The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC)

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115170 - 115170

Published: July 21, 2023

Breast cancer is a leadingcause of cancer-related deaths in women globally, with triple-negative breast (TNBC) being an aggressive subtype that lacks targeted therapies and associated poor prognosis. Polyphenols, naturally occurring compounds plants, have been investigated as potential therapeutic strategy for TNBC. This review provides overview the anticancer effects polyphenols TNBC their mechanisms action. Several polyphenols, including resveratrol, quercetin, kaempferol, genistein, epigallocatechin-3-gallate, apigenin, fisetin, hesperetin luteolin, shown to inhibit cell proliferation, induce cycle arrest, promote apoptosis, suppress migration/invasion preclinical models. The molecular underlying involve modulation several signalling pathways, such PI3K/Akt, MAPK, STATT, NF-κB pathways. Polyphenols also exhibit synergistic chemotherapy drugs, making them promising candidates combination therapy. highlights clinical trials investigating use individually or therapy, against cancer. deepens under-standing mechanism action respective valuable insights into TNBC, lays groundwork future research this area.

Language: Английский

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Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health

Biomolecules, Journal Year: 2022, Volume and Issue: 12(5), P. 626 - 626

Published: April 23, 2022

Flavonoids are natural phytochemicals that have therapeutic effects and act in the prevention of several pathologies. These can be found seeds, grains, tea, coffee, wine, chocolate, cocoa, vegetables and, mainly, citrus fruits. Neohesperidin, hesperidin hesperetin flavonoids from flavanones subclass anti-inflammatory antioxidant potential. form neohesperidin dihydrochalcone (NHDC), also has dietary properties as a sweetener. In general, these been investigated strategy to control bone diseases, such osteoporosis osteoarthritis. this literature review, we compiled studies neohesperidin, its aglycone, hesperetin, on health. vitro showed exerted an antiosteoclastic anti- inflammatory effects, inhibiting expression osteoclastic markers reducing levels reactive oxygen species, proinflammatory cytokines matrix metalloproteinase levels. Similarly, favored osteogenic potential preosteoblastic cells induced overexpression markers. vivo, regeneration defects minimized inflammation arthritis- periodontitis-induced models. Additionally, they significant anticatabolic effect ovariectomy models, trabecular loss increasing mineral density. Although research should advance clinical field, may for controlling progression metabolic, autoimmune or diseases.

Language: Английский

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Co-Delivery of Hesperetin and Cisplatin via Hyaluronic Acid-Modified Liposome for Targeted Inhibition of Aggression and Metastasis of Triple-Negative Breast Cancer

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(29), P. 34360 - 34377

Published: July 11, 2023

Having no specific therapy for triple-negative breast cancer (TNBC), this subtype has the lowest survival rate and highest metastatic risk of since tumor inflammatory microenvironment mainly accounts heterogeneity-induced insensitivity to chemotherapy epithelial-mesenchymal transition (EMT). This study reports hyaluronic acid (HA)-modified liposomes loaded with cisplatin (CDDP) hesperetin (Hes) (CDDP-HA-Lip/Hes) active targeting relieve systematic toxicity effective anti-tumor/anti-metastasis ability TNBC. Our results revealed that HA modification promoted cellular uptake synthesized CDDP-HA-Lip/Hes nanoparticles in MDA-MB-231 cells accumulation sites vivo, indicating deeper penetration. Importantly, inhibited PI3K/Akt/mTOR pathway alleviate inflammation a crosstalk suppress process EMT, increasing chemosensitivity inhibiting metastasis. Meanwhile, could significantly inhibit aggression metastasis TNBC less side effects on normal tissues. Overall, provides tumor-targeting drug delivery system great potential treating its lung robustly.

Language: Английский

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Progress of research on the role of active ingredients of Citri Reticulatae Pericarpium in liver injury

Phytomedicine, Journal Year: 2023, Volume and Issue: 115, P. 154836 - 154836

Published: April 19, 2023

Language: Английский

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Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3980 - 3980

Published: Aug. 5, 2023

Lung cancer is a heterogeneous group of malignancies with high incidence worldwide. It the most frequently occurring in men and second common women. Due to its frequent diagnosis variable response treatment, lung was reported as top cause cancer-related deaths worldwide 2020. Many aberrant signaling cascades are implicated pathogenesis cancer, including those involved apoptosis (B cell lymphoma protein, Bcl-2-associated X first signal ligand), growth inhibition (tumor suppressor protein or gene serine/threonine kinase 11), promotion (epidermal factor receptor/proto-oncogenes/phosphatidylinositol-3 kinase). Accordingly, these pathways their molecules have become promising targets for chemopreventive chemotherapeutic agents. Recent research provides compelling evidence use plant-based compounds, known collectively phytochemicals, anticancer This review discusses major contributing pathophysiology well currently available treatments prospective drug candidates. The potential naturally bioactive compounds context also discussed, critical analysis mechanistic actions presented by preclinical clinical studies.

Language: Английский

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Isorhamnetin induces cell cycle arrest and apoptosis by triggering DNA damage and regulating the AMPK/mTOR/p70S6K signaling pathway in doxorubicin-resistant breast cancer

Phytomedicine, Journal Year: 2023, Volume and Issue: 114, P. 154780 - 154780

Published: March 21, 2023

Language: Английский

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Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals

Molecules, Journal Year: 2023, Volume and Issue: 28(2), P. 613 - 613

Published: Jan. 6, 2023

Cocrystallization is currently an attractive technique for tailoring the physicochemical properties of active pharmaceutical ingredients (APIs). Flavonoids are a large class natural products with wide range beneficial properties, including anticancer, anti-inflammatory, antiviral and antioxidant which makes them extensively studied. In order to improve flavonoids, such as solubility bioavailability, formation cocrystals may be feasible strategy. This review discusses in detail possible hydrogen bond sites structure APIs bonding networks cocrystal structures, will targeted synthesis flavonoid cocrystals. addition, some successful studies that favorably alter through cocrystallization coformers also highlighted here. addition improving bioavailability flavonoids most cases, their other anti-inflammatory activity photoluminescence properties.

Language: Английский

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A Review on Dietary Flavonoids as Modulators of the Tumor Microenvironment

Molecular Nutrition & Food Research, Journal Year: 2023, Volume and Issue: 67(7)

Published: Jan. 26, 2023

Abstract The tumor microenvironment (TME) is the local environment where malignant cells strive and survive, composed of cancer their surroundings, regulating essential survival, promotion functions. Dietary flavonoids are abundantly present in common vegetables fruits exhibit good anti‐cancer activities, which significantly inhibit tumorigenesis by targeting TME constituents interaction with cells. This review aims to synthesize information concerning modulation dietary flavonoids, as well provide insights into molecular basis its potential anti‐tumor an emphasis on ability control intracellular signaling cascades that regulate processes, involving cell proliferation, invasion migration, continuous angiogenesis, immune inflammation. study will a theoretical for development leading compound therapies from these flavonoids.

Language: Английский

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Flavonoids as promising anticancer therapeutics: Contemporary research, nanoantioxidant potential, and future scope

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(11), P. 5159 - 5192

Published: Sept. 5, 2023

Abstract Flavonoids are natural polyphenolic compounds considered safe, pleiotropic, and readily available molecules. It is widely distributed in various food products such as fruits vegetables beverages green tea, wine, coca‐based products. Many studies have reported the anticancer potential of flavonoids against different types cancers, including solid tumors. The chemopreventive effect attributed to mechanisms, modulation autophagy, induction cell cycle arrest, apoptosis, antioxidant defense. Despite significant activity flavonoids, their clinical translation limited due poor biopharmaceutical attributes (such low aqueous solubility, permeability across biological membranes (intestinal blood‐brain barrier), stability issue systems). A nanoparticulate system an approach that utilized improve performance therapeutic efficacy phytopharmaceuticals. present review discusses promising cancers utilization systems nanoantioxidant further enhance loaded flavonoids. Although, plant‐derived secondary metabolites been recommended for treating cancer, vigilant research warranted prove translational values.

Language: Английский

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Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 382, P. 110642 - 110642

Published: July 23, 2023

Language: Английский

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