Heliyon,
Journal Year:
2024,
Volume and Issue:
10(5), P. e27036 - e27036
Published: Feb. 24, 2024
The
exacerbated
global
water
scarcity
and
stricter
directives
are
leading
to
an
increment
in
the
recycled
use,
requiring
development
of
new
cost-effective
advanced
treatments
provide
safe
population.
In
this
sense,
peracetic
acid
(PAA,
CH
Processes,
Journal Year:
2023,
Volume and Issue:
11(9), P. 2771 - 2771
Published: Sept. 16, 2023
In
this
review,
we
have
focused
mainly
on
the
study
of
their
antioxidant
and
pro-oxidant
capacity,
analysis
oxidation
catechol
group
to
o-quinone.
The
redox
balance
established
between
different
oxidase
reductase
enzymes
generates
reducing
species,
H+
e−,
allows
polyphenolic
groups
quinones
be
reversible.
This
continuous
these
nucleophilic
electrophilic
substances
activation
NRF2/ARE
axis,
which
regulates
cellular
responses
against
oxidative
stress,
as
well
cell
proliferation.
Understanding
ambivalent
character
polyphenols,
can
act
simultaneously
antioxidants
pro-oxidants,
will
allow
design
specific
therapies
that
serve
science
medicine
in
tasks.
Advances in Redox Research,
Journal Year:
2024,
Volume and Issue:
11, P. 100099 - 100099
Published: April 9, 2024
Cellular
metabolic
activities
are
controlled
by
pathways
catalyzed
enzymes,
closely
regulated
signal
transduction
through
induction
or
inhibition
processes.
Metabolic
disorders
and
cellular
dysregulation
often
linked
to
redox-dependent
signaling
in
a
complex
relationship.
Glutathione
(GSH)
polyphenols
which
known
regulators
of
redox
homeostasis
have
been
studied
immensely.
However,
no
study
has
considered
their
potential
interactions
synergies
as
novel
mechanisms
control
disorders.
GSH
does
not
only
act
an
antioxidant,
but
ligand
that
binds
inactivate
enzymes
toxins.
Also,
depending
on
environment,
structure,
pH,
concentration
availability
transition
metals
high
charge
density,
may
possess
either
anti-oxidant
pro-oxidant
properties.
Owing
remarkable
influence
individual
compounds,
this
the
between
disease
management.
Generally,
both
reduce
oxidative
stress
normal
cells
under
exacerbating
conditions
low
GSH/GSSG
ratio,
induce
apoptotic
abnormal
cells.
Investigating
effects
polyphenol
concentrations,
metals,
caloric
restriction
structure
apoptosis
proliferation
cancer
future
be
basis
for
synergistic
exploitation
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1379 - 1379
Published: Feb. 6, 2025
Atherosclerosis,
a
chronic
inflammatory
disease
characterized
by
the
accumulation
of
lipids
and
immune
cells
within
arterial
walls,
remains
leading
cause
cardiovascular
morbidity
mortality
worldwide.
Oxidative
stress
inflammation
are
central
to
its
pathogenesis,
driving
endothelial
dysfunction,
foam
cell
formation,
plaque
instability.
Emerging
evidence
highlights
potential
bioactive
compounds
with
antioxidant
anti-inflammatory
properties
mitigate
these
processes
promote
vascular
health.
This
review
explores
mechanisms
through
which
compounds-such
as
polyphenols,
carotenoids,
flavonoids,
omega-3
fatty
acids,
coenzyme
Q10,
other
natural
compounds-modulate
oxidative
in
atherosclerosis.
It
examines
their
effects
on
key
molecular
pathways,
including
inhibition
reactive
oxygen
species
(ROS)
production,
suppression
nuclear
factor-κB
(NF-κB),
modulation
cytokines.
By
integrating
current
knowledge,
this
underscores
therapeutic
dietary
supplemental
complementary
strategies
for
managing
atherosclerosis,
paving
way
future
research
clinical
applications.