The stress of losing sleep: Sex-specific neurobiological outcomes

Neurobiology of Stress, Journal Year: 2023, Volume and Issue: 24, P. 100543 - 100543

Published: May 1, 2023

Sleep is a vital and evolutionarily conserved process, critical to daily functioning homeostatic balance. Losing sleep inherently stressful leads numerous detrimental physiological outcomes. Despite disturbances affecting everyone, women female rodents are often excluded or underrepresented in clinical pre-clinical studies. Advancing our understanding of the role biological sex responses loss stands greatly improve ability understand treat health consequences insufficient sleep. As such, this review discusses differences response deprivation, with focus on sympathetic nervous system stress activation hypothalamic-pituitary-adrenal (HPA) axis. We several stress-related loss, including inflammation, learning memory deficits, mood related changes. Focusing women's health, we discuss effects deprivation during peripartum period. In closing, present neurobiological mechanisms, contribution hormones, orexins, circadian timing systems, astrocytic neuromodulation, that may underlie potential responses.

Language: Английский

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Mechanism of action of the Banxia–Xiakucao herb pair in sleep deprivation: New comprehensive evidence from network pharmacology, transcriptomics and molecular biology experiments

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118534 - 118534

Published: Nov. 1, 2024

Language: Английский

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Recent Progress in Long-Term Sleep Monitoring Technology

Biosensors, Journal Year: 2023, Volume and Issue: 13(3), P. 395 - 395

Published: March 17, 2023

Sleep is an essential physiological activity, accounting for about one-third of our lives, which significantly impacts memory, mood, health, and children’s growth. Especially after the COVID-19 epidemic, sleep health issues have attracted more attention. In recent years, with development wearable electronic devices, there been studies, products, or solutions related to monitoring. Many mature technologies, such as polysomnography, applied clinical practice. However, it urgent develop non-contacting devices suitable household continuous This paper first introduces basic knowledge significance Then, according types signals monitored, this describes research progress bioelectrical signals, biomechanical biochemical used not ideal monitor quality whole night based on only one signal. Therefore, reviews multi-signal monitoring systematic schemes. Finally, a conclusion discussion are presented propose potential future directions prospects

Language: Английский

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Circadian Rhythms in Cardiovascular Function: Implications for Cardiac Diseases and Therapeutic Opportunities

Medical Science Monitor, Journal Year: 2023, Volume and Issue: 29

Published: Oct. 2, 2023

Circadian rhythms are internal 24-h intrinsic oscillations that present in essentially all mammalian cells and can influence numerous biological processes.Cardiac function is known to exhibit a circadian rhythm strongly affected by the day/night cycle.Many cardiovascular variables, including heart rate, rate variability (HRV), electrocardiogram (ECG) waveforms, endothelial cell function, blood pressure, demonstrate robust rhythms.Many experiential clinical studies have highlighted disruptions ultimately lead maladaptive cardiac function.Factors disrupt rhythm, shift work, global travel, sleep disorders, may consequently enhance risk of diseases.Some diseases appear occur at particular times day or night; therefore, targeting disease improve outcome.The objective this review unravel relationship between health.By understanding intricate interplay, we aim reveal potential risks disruption discuss emerging therapeutic strategies, specifically those rhythms.In review, explore important role physiology highlight they play dysfunction such as ventricular hypertrophy, arrhythmia, diabetes, myocardial infarction.Finally, translational treatments aimed rhythms.These offer an innovative approach enhancing existing approaches for managing treating heart-related conditions, while also opening new avenues development.

Language: Английский

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Berberine Ameliorates Metabolic-Associated Fatty Liver Disease Mediated Metabolism Disorder and Redox Homeostasis by Upregulating Clock Genes: Clock and Bmal1 Expressions

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1874 - 1874

Published: Feb. 16, 2023

Metabolic-associated fatty liver disease (MAFLD) is one of the most common chronic diseases, which in turn triggers mild inflammation, metabolic dysfunction, fibrosis, and even cancer. Accumulating evidence has suggested that Berberine (BBR) could significantly improve MAFLD progression. Clock Bmal1 as heterodimer proteins highly participated development MAFLD, but whether BBR targets remains poorly understood. The result protein levels were decreased mice, was negatively correlated with elevated reactive oxygen species (ROS) accumulation, H2O2 level, insulin resistance. mRNA also glucosamine-induced HepG2 cells, are related to glucose uptake, ROS level. More importantly, siRNA mimic effect glucosamine cells. Interestingly, rescue metabolism disorder redox homeostasis through enhancing expression vivo vitro. Therefore, might be an effective natural compound for alleviating homeostasis, disorder, pathological changes by activating expression.

Language: Английский

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Altered circadian pattern of activity in a chronic activity-based anorexia nervosa-like female mouse model deficient for GHSR

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: 177, P. 107453 - 107453

Published: April 4, 2025

Language: Английский

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The effect of chronotype characteristics on cardiovascular health behaviors in school-age children: A cross-sectional study

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: April 21, 2025

This study aimed to investigate the effect of chronotype characteristics on cardiovascular health behaviors in school-age children. descriptive, correlational, and cross-sectional involved 424 children aged 10-12. Participants completed Morningness-Eveningness Scale for Children (MESC) Cardiovascular Health Behavior (CHBSC). The results were analyzed using descriptive statistics multivariate regression analysis, adhering ethical principles throughout study. mean MESC CHBSC scores 28.37 ± 5.20 57.04 11.34, respectively. 53.8% exhibited moderate behaviors, while 79% had a chronotype. A negative correlation was observed between (r = -0.39, p < 0.01), with explaining 16% variance behaviors. influenced its subscales nutrition, exercise, sedentary lifestyle, self-love, stress subscales. Most display intermediate an evening demonstrated lower levels Chronotype most impact lifestyle aspect Furthermore, plays significant role key factors influencing

Language: Английский

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Sleep Loss Causes Dysfunction in Murine Extraorbital Lacrimal Glands

Investigative Ophthalmology & Visual Science, Journal Year: 2022, Volume and Issue: 63(6), P. 19 - 19

Published: June 22, 2022

Sleep loss markedly affects the structure and function of lacrimal gland may cause ocular surface disease as a common public health problem. This study aims to investigate circadian disturbance caused by sleep leading dysfunction extraorbital glands (ELGs).A mouse deprivation (SD) model for studies was built in C57BL/6J male mice. After four weeks, ELGs were collected at three-hour intervals during 24-hour period. The Jonckheere-Terpstra-Kendall algorithm used determine composition, phase, rhythmicity transcriptomic profiles ELGs. Furthermore, we compared non-sleep-deprived SD-treated ELG (i) reactive oxygen species (ROS) fluorescein staining, (ii) DNA damage immunostaining γ-H2Ax, (iii) migration immune cells CD4, CD8, γδ-TCR, CD64, CX3CR1. Finally, also evaluated locomotor activity core body temperature rhythm mice mass, cell size, tear secretion ELGs.SD dramatically altered composition phase-associated functional enrichment transcriptome, trafficking, metabolism, differentiation, neural secretory activities Additionally, SD ROS accumulation consequent ELGs, irreversible.SD damages structure, function, diurnal oscillations These results highlight comprehensive characterization insufficient sleep-affected transcriptome that provide new therapeutic approach counteract effects on function.

Language: Английский

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Daily rhythms, light exposure and social jetlag correlate with demographic characteristics and health in a nationally representative survey

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 29, 2023

Abstract The timing of daily activity in humans have been associated with various demographic and health-related factors, but the possibly complex patterns confounding interaction between these has not systematically explored. We use data from Hungarostudy 2021, a nationally representative survey 7000 Hungarian adults to assess relationship self-reported chronotype, social jetlag (using Munich Chronotype Questionnaire), variables health variables, including ethnic minority membership. Supporting validity self-reports, participants later chronotypes reported lowest daytime sleepiness at clock time. found that older age, female sex, more eastward southward geographical position, residence smaller settlement, less education income, religiousness cohabiting small children were an earlier chronotype. Younger higher increased jetlag. Of 48 surveyed, both chronotype mostly accounted for by socioeconomic effects, we identified alcohol consumption, smoking, physical as predictors while number disorders either positively or negatively Our findings large, sample indicate biological factors influence risk results, however, do support causal light exposure mental health.

Language: Английский

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Sleep Disturbance in Rodent Models and Its Sex-Specific Implications

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105810 - 105810

Published: July 14, 2024

Language: Английский

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