Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis,in vitrobiological evaluation, andin silicoADMET analysis with molecular modeling simulations

RSC Advances, Journal Year: 2023, Volume and Issue: 13(14), P. 9281 - 9303

Published: Jan. 1, 2023

Recently, scientists developed a powerful strategy called “one drug-multiple targets” to discover vital and unique therapies fight the most challenging diseases.

Language: Английский

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Short and Long-Term Impact of COVID-19 Infection on Previous Respiratory Diseases

Archivos de Bronconeumología, Journal Year: 2022, Volume and Issue: 58, P. 39 - 50

Published: April 1, 2022

Language: Английский

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Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

European Respiratory Review, Journal Year: 2022, Volume and Issue: 31(164), P. 220028 - 220028

Published: June 14, 2022

COPD is predicted to become the third leading cause of morbidity and mortality worldwide by 2030. Cigarette smoking (active or passive) one its chief causes, with about 20% cigarette smokers developing from smoke (CS)-induced irreversible damage sustained inflammation airway epithelium. Inflammasome activation leads cleavage pro-interleukin (IL)-1β pro-IL-18, along release pro-inflammatory cytokines via gasdermin D N-terminal fragment membrane pores, which further triggers acute phase responses concurrent pyroptosis. There currently intense interest in role nucleotide-binding oligomerisation domain-like receptor family, pyrin domain containing protein-3 inflammasomes chronic inflammatory lung diseases such as their potential for therapeutic targeting. Phytochemicals including polyphenols flavonoids have phyto-medicinal benefits CS-COPD. Here, we review published articles last decade regarding known associations between inflammasome-mediated ameliorations pre-clinical manifestations CS-COPD polyphenol flavonoid treatment, a focus on underlying mechanistic insights. This article will potentially assist development drugs prevention therapy COPD, particularly smokers.

Language: Английский

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Mutational Pattern, Impacts and Potential Preventive Strategies of Omicron SARS-CoV-2 Variant Infection

Infection and Drug Resistance, Journal Year: 2022, Volume and Issue: Volume 15, P. 1871 - 1887

Published: April 1, 2022

Abstract: Since the emergence of COVID 19, authentic SARS-CoV-2 has evolved into a range novel variants that are more global concern. In late November 2021, Omicron (lineage B.1.1.529) variant was identified as new and considered fifth harbors genetic profile is exceedingly unusual, with huge number mutations. Above thirty mutations localized in S protein, while some found other structural non-structural proteins. Half protein RBD, which major target antibodies, showing may affect antibody binding affinity to protein. The been result immune escape, therapeutic or vaccine well increased transmissibility reinfection risk, explaining its rapid international spread sparks alarm even serious than previously reported variants. capability bypass at least multi-faceted responses induced by prior infection vaccination. It shown extensively escape neutralizing antibodies evading cell mediated defense lesser extent. efficacy 19 vaccines against decreased primary vaccination, less efficient preventing infections. However, after receiving booster dose, immunological response significantly improved hold promising results. Despite mild nature disease most vaccinated people, Omicron, risk re-infection, poses yet another public health Therefore, effort should be devoted maintaining existing preventive measures developing vaccination strategies order control fast dissemination Omicron. Keywords: variant, VOC, impact, efficacy,

Language: Английский

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Role of Angiotensin II in Cardiovascular Diseases: Introducing Bisartans as a Novel Therapy for Coronavirus 2019

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 787 - 787

Published: May 2, 2023

Cardiovascular diseases (CVDs) are the main contributors to global morbidity and mortality. Major pathogenic phenotypes of CVDs include development endothelial dysfunction, oxidative stress, hyper-inflammatory responses. These have been found overlap with pathophysiological complications coronavirus disease 2019 (COVID-19). identified as major risk factors for severe fatal COVID-19 states. The renin–angiotensin system (RAS) is an important regulatory in cardiovascular homeostasis. However, its dysregulation observed CVDs, where upregulation angiotensin type 1 receptor (AT1R) signaling via II (AngII) leads AngII-dependent CVDs. Additionally, interaction between spike protein acute respiratory syndrome 2 angiotensin-converting enzyme downregulation latter, resulting RAS. This favors AngII/AT1R toxic pathways, providing a mechanical link pathology COVID-19. Therefore, inhibiting through blockers (ARBs) has indicated promising therapeutic approach treatment Herein, we review role AngII We also provide future direction potential implication novel class ARBs called bisartans, which speculated contain multifunctional targeting towards

Language: Английский

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Role of SARS-COV-2 and ACE2 in the pathophysiology of peripheral vascular diseases

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 166, P. 115321 - 115321

Published: Aug. 17, 2023

The occurrence of a novel coronavirus known as severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), created serious challenge worldwide. SARS-CoV-2 has high infectivity, the ability to be transmitted even during asymptomatic phase, and relatively low virulence, which resulted in rapid transmission. can invade epithelial cells, hence, many patients infected with have suffered from vascular diseases (VDs) addition pulmonary manifestations. Accordingly, may worsen clinical condition pre-existing VDs. Endothelial cells express angiotensin-converting enzyme 2 (ACE2). ACE2 is biological that converts angiotensin (Ang)- Ang-(1-7). uses cell receptor for viral entry. Thus, virus promotes downregulation ACE2, Ang-(1-7), anti-inflammatory cytokines, well as, an increase Ang-2, resulting pro-inflammatory cytokines. infection cause hypertension, endothelial damage, lead intravascular thrombosis. In this review, we concentrated on effect peripheral (PVDs) Renin-angiotensin aldosterone system (RAAS). A comprehensive search was performed PubMed, Google Scholar, Scopus, using related keywords. Articles focusing ("SARS-CoV-2", OR "COVID-19"), AND ("Vascular disease", "Peripheral interested disease name) regard MeSH terms, were selected. According studies, it supposed susceptibility due increased thrombotic burden dysfunction. Understanding mechanism pathogenesis crucial effective management treatment diseases.

Language: Английский

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The effect of synbiotic adjunct therapy on clinical and paraclinical outcomes in hospitalized COVID‐19 patients: A randomized placebo‐controlled trial

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(2)

Published: Jan. 5, 2023

Therapeutic approaches with immune-modulatory effects such as probiotics and prebiotics adjuvant therapy may be essential to combat against COVID-19 pandemic. The present trial aimed reveal the efficacy of synbiotic supplementation on clinical paraclinical outcomes hospitalized patients. current randomized placebo-controlled enrolled 78 patients confirmed infection. Participants were randomly allocated intervention control groups that received or placebo capsules twice daily for 2 weeks, respectively. capsule contains multi-strain Lactobacillus (L.) rhamnosus, L. helveticus, casei, Bifidobacterium (B.) lactis, acidophilus, B. breve, bulgaricus, longum, plantarum, bifidum, gasseri, Streptococcus (S.) thermophilus (109 CFU), well fructooligosaccharides prebiotic agent. Besides features, levels proinflammatory interleukin-6 (IL-6), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), liver renal function markers, hematological parameters, assessed during follow-up. serum level IL-6 was significantly decreased in group compared after weeks (p = 0.002). A significant difference found regarding count white blood cells (WBC) within from pre post-treatment 0.004). ESR 0.935) CRP 0.952) had a higher reduction trend relative placebo, no between-group differences. Other findings statistical differences between groups. Our results provide support can effective modulate inflammatory responses

Language: Английский

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Vitamin D, Albumin, and D-Dimer as Significant Prognostic Markers in Early Hospitalization in Patients with COVID-19

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(8), P. 2825 - 2825

Published: April 12, 2023

SARS-CoV-2 continues to pose a major challenge scientists and clinicians. We examined the significance of serum concentrations vitamin D, albumin, D-dimer for severity clinical picture mortality in COVID-19. Materials methods: A total 288 patients treated COVID-19 infection participated research. The were period from May 2020 January 2021. All divided based on need oxygen therapy (Sat > 94%) into with mild or severe pictures. biochemical radiographic parameters analyzed. Appropriate statistical methods used analysis. Results: In confirmed pictures, lower values albumin (p < 0.0005) D = 0.004) recorded, as opposed elevated 0.0005). Accordingly, fatal disease outcomes had levels 0.002), while their elevated. An increase score, parameter assessing picture, was accompanied by decrease simultaneous 0.0005), without change concentration 0.261). also demonstrated interrelations well predictors outcome disease. Conclusion: predictive our study indicates existence an important combined role early diagnosis most suffering Reduced combination D-dimer, can be timely indicators development death due

Language: Английский

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Assessment of Dietary and Lifestyle Quality Among the Romanian Population in the Post-Pandemic Period

Published: April 8, 2024

Background: The pandemic caused by the SARS-CoV-2 virus demonstrated importance of prevention through a healthy diet and lifestyle, most vulnerable people being those with severe chronic conditions, who are overweight, an unbalanced immune system. Methods: evaluation eating habits lifestyle Romanian population in post-pandemic period was carried out based on cross-sectional observational study help questionnaire. Results: 4704 valid answers were registered (3136 female 1568 male respondents). Among respondents, them belong to young population, 2892 between ages 18 40, i.e., 61.5%. Most respondents overweight (1400) obese (780). indicated tendency consume 1-2 meals per day irregularly (p=0.6167). Only 974 adopted diet, 578 lifestyle. Conclusion: present reports low adherence (20.7%) (12.28%), especially among (&amp;lt; 30 years). In current context, it reduced vegetables fruits below daily average recommended nutrition guidelines, towards sedentary behavior, even deficient hydration some respondents; these negative aspects can create long term series nutritional psycho-emotional imbalances. Our results evidence that complex surveys regularly required investigate or deficiencies; moreover, could be helpful further educational measures nutrition, food, environmental safety.

Language: Английский

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Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil

Bioengineering, Journal Year: 2022, Volume and Issue: 9(10), P. 584 - 584

Published: Oct. 20, 2022

Considering the imminence of new SARS-CoV-2 variants and COVID-19 vaccine availability, it is essential to understand impact disease on most vulnerable groups those at risk death from disease. To this end, odds ratio (OR) for mortality hospitalization was calculated different patients by applying an adjusted logistic regression model based following variables interest: gender, booster vaccination, age group, comorbidity occurrence. A massive number data were extracted compiled official Brazilian government resources, which include all reported cases hospitalizations deaths associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Brazil during “wave” Omicron variant (BA.1 substrain). Males (1.242; 95% CI 1.196–1.290) aged 60–79 (3.348; 3.050–3.674) 80 years or older (5.453; 4.966–5.989), hospitalized comorbidities (1.418; 1.355–1.483), more likely die. There a reduction (0.907; 0.866–0.951) among who had received third dose anti-SARS-CoV-2 (booster). Additionally, big investigation has found statistical evidence that vaccination can support mitigation plans concerning current scenario since its substrains are now prevalent across entire country.

Language: Английский

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