Several
symbiotic
microbes
remain
in
the
gastrointestinal
tract
of
humans
and
animals.These
micro-organisms
are
beneficial
because
their
assisting
role
digestion,
preventing
pathogens'
entry,
blocking
harmful
pathogens,
providing
several
functional
molecules
to
organisms.The
irrational
use
antimicrobial
chemical
drugs,
increased
consumption
junk
food,
low-pH
carbonated,
alcoholic,
or
caffeinated
energy
drinks
have
led
severe
destruction
microflora.This
microflora
has
made
animals
susceptible
pathogens
which
can
kill
host.Management
this
issue
be
done
by
suitable
alternatives
medicine
at
least
control
its
delivery
target
only
so
that
normal
may
not
disturbed.Among
all
suggested
methods,
nanoparticles
promising
importance.Nanoparticles
nanometer-scale
particles
metals
metallic
compounds
deliver
drug,
nutraceuticals,
any
other
agent
inside
body.They
act
as
carriers
themselves
serve
active
body.Research
suggests
for
improvement
microbiota
they
specific
sites,
easy
elimination,
maintaining
controlled
release
antimicrobials,
enhancing
immunity.Research
is
being
manage
dosages
usages.This
chapter
highlights
importance
nanoparticles,
body,
potential
enhancements
immunity
body.
Drugs and Drug Candidates,
Journal Year:
2023,
Volume and Issue:
2(2), P. 516 - 537
Published: June 17, 2023
Inflammation
is
an
essential
defense
mechanism
against
harmful
stimuli.
However,
uncontrolled
inflammatory
mechanisms
culminate
in
disturbed
responses
that
contribute
to
multiple
serious
diseases.
Besides
common
synthetic
drugs,
there
a
growing
interest
optimizing
the
use
of
natural
products
as
therapeutic
or
protective
supplements
disorders.
Black
cumin
seed
(BCS),
Nigella
sativa
(Family
Ranunculaceae),
widely
used
health-supportive
herb
Middle
East,
Far
East
and
West
Asia.
BCS
rich
source
phytochemicals,
studies
have
reported
its
promising
effects
variety
metabolic,
proliferative,
respiratory,
neurological
disorders
associated
with
disrupted
pathways.
This
review
presents
updated
comprehensive
assessment
BCS’s
various
highlights
role
bioactive
constituents
inflammation
oxidative
stress
Moreover,
it
outlines
future
possibilities
for
enhancing
activity
through
efficient
pharmaceutical
formulations.
Thorough
analysis
international
research
published
between
years
1998
2023
reveals
anti-inflammatory
potential
modulating
crucial
players
Thus,
can
be
further
boosted
by
technologies
such
nano-incorporation
improved
management
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: June 27, 2024
Introduction:
This
study
explores
the
therapeutic
potential
of
silver
nanoparticles
(Ag
NPs)
synthesized
using
a
Helianthemum
lippii
extract
in
mitigating
cadmium-induced
hepatotoxicity
Wistar
rats.
Given
increasing
environmental
and
health
concerns
associated
with
cadmium
exposure,
novel
eco-friendly
strategies
are
essential.
Methods:
Ag
NPs
were
characterized
X-ray
diffraction,
UV-Vis
spectrometry,
energy-dispersive
spectroscopy
scanning
electron
microscopy,
confirming
their
formation
cubic
crystal
structure
particle
sizes
ranging
from
4.81
to
12.84
nm.
A
sub-acute
toxicity
(2
mg/kg
10
mg/kg)
was
conducted,
showing
no
significant
difference
compared
untreated
control
rats
(
n
=
3
animals/group).
Subsequently,
adult
5/group)
divided
into
group
three
experimental
groups:
alone,
exposure
50
CdCl
2
drinking
water
for
35
days,
followed
by
0.1
mg/kg/day
intraperitoneally
15
days.
Results:
In
-exposed
group,
there
decrease
body
weight
increases
alanine
aspartate
transaminase
levels
p
<
0.05
vs.
control),
indicating
hepatotoxicity.
Additionally,
antioxidant
defenses
decreased,
malondialdehyde
elevated.
Liver
histology
revealed
portal
fibrosis,
inflammation,
necrosis,
sinusoid
hepatic
vein
dilation,
cytoplasmic
vacuolations.
Treatment
post-CdCl
mitigated
several
adverse
effects
on
liver
function
architecture
improved
weight.
Discussion:
demonstrates
efficacy
via
green
method
reducing
damage.
These
findings
support
applications
highlight
importance
sustainable
nanoparticle
synthesis
methods.
By
addressing
both
efficacy,
this
research
aligns
growing
emphasis
environmentally
conscious
practices
scientific
healthcare.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(19)
Published: May 15, 2024
Abstract
Infectious
diseases
are
becoming
a
worldwide
threat
due
to
antibiotic
resistance.
Therefore,
it
is
necessary
prepare
innovative
antibiotics
against
bactericidal
activities.
The
development
of
nanomedicine
has
been
greatly
aided
by
nanotechnology.
A
focal
point
exploration
involves
the
production
noble
metal
nanoparticles,
owing
their
diverse
applications.
study's
subjects
synthesis,
characterization,
and
assessment
silver
nanoparticles
(AgNPs)
derived
from
Berberis
lyceum
Royle
root
bark
(BLR)
extract.
study
revealed
potent
antibacterial
properties
BLR‐AgNPs,
with
heightened
efficacy
S.
pyogenes
(16.7±0.3
mm)
comparatively
lower
activity
E.
coli
(1.1±0.1
mm).
Minimum
inhibitory
concentration
indicated
maximum
at
10
μg/mL,
whereas
2.5
μg/mL
demonstrated
least
effect.
Furthermore,
wound
healing
potential
BLR‐AgNPs
was
explored,
demonstrating
superior
(0.19±0.02
cm)
equated
BLR‐extract
(0.46±0.02
untreated
wounds
(0.77±0.02
cm).
These
findings
underscore
considerable
wound‐healing
capabilities
BLR‐AgNPs.
Processes,
Journal Year:
2025,
Volume and Issue:
13(1), P. 168 - 168
Published: Jan. 9, 2025
This
study
was
aimed
at
extracting,
characterizing,
and
exploring
the
detoxification
activity
of
peptide-containing
polysaccharide
from
Agaricus
balchaschensis.
An
anion
adsorption
fraction
acquired
through
hot
water
extraction.
Its
structure
analyzed,
potential
protective
effect
against
cadmium-intoxicated
mice
explored.
Structural
analysis
revealed
that
principal
component
A.
balchaschensis
(ABPCP)
is
polysaccharide,
which
consists
glucose,
mannose,
galactose,
xylose,
containing
(1
→
4)-linked
α-D-glucan,
3)-linked
β-D-Glcp,
6)-linked
β-D-Manp,
β-D-Galp,
β-D-xylan.
The
amino
acid
content
ABPCP
11.747
mg/g.
Threonine,
serine,
glutamate,
glycine,
alanine,
cysteine,
valine,
methionine,
lysine,
arginine
were
detected
in
ABPCP,
among
glutamate
highest.
alleviating
on
cadmium
poisoning
investigated.
significantly
reduced
serum
heart,
kidneys,
liver,
indicates
could
promote
discharge.
also
decreased
nitric
oxide,
endothelin-1,
urea,
uric
acid,
creatinine,
kidney
liver
damage
caused
by
cadmium.
All
these
results
manifest
can
lower
organs
alleviate
to
kidneys
livers
damaged
Cd.
As
humans,
plants,
and
animals
are
exposed
to
more
chemical
pollutants,
environmental
pollution
has
become
a
concern
for
humans.
Humans,
often
single
mixed
chemicals
that
present
in
the
environment.
Chemical
properties,
production,
corresponding
main
sources
of
pollution/toxic
effects
evaluation
aspects
health
assessment.
This
chapter
provides
an
overview
toxicological
several
major
contaminants
environment,
using
mixtures
as
entry
point
zebrafish
mice
research
objects.
The
pollutants
on
target
organs,
i.e.
heart,
nerves,
blood
vessels,
liver,
kidneys
analyzed.
study
contributes
in-depth
mechanisms
toxicity
organism.
Frontiers in Nanotechnology,
Journal Year:
2025,
Volume and Issue:
6
Published: Jan. 28, 2025
The
liver
and
kidneys
are
vital
organs
responsible
for
essential
metabolic
excretory
functions,
their
protection
is
a
cornerstone
of
therapeutic
innovation.
This
review
highlights
the
emerging
role
eco-friendly,
bioengineered
silver
(AgNPs)
gold
nanoparticles
(AuNPs)
as
protective
agents
kidney
health,
based
on
evidence
from
animal
studies.
discussion
emphasizes
green
synthesis
approaches,
which
offer
sustainable
biocompatible
routes
nanoparticle
production.
Key
findings
reveal
effects
these
(NPs)
hepatic
enzymes—Aspartate
aminotransferase
(AST),
Alanine
transaminase
(ALT),
Alkaline
phosphatase
(ALP)—and
renal
function
markers,
including
urea
creatinine
levels,
under
both
healthy
pathological
conditions.
In
diseased
models,
biosynthesized
NPs
significantly
reduced
ALT,
AST,
ALP,
urea,
demonstrating
effects.
Conversely,
in
animals,
lower
concentrations
exhibited
no
statistically
significant
impact
parameters,
suggesting
safety
at
doses.
presents
novelty
potential
while
highlighting
need
further
research
into
pharmacokinetics
pharmacodynamics
to
advance
clinical
translation.
Microscopy Research and Technique,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
The
green
methods
for
the
synthesis
of
silver
nanoparticles
(AgNPs)
has
developed
popularity
recently
due
to
low
preparation
costs,
environmental
friendliness,
and
non-toxicity
precursors.
In
this
study,
AgNPs
were
synthesized
using
leaf
extract
from
Merremia
quinquefolia.
Spectroscopic
techniques
used
analyzing
functional
groups,
morphology,
crystalline
phase,
elemental
composition
nanomaterials.
ultraviolet
(UV)
visible
spectrometry
absorption
spectra
had
a
surface
plasmon
resonance
band
at
459
nm
Fourier
transformed
infrared
spectrum
(FTIR)
analysis
showed
presence
elements
groups.
X-ray
diffraction
(XRD)
indicates
structure
energy-dispersive
x-ray
spectroscopy
(EDAX)
shows
strong
signals
element.
Morphological
transmission
electron
microscope
(TEM)
scanning
microscopy
(SEM)
analyses
revealed
that
exhibited
spherical
shapes
with
an
average
size
14
nm.
Furthermore,
it
was
indicated
by
Raman
vibrational
peak
240
470
cm-1.
disk
diffusion
method
highly
effective
in
inhibition
Gram-positive
bacteria
Staphylococcus
aureus
high
inhibitory
zone
(14
±
0.23
mm).
Antioxidant
activity,
IC50
values
assays
DPPH
(145.7
μg/mL)
ABTS
(112.09
μg/mL),
albumin
denaturation
human
red
blood
cells
higher
anti-inflammatory
activity.
value
4.62
μg/mL
against
breast
cancer
(MCF-7)
cells.
Methylene
blue
(MB)
degrading
studies
assess
photocatalytic
activity
AgNPs.
They
are
min
observed
sunlight,
MB
degradation
efficiency
94.89%.
Overall,
although
M.
quinquefolia
synthesizes
environmentally
friendly
applications,
study
is
fully
understand
potential
involved
treating
