treatment cancer. Antioxidants, markers stress, might serve strategies preventing treating this review, we will discuss complex relationship well role therapeutic potential antioxidants thus guiding future research clinical interventions.
Language: Английский
Citations
1
Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 69 - 69
Published: Jan. 21, 2025
Photodynamic therapy is a non-ionizing radiation treatment that utilizes photosensitizer in combination with light to produce singlet oxygen. This oxygen induces anti-cancer effects by causing apoptotic, necrotic, or autophagic cell death tumor cells. Currently, photodynamic employed oncology treat various cancers. In the presence of oxygen, this non-invasive approach leads direct death, damage microvasculature, and induction local inflammatory response. These allow be effective treating early-stage tumors, extending survival cases where surgery not feasible, significantly improving quality life. paper, we provide state art on cytomolecular mechanisms associated pathways involved therapy. By integrating these mechanistic insights most recent advancements nanotechnology, phototherapeutic has potential become prevalent option within conventional cancer therapies, enhancing its application precision medicine.
Language: Английский
Citations
1
Current Opinion in Immunology, Journal Year: 2023, Volume and Issue: 83, P. 102331 - 102331
Published: May 4, 2023
Language: Английский
Citations
20
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10479 - 10479
Published: June 22, 2023
Currently, ovarian cancer (OC) is a target of intense biomarkers research because its frequent late diagnosis and poor prognosis. Serum determination Human epididymis protein 4 (HE4) very important early detection test. Most interestingly, HE4 plays unique role in OC as it has been implicated not only but also the prognosis recurrence this lethal neoplasm, actually acting clinical biomarker. There are several evidence about predictive power clinically, conversely less described concerning oncogenesis. Based on these considerations, main goal review to clarify proliferation, angiogenesis, metastatization, immune response development targeted therapy. Through deeper understanding functions key molecule oncogenetic processes underlying OC, could be possibly considered an essential resource for therapy choice.
Language: Английский
Citations
18