The effect of chronotype characteristics on cardiovascular health behaviors in school-age children: A cross-sectional study

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: April 21, 2025

This study aimed to investigate the effect of chronotype characteristics on cardiovascular health behaviors in school-age children. descriptive, correlational, and cross-sectional involved 424 children aged 10-12. Participants completed Morningness-Eveningness Scale for Children (MESC) Cardiovascular Health Behavior (CHBSC). The results were analyzed using descriptive statistics multivariate regression analysis, adhering ethical principles throughout study. mean MESC CHBSC scores 28.37 ± 5.20 57.04 11.34, respectively. 53.8% exhibited moderate behaviors, while 79% had a chronotype. A negative correlation was observed between (r = -0.39, p < 0.01), with explaining 16% variance behaviors. influenced its subscales nutrition, exercise, sedentary lifestyle, self-love, stress subscales. Most display intermediate an evening demonstrated lower levels Chronotype most impact lifestyle aspect Furthermore, plays significant role key factors influencing

Language: Английский

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Synchronizing our clocks as we age: the influence of the brain-gut-immune axis on the sleep-wake cycle across the lifespan

SLEEP, Journal Year: 2021, Volume and Issue: 45(3)

Published: Nov. 10, 2021

Abstract The microbes that colonize the small and large intestines, known as gut microbiome, play an integral role in optimal brain development function. microbiome is a vital component of bidirectional communication pathway between brain, immune system, gut, also brain-gut-immune axis. To date, there has been minimal investigation into implications improper axis on sleep-wake cycle, particularly during sensitive periods physical neurological development, such childhood, adolescence, senescence. Therefore, this review will explore current literature surrounding overlapping developmental system from birth through to senescence, while highlighting how affects maturation organization cycle. We examine dysfunction either or cycle negatively relationship subsequently overall health functionality complex system. Additionally, integrates therapeutic studies demonstrate when dietary manipulations, supplementation with probiotics prebiotics, can modulate enhance optimize our

Language: Английский

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Chronic corticosterone disrupts the circadian rhythm of CRH expression and m6A RNA methylation in the chicken hypothalamus

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2022, Volume and Issue: 13(1)

Published: March 8, 2022

Corticotropin-releasing hormone (CRH), the major secretagogue of hypothalamic-pituitary-adrenal (HPA) axis, is intricately intertwined with clock genes to regulate circadian rhythm various body functions. N6-methyladenosine (m6A) RNA methylation involved in regulation rhythm, yet it remains unknown whether CRH expression and m6A modification oscillate chicken hypothalamus how rhythms change under chronic stress.Chronic exposure corticosterone (CORT) eliminated diurnal patterns plasma CORT melatonin levels chicken. The hippocampus, pituitary are all disturbed different extent CORT-treated chickens. most striking changes occur which fluctuation mRNA flattened, together other feeding-related neuropeptides. Interestingly, hypothalamic level oscillates an opposite pattern mRNA, lowest after midnight (ZT18) corresponding peak before dawn (ZT22). diminished significantly increased at night. Further site-specific analysis on 3'UTR indicates that higher coincides lower night (ZT18 ZT22).Our results indicate stress disrupts hypothalamus, leading dysfunction HPA axis both basal conditions.

Language: Английский

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Sleep Disturbance in Rodent Models and Its Sex-Specific Implications

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105810 - 105810

Published: July 14, 2024

Language: Английский

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Pterostilbene targets the molecular oscillator RORγ to restore circadian rhythm oscillation and protect against sleep restriction induced metabolic disorders

Phytomedicine, Journal Year: 2024, Volume and Issue: 125, P. 155327 - 155327

Published: Jan. 2, 2024

Language: Английский

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Melatonin and Vascular Function

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 747 - 747

Published: June 20, 2024

The indolamine hormone melatonin, also known as N-acetyl-5-methoxytrypamine, is frequently associated with circadian rhythm regulation. Light can suppress melatonin secretion, and photoperiod regulates levels by promoting its production secretion at night in response to darkness. This becoming more understood for functions an immune-modulatory, anti-inflammatory, antioxidant hormone. Melatonin may have a major effect on several diabetes-related disturbances, such hormonal imbalances, oxidative stress, sleep mood disorders, according recent research. has raised interest investigating the possible therapeutic advantages of treatment diabetic complications. In addition, studies described that been linked development diabetes, cancer, Alzheimer’s disease, immune system heart diseases. this review, we will highlight some regarding vascular biology.

Language: Английский

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Many faces of sleep regulation: beyond the time of day and prior wake time

FEBS Journal, Journal Year: 2021, Volume and Issue: 290(4), P. 931 - 950

Published: Dec. 15, 2021

The two-process model of sleep regulation posits two main processes regulating sleep: the circadian process controlled by clock and homeostatic that depends on history wakefulness. has provided a dominant conceptual framework for research since its publication ~ 40 years ago. time day prior wake are primary factors affecting processes, respectively. However, it is critical to consider other influencing sleep. Since incompatible with behaviors, affected need essential behaviors such as eating, foraging, mating, caring offspring, avoiding predators. Sleep also sensory inputs, sickness, increased memory consolidation after learning, factors. Here, we review multiple discuss recent insights into mechanisms balancing competing needs.

Language: Английский

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The relationship between chronotype video game addiction and sleep quality in school-age children: A structural equation modeling approach

Chronobiology International, Journal Year: 2024, Volume and Issue: 41(11), P. 1422 - 1429

Published: Oct. 24, 2024

This study aimed to investigate the relationship between chronotype, video game addiction, and sleep quality in school-age children using structural equation modeling. It was performed modeling, with 545 secondary school students northern Turkey meeting inclusion criteria. Data were collected through face-to-face interviews utilizing Personal Information Form, Morningness Eveningness Scale for Children (MESC), Video Game Addiction (VASC), Sleep Quality Scale. The findings revealed that average addiction score of 55.22, which associated poor efficiency. Additionally, chronotype found mediate both (β = 0.024; p < 0.001) efficiency −0.068; 0.001). model be close acceptable levels variables according fit indices.

Language: Английский

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Top-down and bottom-up alterations of connectivity patterns of the suprachiasmatic nucleus in chronic insomnia disorder

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2023, Volume and Issue: 274(2), P. 245 - 254

Published: Feb. 22, 2023

Language: Английский

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A clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 11, 2023

Abstract Circadian clocks generate rhythms of arousal, but the underlying molecular and cellular mechanisms remain unclear. In Drosophila , clock output molecule WIDE AWAKE (WAKE) labels rhythmic neural networks cyclically regulates sleep arousal. Here, we show, in a male mouse model, that mWAKE/ANKFN1 subpopulation dorsomedial hypothalamus (DMH) neurons involved arousal acts DMH to reduce at night. vivo Ca 2+ imaging reveals elevated mWAKE activity during wakefulness rapid eye movement (REM) sleep, while patch-clamp recordings show fire more frequently Chemogenetic manipulations demonstrate are necessary sufficient for Single-cell profiling coupled with optogenetic activation experiments suggest GABAergic promote Surprisingly, our data as clock-dependent brake on night, when mice normally active. levels peak night under control, loss leads hyperarousal greater neuronal excitability specifically These results does not solely an animal’s active period, instead uses opposing processes produce appropriate time-dependent manner.

Language: Английский

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