Non-Coding RNA,
Journal Year:
2025,
Volume and Issue:
11(2), P. 27 - 27
Published: March 18, 2025
Metabolic
reprogramming
is
a
hallmark
of
cancer,
crucial
for
supporting
the
rapid
energy
demands
tumor
cells.
MYC,
often
deregulated
and
overexpressed,
key
driver
this
shift,
promoting
Warburg
effect
by
enhancing
glycolysis.
However,
there
remains
gap
in
understanding
mechanisms
factors
influencing
MYC's
metabolic
roles.
Recently,
non-coding
RNAs
(ncRNAs)
have
emerged
as
important
modulators
MYC
functions.
This
review
focuses
on
ncRNAs
that
regulate
MYC-driven
metabolism,
particularly
effect.
The
categorizes
these
into
three
main
groups
based
their
interaction
with
examines
behind
interactions.
Additionally,
we
explore
how
different
types
may
collaborate
or
influence
each
other's
roles
regulation
function,
aiming
to
identify
biomarkers
synthetic
lethality
targets
disrupt
cancer.
Finaly,
highlights
clinical
implications
ncRNAs,
providing
an
up-to-date
summary
potential
cancer
prognosis
therapy.
With
recent
advances
MYC-targeted
therapy
reaching
trials,
exciting
combining
therapies
ncRNA-based
strategies
holds
great
promise
treatment
efficacy.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 3, 2025
Progression
to
castration
resistance
is
the
leading
cause
of
death
in
prostate
cancer
patients.
Long
non-coding
RNAs
(lncRNAs)
have
recently
become
a
focal
point
regulation
development.
However,
few
lncRNAs
associated
with
castration-resistant
(CRPC)
been
reported.
Firstly,
we
explore
CRPC
by
RNA
sequencing
and
validated
using
quantitative
polymerase
chain
reaction
(qRT-PCR)
fluorescence
situ
hybridization
(RNA-FISH).
The
clinical
significance
FLJ
was
evaluated
collected
cohort.
Functional
loss
assays
were
performed
assess
effects
on
cells
both
vitro
vivo.
regulatory
mechanism
investigated
immunohistochemistry
(IHC),
qRT-PCR,
dual-luciferase
reporter
assays,
chromatin
immunoprecipitation
(ChIP)
assays.
highly
expressed
higher
stages
Gleason
scores
cancer.
strongly
positively
correlated
androgen
receptor
(AR),
which
acts
as
transcription
factor
directly
binds
promoter
region
enhance
its
transcription.
Knockdown
inhibits
cell
proliferation
increases
sensitivity
enzalutamide
(ENZA)
vitro.
Mechanistically,
promotes
inhibiting
AR
nuclear
import
cytoplasmic
protein
degradation,
thereby
activating
androgen-independent
signaling
pathway.
Importantly,
vivo
experiments
showed
that
knockdown
inhibited
tumor
growth
enhanced
therapeutic
effect
ENZA.
This
study
identifies
novel
lncRNA
progression.
Sustained
activation
upregulate
expression.
circumvents
traditional
androgen-dependent
survival
entry
Targeting
FLJ-AR
axis
may
represent
strategy
for
patients
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 6, 2025
Gastric
cancer
(GC)
is
one
of
the
most
common
malignancies.
Previous
studies
have
shown
that
mitochondrial
metabolism
associated
with
However,
relevant
research
on
mitochondria-related
lncRNAs
in
GC
lacking.
We
integrated
corresponding
information
patients
from
The
Cancer
Genome
Atlas
(TCGA)
database.
Mitochondria-related
were
selected
based
differential
expression
and
a
correlation
analysis
to
construct
prognostic
model.
mutation
data
analyzed
distinguish
differences
tumor
burden
(TMB).
Single-sample
gene
set
enrichment
(ssGSEA)
was
performed
evaluate
immunological
differences.
A
series
cell-based
experiments
adopted
biological
behavior
GC.
total
1571
identified.
signature
incorporating
nine
built
293
suitable
cases
could
predict
patient
prognosis.
TMB
ssGSEA
indicated
low-risk
group
displayed
increased
immune
function.
differentially
expressed
genes
enriched
metabolic
functions.
AC129507.1
significantly
upregulated
cells
poor
prognosis,
its
knockdown
inhibited
proliferation
migration
cells.
Mechanistically,
silencing
led
abnormal
glycolipid
oxidative
stress,
thus
inducing
ferroptosis.
Our
nine-lncRNA
risk
powerfully
promoted
malignant
phenotypes
play
nonnegligible
role
by
promoting
formation
immunosuppressive
microenvironment
inhibiting
initiation
ferroptosis,
which
needs
be
further
explored.
Trends in Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 1, 2024
Never
in
mitosis
A
(NIMA)-related
kinase
2
(NEK2)
is
a
serine/threonine
found
the
nucleus
and
cytoplasm
throughout
cell
cycle.
NEK2
overexpressed
many
cancers
biomarker
of
poor
prognosis.
Factors
contributing
to
elevation
cancer
cells
include
oncogenic
transcription
factors,
decreased
ubiquitination,
DNA
methylation,
circular
RNA
(circRNA)/long
noncoding
(lncRNA)-miRNA
axis.
overexpression
produces
chromosomal
instability
aneuploidy,
thereby
enhancing
progression
suppressing
antitumor
immunity,
which
highlights
prominence
tumorigenesis
tumor
progression.
Small-molecule
inhibitors
targeting
have
demonstrated
promising
therapeutic
potential
vitro
vivo
across
various
types.
This
review
outlines
regulatory
mechanisms
expression,
emphasizes
its
functional
roles
initiation
progression,
anticancer
properties
inhibitors.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 15, 2024
Liver
cancer
is
one
of
the
most
lethal
gastrointestinal
malignancies.
Emerging
evidence
has
underscored
pivotal
role
long
non-coding
RNAs
(lncRNAs)
in
tumorigenesis,
with
ST8SIA6-AS1
identified
as
a
novel
oncogenic
lncRNA
contributing
to
liver
progression.
consistently
upregulated
hepatic
tissues
and
strongly
associated
unfavorable
prognosis.
Moreover,
it
demonstrates
high
diagnostic
efficacy
detecting
HCC.
involved
various
cellular
processes
including
proliferation,
migration,
invasion,
primarily
through
its
function
competing
endogenous
RNA
(ceRNA),
thereby
facilitating
hepatocarcinogenesis
disease
advancement.
This
review
provides
detailed
examination
molecular
functions
regulatory
mechanisms
hepatocellular
carcinoma
(HCC)
highlights
potential
promising
biomarker
for
cancer,
aiming
propel
development
innovative
therapeutic
strategies
HCC
management.
Cancer Cell International,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Dec. 19, 2024
The
long
non-coding
RNA
HOTAIR
is
overexpressed
in
many
cancers
and
associated
with
several
cancer-promoting
effects,
including
increased
cell
proliferation,
migration
treatment
resistance.
levels
correlate
tumor
stage,
lymph
node
metastasis
overall
survival
patients
various
types
of
cancer.
This
highlights
the
potential
uses
HOTAIR,
early
cancer
detection,
predicting
patient
outcome,
identifying
high-risk
individuals
assisting
therapy
selection
monitoring.
aim
this
review
to
provide
a
comprehensive
summary
research
progress,
molecular
mechanisms
clinical
significance
human
cancers.
In
addition,
applications
such
as
targeted
therapy,
radiotherapy,
chemotherapy
immunotherapy,
are
discussed,
relevant
information
on
future
advances
provided.
