Susceptibility of Diabetic Patients to COVID-19 Infections: Clinico-Hematological and Complications Analysis

Vaccines, Journal Year: 2023, Volume and Issue: 11(3), P. 561 - 561

Published: March 1, 2023

Coronavirus disease 2019 has become a global health threat resulting in catastrophic spread and more than 3.8 million deaths worldwide. It been suggested that there is negative influence of diabetes mellites (DM), which complex chronic disease, on COVID-19 severe outcomes. Other factors diabetic patients may also contribute to outcomes, such as older age, obesity, hyperglycaemia, hypertension, other conditions.A cohort study was conducted the demographics, clinical information, laboratory findings hospitalised with DM non-DM were obtained from medical records King Faisal Specialist Hospital Research Centre, Saudi Arabia.Among population, 108 had DM, 433 patients. Patients likely present symptoms fever (50.48%), anorexia (19.51%), dry cough (47.96%), shortness breath (35.29%), chest pain (16.49%), symptoms. There significant decrease mean haematological biochemical parameters, haemoglobin, calcium, alkaline phosphate people compared non-diabetics considerable increase glucose, potassium, cardiac troponin.According this study, who have greater risk developing associated disease. This could result being admitted intensive care unit well higher mortality rates.

Language: Английский

---

Informatics-Driven Unsupervised Learning of Comorbidity Clusters for COVID-19 Reinfection Risk: A Finite Mixture Modeling Approach

Informatics in Medicine Unlocked, Journal Year: 2025, Volume and Issue: unknown, P. 101649 - 101649

Published: May 1, 2025

Language: Английский

---

Is Omicron really mild? – Comparative analysis of comorbidities and disease outcomes associated with SARS-CoV-2 Omicron (B.1.1.529) and Delta (B.1.617.2) variants

Indian Journal of Medical Microbiology, Journal Year: 2023, Volume and Issue: 45, P. 100391 - 100391

Published: June 6, 2023

Multiple variants of SARS-CoV-2 from Alpha to Omicron have an estimated 6.1 million deaths globally till date. These been found vary in transmissibility and severity. The present study deals with comparison morbidity mortality (B.1.1.529) Delta (B.1.617.2) variants. An observational retrospective cohort was conducted on a laboratory confirmed patients diagnosed by qRT-PCR nasopharyngeal swabs periods; April-2021 January-2022; that were sequenced recorded. Patients invited for telephonic interview after voluntary informed consent obtained each participant wherein, the demographics, co-morbidities, oxygen requirement outcomes enquired about. A total 200 patients, 100 period included study. Major comorbidities hypertension, diabetes mellitus pulmonary disease. who succumbed variant (26%) higher as compared (10%); elderly (68 ​± ​9.7 ​years) having significant during variant. increased hypertension (53.8%, 70%), (26.9%, 40%), chronic disease (30.8%, 20%), smoking (15.4%, 40%) infected both variants, respectively. concluded newer strains potential high milder population large, however, proportion adverse outcomes, irrespective

Language: Английский

---

Immune response against the SARS-CoV-2 spike protein in cancer patients after COVID-19 vaccination during the Omicron wave: a prospective study

Journal of Infection and Public Health, Journal Year: 2024, Volume and Issue: 17(7), P. 102473 - 102473

Published: June 7, 2024

Cancer patients often have weakened immune systems, resulting in a lower response to vaccines, especially those receiving immunosuppressive oncological treatment (OT). We aimed assess the impact of OT on humoral and T-cell B.1 lineage Omicron variant following COVID-19 vaccination with solid hematological neoplasms. conducted prospective study cancer patients, stratified into non-OT groups, who received two-dose series mRNA vaccine booster six months later. The outcomes measured were (anti-SARS-CoV-2 S IgG titers ACE2-S interaction inhibition capacity) cellular (SARS-CoV-2 S-specific spots per million PBMCs) responses against variant. These evaluated four weeks after second dose (n = 98) eight 71). was significantly weaker group compared (q-value<0.05). A mRNA-1273 improved group, making it comparable group. vaccine, designed for original Wuhan strain, elicited lineage, regardless or dose. In contrast, SARS-CoV-2, including variant, already present not affected by treatments. particularly treatments, should require doses adapted vaccines new SARS-CoV-2 variants like Omicron. Future studies evaluate durability efficacy individualized regimens.

Language: Английский

---

Impact of Acute Complications on The Course and Outcome of Severe COVID-19: a Clinical Analysis and Determination of Mortality Predictors

Ukrainian journal of cardiovascular surgery, Journal Year: 2025, Volume and Issue: 33(1), P. 103 - 111

Published: March 25, 2025

Aim. To establish the features of clinical picture, structure acute complications and predictors mortality in patients with a severe course COVID-19. Materials methods. 221 who were intensive care unit (ICU) City Clinical Hospital No. 1 Vinnytsia, Ukraine examined period 2020-2023. Among them, 133 (60.2%) survived 88 (39.8%) died as result COVID-19 (p = 0.02). Results. The rate was 39.8%. classified categories 6 7 by WHO, highest observed, (p<0.001). In group deceased patients, there significantly more hypertension (73 (83.0%) vs. 90 (67.7%), p=0.008), coronary heart disease (CHD) (83 (94.3%) 91 (68.4%)), p 0.0001), combination CAD (72 (81.8%) 79 (59.4%), < 0.001). addition, acute/chronic kidney diseases (18 (20.5%) 13 (9.8%), 0.022) cancer common (12 (13.6%) 8 (6.0%)), 0.046). that occurred during stay ICU, experienced higher rates following conditions: stroke (10 (11.4%) 3 (2.3%), 0.006), failure (9 (10.2%) 4 (3.0%), 0.038), pulmonary embolism 0.014), infectious toxic shock (0.8%), 0.001), respiratory distress syndrome (78 (88.6%) (4.5%), endstage renal (62 (80.5%) 82 (62.1%), 0.006). Additionally, among rhythm disturbances, atrial fibrillation prevalent associated lower survival (31 (35.2%) 19 (14.3%), 0.0001). Conclusions. study demonstrated factors include patient age с omorbidity such hypertension, CAD, disorders. Tachyarrhythmias bradyarrhythmias often observed particular, they had frequent AF, which emphasizes its role predictor poor prognosis

Language: Английский

---

Viral Infections in Elderly Individuals: A Comprehensive Overview of SARS-CoV-2 and Influenza Susceptibility, Pathogenesis, and Clinical Treatment Strategies

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 431 - 431

Published: April 21, 2025

As age increases, the immune function of elderly individuals gradually decreases, increasing their susceptibility to infectious diseases. Therefore, further research on common viral infections in population, especially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses, is crucial for scientific progress. This review delves into genetic structure, infection mechanisms, impact coinfections with these two viruses provides a detailed analysis reasons increased dual infections. We evaluated clinical manifestations following coinfections, including complications respiratory, gastrointestinal, nervous, cardiovascular systems. Ultimately, we have summarized current strategies prevention, diagnosis, treatment SARS-CoV-2 older adults. Through studies, aim reduce risk provide basis age-related diseases, thereby improving health status.

Language: Английский

---

Exploring the therapeutic potential of Thymus vulgaris ethanol extract: a computational screening for antimicrobial compounds against COVID-19 induced mucormycosis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 7, 2025

Language: Английский

---

Mechanisms and potential roles of active ingredients of traditional Chinese medicine in the treatment of chronic obstructive pulmonary disease

Journal of Pharmacy and Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Abstract Objectives Chronic obstructive pulmonary disease (COPD) is a respiratory condition with high rates of morbidity and mortality. Recent studies have shown that the increasing research on Traditional Chinese Medicine (TCM) also plays an important role in COPD. The purpose this review to categorize TCM its active ingredients summarize their pharmacological effects. Methods Articles published up December 2024 were searched through PubMed, X-MOL, China National Knowledge Infrastructure. keywords included combination COPD, pharmacologic activity, anti-inflammatory effects, pharmacology, as well vivo vitro studies. Key findings Thus far, we summarized progress mechanisms action ingredients, such flavonoids, terpenoids, phenols, treatment These encompass reduction inflammatory responses lung injury, regulation oxidation-antioxidation balance, modulation cellular apoptosis aging, among other Conclusion demonstrate strong anti-COPD properties. This provides reference for accelerating development herbal components COPD exploring new potential multi-target therapeutic mechanisms. will mitigate geographical limitations using enhance application future management strategies.

Language: Английский

---

Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2

Biochimie, Journal Year: 2022, Volume and Issue: 201, P. 139 - 147

Published: June 17, 2022

Language: Английский

---

The Association between Fear of COVID-19 and Health-Related Quality of Life: A Cross-Sectional Study in the Greek General Population

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(11), P. 1891 - 1891

Published: Nov. 11, 2022

The aim of this cross-sectional study was to assess the level fear related SARS-CoV-2 virus and association fear, sociodemographic clinical characteristics, with health-related quality life (HRQoL). A large sample Greek general population (N = 583) completed validated versions Fear COVID-19 scale (FCV-19s) 12-item Short Form (SF-12), provided data on socio-demographic status, health history protective behaviors. Variables were compared Mann-Whitney Kruskal-Wallis tests associations Spearman’s correlations. Gamma regression models investigated influence COVID-related variables HRQoL. mean FCV-19s score for 18.3 ± 5.6, physical mental component summary scores 50.2 7.9 46.7 10.1, respectively. More expressed by females (p < 0.001), individuals comorbidities 0.01), those contacts not having caught 0.05). Contrastingly, less unvaccinated frequent intake information about pandemic. Item overall negatively associated SF-12 scores, most important predictor both findings from other similar studies could help identify specific groups in need interventions improve their health, which had deteriorated due

Language: Английский

---