Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
24, P. 100920 - 100920
Published: Dec. 21, 2023
Bone
defects
have
become
a
major
cause
of
disability
and
death.
To
overcome
the
limitations
natural
bone
implants,
including
donor
shortages
immune
rejection
risks,
tissue
engineering
(BTE)
scaffolds
emerged
as
promising
therapy
for
defects.
Despite
possessing
good
biocompatibility,
these
metal,
ceramic
polymer-based
are
still
challenged
by
harsh
conditions
in
defect
sites.
ROS
accumulation,
bacterial
infection,
excessive
inflammation,
compromised
blood
supply
deficiency
tumor
recurrence
negatively
impact
cells
(BTCs)
hinder
osteointegration
BTE
scaffolds.
Phenolic
compounds,
derived
from
plants
fruits,
gained
growing
application
treating
inflammatory,
infectious
aging-related
diseases
due
to
their
antioxidant
ability
conferred
phenolic
hydroxyl
groups.
The
prevalent
interactions
between
phenols
functional
groups
also
facilitate
utilization
fabricating
Consequently,
increasingly
incorporated
into
boost
therapeutic
efficacy
defect.
This
review
demonstrated
effects
on
BTCs
microenvironment,
summarized
intrinsic
mechanisms,
presented
advances
phenol-modified
analyzed
potential
risks
practical
applications.
Overall,
hold
great
repairing
defects,
offering
novel
patterns
scaffold
construction
advancing
traumatological
medicine.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Aug. 15, 2023
Abstract
Glycolytic
reprogramming
is
one
of
the
most
important
features
cancer
and
plays
an
integral
role
in
progression
cancer.
In
cells,
changes
glucose
metabolism
meet
needs
self-proliferation,
angiogenesis
lymphangiogenesis,
metastasis,
also
affect
immune
escape,
prognosis
evaluation
therapeutic
effect
The
n6-methyladenosine
(m6A)
modification
RNA
widespread
eukaryotic
cells.
Dynamic
reversible
m6A
modifications
are
widely
involved
regulation
stem
cell
renewal
differentiation,
tumor
therapy
resistance,
microenvironment,
metabolism.
Lately,
more
evidences
show
that
can
glycolysis
process
tumors
a
variety
ways
to
regulate
biological
behavior
tumors.
this
review,
we
discussed
genesis
development,
elaborated
detail
profound
impact
on
different
by
regulating
glycolysis.
We
believe
modified
has
great
significance
potential
for
treatment.
Journal of Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
66(13), P. 8464 - 8483
Published: June 28, 2023
Hexokinase
2
(HK2)
is
the
principal
rate-limiting
enzyme
in
aerobic
glycolysis
pathway
and
determines
quantity
of
glucose
entering
glycolysis.
However,
current
HK2
inhibitors
have
poor
activity,
so
we
used
proteolysis-targeting
chimera
(PROTAC)
technology
to
design
synthesize
novel
degraders.
Among
them,
C-02
has
best
activity
degrade
protein
inhibit
breast
cancer
cells.
It
demonstrated
that
could
block
glycolysis,
cause
mitochondrial
damage,
then
induce
GSDME-dependent
pyroptosis.
Furthermore,
pyroptosis
induces
cell
immunogenic
death
(ICD)
activates
antitumor
immunity,
thus
improving
immunotherapy
vitro
vivo.
These
findings
show
degradation
can
effectively
metabolism
cells,
thereby
inhibiting
their
malignant
proliferation
reversing
immunosuppressive
microenvironment.
Free Radical Biology and Medicine,
Journal Year:
2023,
Volume and Issue:
208, P. 134 - 152
Published: Aug. 4, 2023
Hepatocellular
carcinoma
(HCC)
is
the
sixth
most
prevalent
cancer
and
fourth
leading
cause
of
cancer-related
death
worldwide.
Advanced
or
metastatic
HCC
currently
managed
using
systemic
drug
therapy
with
unsatisfactory
patient
survival.
Cold
atmospheric
plasma
has
emerged
as
a
promising,
physicochemical,
broad-spectrum
oncotherapy.
In
this
preclinical
study,
we
investigated
anti-neoplastic
functions
mechanism
piezoelectric
direct
discharge
technology-based
CAP,
Piezo-CAP,
on
in
vitro
vivo.
Various
cells
lines,
such
SMMC7721,
HepG2
LM3,
were
used
model
for
phenotypic
mechanistic
studies.
Specifically,
cell
counting
Kit-8
colony
formation
assay,
flow
cytometry,
Transwell
Western
blot,
reactive
oxygen
species
(ROS)
glutathione
to
oxidized
ratio
(GSH/GSSG)
assay
demonstrate
plasma-induced
changes
proliferation,
cycle
progression,
migration
invasion,
epithelial-to-mesenchymal
transition,
intracellular
ROS,
antioxidant
capacity,
respectively.
addition,
Acridine
orange
ethidium
bromide
(AO/EB)
staining
transmission
electron
microscopy
performed
cellular
subcellular
assessment
apoptosis.
The
Ad-mCherry-RFP-LC3B
fluorescent
double-labeled
lentiviral
system
was
detect
autophagic
flux.
On
other
hand,
RNA-sequencing,
quantitative
real-time
PCR,
blot
metabolic
molecular
disruption
tumor
glycolysis
oncogenic
vivo
experiments
human
cell-line-derived
xenograft
immunohistochemistry
(IHC)
utilized
investigate
mechanism.
Piezo-CAP
exerted
through
inhibiting
promote
apoptosis
autophagy.
Treatment
could
suppress
proliferation
induce
autophagy
simultaneously
disrupts
survival
pathways
redox
deregulation,
glycolytic
pathway,
PI3K/AKT/mTOR/HIF1α
pathway
signaling.
Moreover,
upon
translation
these
results
into
tissue
level,
significantly
suppressed
situ
growth.
These
findings
collectively
suggest
that
Piezo-CAP-induced
though
multitargeted
blockade
major
deregulated
balance,
glycolysis,
PI3K/AKT/mTOR/HIF-1α
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9463 - 9463
Published: Aug. 30, 2024
Colorectal
cancer
(CRC)
represents
a
significant
global
health
burden,
with
high
incidence
and
mortality
rates
worldwide.
Recent
progress
in
research
highlights
the
distinct
clinical
molecular
characteristics
of
colon
versus
rectal
cancers,
underscoring
tumor
location's
importance
treatment
approaches.
This
article
provides
comprehensive
review
our
current
understanding
CRC
epidemiology,
risk
factors,
pathogenesis,
management
strategies.
We
also
present
intricate
cellular
architecture
colonic
crypts
their
roles
intestinal
homeostasis.
carcinogenesis
multistep
processes
are
described,
covering
conventional
adenoma-carcinoma
sequence,
alternative
serrated
pathways,
influential
Vogelstein
model,
which
proposes
sequential
