Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 9, 2023

Abstract The use of nanotechnology has the potential to revolutionize detection and treatment cancer. Developments in protein engineering materials science have led emergence new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers medicinal purposes been approved human trials, only a few authorized clinical cells. In this review, we analyze some formulations discuss challenges translating findings from lab clinic. This study highlights various compounds that can be used selective tumor inherent difficulties therapy. Nanotechnology provides promising platform improving future, but further research is needed overcome current limitations translation. Graphical

Language: Английский

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Nanomedomics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

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A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(19)

Published: Jan. 18, 2024

Abstract Hydrogen sulfide (H 2 S) is being progressively integrated as an emerging inhibitor of the electron transport chain in energy interference‐based tumor therapy. However, metabolic reprogramming cancer cells causes both oxidative phosphorylation (OXPHOS) and glycolysis to occur simultaneously, which contributes ineffective therapeutic effect blocking a single pathway. To achieve complete suppression production, inorganic H S donor ZnS@ZIF‐8@CaP nanoparticle (ZSZC NP) carrying Ca Zn constructed for achieving simultaneous interference OXPHOS glycolysis. The core–shell ZSZC nanoparticles can break down microenvironment. This leads sustained release calcium overload disrupt normal functioning mitochondria by inhibiting expression cytochrome c causing damage mitochondrial membrane potential. Meanwhile, presence 2+ hinders typical process impeding lactate dehydrogenase glyceraldehyde‐3‐phosphate dehydrogenase. synchronous hampers supply cells. Additionally, expedite necrosis vivo inducing cellular acidification calcification. Therefore, this energy‐blocking strategy will completely deplete reserves provide new insights exploring bioenergetic inhibition treatment approach.

Language: Английский

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Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 8, 2024

Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze production of reactive oxygen species (ROS) without requiring external stimuli catalytic substrates confirmed to be (O2) hydrogen peroxide (H2O2) through computational simulation experiments. Considering short O2 H2O2 at site, we utilize calcium (CaO2) supply for VPQDs construct nanoparticles together with them, named VPCaNPs. VPCaNPs induce oxidative stress cells, particularly characterized by a significant increase hydroxyl radicals superoxide radicals, which cause substantial damage structure function ultimately leading cell apoptosis. Intriguingly, provided CaO2 degrade slowly, degradation product, phosphate, as well CaO2-generated ions, promote calcification. Antitumor immune activation less metastasis also observed administrated animals. In conclusion, our study unveils anti-tumor activity catalysts generating cytotoxic ROS products calcification, providing promising strategy treating tumors.

Language: Английский

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Photoacoustic‐Imaging‐Guided Photothermal Regulation of Calcium Influx for Enhanced Immunogenic Cell Death

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(19)

Published: Jan. 15, 2024

Abstract Immunogenic cell death (ICD) induced by calcium ion (Ca 2+ ) overload has attracted significant attention owing to its ability activate the immune system and generate durable antitumor responses. However, slow release of Ca commonly used nanomodulators provides tumor cells with opportunity efficiently eliminate excess through channels, thus diminishing therapeutic efficacy. Consequently, it is crucial explore strategies for rapid release. To address this issue, a glutathione‐triggered Ca(IO 3 2 @starch‐based nanobomb presented. This not only enables accurate efficient delivery site but also exploits photoacoustic (PA) imaging‐guided photothermal precise control TRPV1 channel activation enhancing influx. Both in vitro vivo results confirm that photothermally regulated influx based on effectively promotes ICD stimulates infiltration tissues, ultimately leading effective inhibition growth metastasis. The developed presents potential strategy enhance overload, addressing challenges associated timely regulation offering prospects improved immunotherapy.

Language: Английский

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A metal-organic framework (MOF) built on surface-modified Cu nanoparticles eliminates tumors via multiple cascading synergistic therapeutic effects

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 662, P. 298 - 312

Published: Feb. 9, 2024

Language: Английский

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Covalent organic frameworks-derived carbon nanospheres based nanoplatform for tumor specific synergistic therapy via oxidative stress amplification and calcium overload

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 661, P. 908 - 922

Published: Feb. 5, 2024

Language: Английский

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Dual‐Release Free Iron and Breakdown of Ferroptosis Defenses to Achieve Ferroptosis Cascade Storms for Potent Antitumor Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Ferroptosis is a newly identified type of regulated cell death characterized by iron‐dependent lipid peroxidation. Among the main ferroptosis‐suppressing systems, dihydroorotate dehydrogenase (DHODH)‐ ubiquinone axis closely related to mitochondria and energy metabolism, implying that protects cells from oxidative stress damage via maintenance redox homeostasis. However, ferroptosis initiation requires suitable environment breakthrough in homeostatic limitations systems. Hence, nanoparticles are rationally engineered achieve efficient induction releasing dual‐release free iron disrupting Atovaquone (ATO)‐loaded hollow mesoporous etching zeolitic imidazolate framework‐67 double‐coated oxide/calcium phosphate (Fe 3 O 4 /CaP) conjugated with polyethylene glycol. The external Fe /CaP structure enhances efficiency multiple reactive oxygen species (ROS) generation promoting stress. Still, it achieves increase content unstable pools for igniting ROS storm peroxidation spark. release ATO not only affects metabolism mitochondrial respiratory chain binding complex III but also downregulates DHODH restrict ubiquinol system disrupt Therefore, design this composite nanomedicine provides an approach inducing theoretical basis clinical anti‐tumor trials.

Language: Английский

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Selective arrangement of three types of calcium–terbium tetranuclear cores by a thiacalixarene ligand using thermodynamic and kinetic strategies

RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3849 - 3857

Published: Jan. 1, 2025

Thiacalix[4]arene- p -tetrasulfonate (TCAS) can selectively form three types of heterotetranuclear Ca x Tb 4− TCAS 2 complexes ( = 1−3) with energy transfer luminescence.

Language: Английский

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CaCO₃ nanoplatform for cancer treatment: drug delivery and combination therapy

Nanoscale, Journal Year: 2024, Volume and Issue: 16(14), P. 6876 - 6899

Published: Jan. 1, 2024

CaCO 3 nanoparticles as nanocarriers for drug, protein, gene, and co-delivery are discussed. Furthermore, their combinations with other therapies, including photodynamic therapy, sonodynamic immunotherapy, imaging, reviewed.

Language: Английский

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