Oncology,
Journal Year:
2023,
Volume and Issue:
25(4), P. 255 - 261
Published: Jan. 1, 2023
Summary.
Hormone-dependent
malignant
neoplasms
are
the
most
common
form
of
breast
cancer
(BC)
worldwide.
The
high
heterogeneity
clinical
manifestations
and
response
to
treatment
indicates
need
search
for
prognostic
predictive
markers
predict
aggressiveness
course
hormone-dependent
BC
prescribe
individualized
tactics.
MicroRNAs
short
RNA
molecules
that
play
an
important
role
in
regulating
expression
many
genes.
This
is
due
fact
miRNAs
modulators
growth,
differentiation
metastasis
various
histogenesis,
including
BC.
can
be
used
disease
choose
optimal
tactics,
since
their
levels
determined
not
only
tumor
tissue
but
also
blood
serum.
systematization
generalization
results
our
own
research
data
from
literature
on
possibility
using
miRNA
as
perceptiveness
monitor
process
determine
sensitivity
tumors
neoadjuvant
hormonal
therapy.
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics,
Journal Year:
2023,
Volume and Issue:
32(2), P. 241 - 249
Published: Dec. 7, 2023
Breast
cancer
has
surpassed
lung
to
become
the
most
common
malignancy
worldwide.
The
incidence
rate
and
mortality
of
breast
continue
rise,
which
leads
a
great
burden
on
public
health.
Circular
RNAs
(circRNAs),
new
class
noncoding
(ncRNAs),
have
been
recognized
as
important
oncogenes
or
suppressors
in
regulating
initiation
progression.
In
cancer,
circRNAs
significant
roles
tumorigenesis,
recurrence
multidrug
resistance
that
are
mediated
by
various
mechanisms.
Therefore,
may
serve
promising
targets
therapeutic
strategies
for
management.
This
study
reviews
recent
studies
about
biosynthesis
characteristics
diagnosis,
treatment
prognosis
evaluation,
well
value
clinical
applications
biomarkers
cancer.
Understanding
mechanisms
function
could
help
transform
basic
research
into
facilitate
development
novel
circRNA-based
treatment.
Breast Cancer Research,
Journal Year:
2023,
Volume and Issue:
25(1)
Published: July 17, 2023
Chemoresistance
involves
metastasis
and
aggressiveness
of
breast
cancer
(BC).
Chemotherapy-elicited
exosomes
have
been
reported
to
be
associated
with
drug
resistance
pro-metastatic
capacity
BC
cells.
Non-coding
RNAs
(ncRNAs)
are
enriched
in
exosomes,
which
participated
generation,
progression,
BC.
However,
the
mechanism
underlying
chemoresistance
cells
mediated
by
BC-derived
exosomal
ncRNAs
remained
elucidated.The
effects
PTX-induced
circBACH1
on
cell
function
were
assessed
using
RNA
Binding
Protein
Immunoprecipitation
(RIP),
dual
luciferase
reporter
gene,
tube
formation,
CCK-8,
Western
Blot
assays.
The
miR-217
expression
levels
detected
quantitative
real-time
PCR
(RT-qPCR)
Immunohistochemistry
(IHC)
assays
tissues
precancerous
patients.CircBACH1
was
increased
paclitaxel-treated
(PTX-EXO)
tissue.
PTX-EXO
shown
promote
PTX-resistance
angiogenesis
through
upregulation
circBACH1.
Downregulation
improved
PTX-sensitiveness
suppressing
viability,
stemness,
migration,
Moreover,
we
found
that
interacted
targeted
GTPase-activating
SH3
domain-binding
protein
2
(G3BP2)
CircBACH1
combined
cotransfection
suppressed
G3BP2
proteins
compared
treatment
MCF-7
In
addition,
downregulation
migration.These
results
demonstrated
promoted
stemness
migration
sponging
upregulate
G3BP2,
provided
a
new
therapeutic
target
for
progression
via
circBACH1/miR-217/G3BP2
axis.
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(7)
Published: July 31, 2023
Abstract
Dysregulated
ERα
signaling
is
responsible
for
endocrine
resistance
and
eventual
relapse
in
patients
with
estrogen
receptor-positive
(ER
+
)
breast
cancer.
Thus,
identifying
novel
regulators
necessary
to
fully
understand
the
mechanisms
of
resistance.
Here,
we
identified
circRNA-SFMBT2
be
highly
expressed
ER
cancer
cells
comparison
−
found
that
high
levels
were
related
larger
tumor
size
poor
prognosis
In
vitro
vivo
experiments
confirmed
level
was
positively
correlated
protein
level,
implying
a
regulatory
role
signaling.
Moreover,
biogenesis
could
facilitated
via
RNA-binding
quaking
(QKI),
biologically
elevated
expression
promoted
cell
growth
tamoxifen
Mechanistically,
exhibits
specific
tertiary
structure
endows
it
binding
affinity
allows
interact
AF2
DBD
domains
ERα,
enforcing
recruitment
RNF181
AF1
domain
ERα.
Furthermore,
circRNA-SFMBT2/RNF181
axis
differentially
regulated
K48-linked
K63-linked
ubiquitination
enhance
stability,
resulting
increased
target
genes
progression.
summary,
an
important
regulator
signaling,
antagonizing
may
constitute
potential
therapeutic
strategy
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3101 - 3101
Published: March 27, 2025
Breast
cancer
(BC)
is
a
multifactorial
condition
and
it
primarily
expresses
the
estrogen
receptor
α
(ERα)
that
encoded
by
gene
1
(ESR1),
which
modulates
signaling.
ESR1,
facilitating
overproduction,
plays
an
indispensable
role
in
progression
survival
of
majority
BCs.
To
obtain
molecular
insights
into
these
phenomena,
we
analyzed
The
Cancer
Genome
Atlas
(TCGA)
breast
invasive
carcinoma
(BRCA)
RNA-Seq
datasets
for
expression
ESR1
its
correlation
to
microRNAs
(miRNAs)
long
non-coding
RNAs
(lncRNAs),
along
with
methylation
patterns.
Regulation
was
also
assessed
total
43
cancerous
non-cancerous
cell
lines.
Analyses
both
TCGA
BRCA
line
data
revealed
specific
lncRNAs,
i.e.,
MEG3,
BIK,
MLL,
FAS
are
negatively
correlated
PARP1
demonstrates
positive
association.
Additionally,
miR-30a
miR-145
showed
negative
correlations
expression.
Of
54
loci
analyzed,
them
exhibited
expression,
highlighting
potentially
modifiable
regulatory
mechanism.
These
findings
underscore
complex
events
influencing
interaction
diverse
signaling
pathways,
demonstrating
novel
pathogenesis
potential
therapeutics.
Cancer Biology & Therapy,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Sept. 11, 2024
Prostate
cancer
(PCa)
is
among
the
three
main
types
of
cancer.
Although
prostate-specific
antigen
(PSA)
routinely
tested,
it
has
disadvantages,
such
as
poor
prognostic
ability.
Therefore,
finding
more
PCa
markers
and
therapeutic
targets
remains
a
subject
study.
CircRNAs
have
been
found
to
regulatory
roles
in
various
diseases,
diabetes,
Central
Nervous
System
(CNS)
neuropathy,
etc.
where
their
application
even
valuable.
this
paper
aims
search
for
differentially
expressed
circRNAs
find
downstream
targeting
pathways
related
autophagy.
Frontiers in Molecular Biosciences,
Journal Year:
2023,
Volume and Issue:
10
Published: April 28, 2023
Introduction:
Circular
RNAs
(circRNAs)
regulatory
network
is
important
in
human
cancer.
We,
therefore,
mapped
the
networks
driven
by
circRNA
luminal-subtype
breast
Methods:
Breast
cancer-related
microarray
datasets
from
GEO
database
were
analyzed
for
differentially
expressed
circRNAs,
miRNAs,
and
mRNAs.
The
potential
downstream
collected
using
RNA
Interactome
or
Targetscan
database.
Protein-protein
interaction
(PPI)
analysis
was
performed
filtered
genes
to
identify
hub
genes.
functions
annotated
Gene
Ontology
(GO)
Kyoto
Encyclopedia
of
Genes
Genomes
(KEGG)
enrichment
analysis.
CircRNA-miRNA-mRNA
Cytoscape
software.
Hsa_circ_0086735-miR-1296-5p-STAT1
axis
used
verification.
expression
levels
hsa_circ_0086735,
miR-1296-5p,
STAT1
mRNA
confirmed
qRT-PCR
tissues
cell
lines.
interactions
among
them
verified
Luciferase
reporter
assay
pull-down
assay.
Cell
proliferation
apoptosis
assayed.
Overall
distant
metastasis-free
survival
analyzed.
Results:
A
total
70
finally
targeted
enriched
multi-process
multi-pathway.
Networks
containing
96
circRNA-miRNA-mRNA
axes
constructed.
Hsa_circ_0086735
upregulated
luminal
cancer,
while
miR-1296-5p
downregulated.
promotes
cancer
progression
contributes
tamoxifen
resistance.
High
hsa_circ_0086735
associated
with
poor
overall
survival.
Discussion:
This
study
identified
hsa_circ_0086735-miR-1296-5p-STAT1
as
an
aiding
determine
therapeutic
targets.
