Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 162 - 180
Published: Nov. 21, 2024
Language: Английский
Bioactive Materials, Journal Year: 2023, Volume and Issue: 27, P. 15 - 57
Published: March 27, 2023
Titanium (Ti) and its alloys have been widely used as orthopedic implants, because of their favorable mechanical properties, corrosion resistance biocompatibility. Despite significant success in various clinical applications, the probability failure, degradation revision is undesirably high, especially for patients with low bone density, insufficient quantity or osteoporosis, which renders studies on surface modification Ti still active to further improve results. It discerned that physicochemical properties directly influence even control dynamic interaction subsequently determines rejection implants. Therefore, it crucial endow bulk materials specific high bioactivity can be performed by realize osseointegration. This article first reviews characteristics conventional techniques involving mechanical, physical chemical treatments based formation mechanism modified coatings. Such methods are able but surfaces static state cannot respond biological cascades from living cells tissues. Hence, beyond traditional design, responsive avenues then emerging. The stimuli sources functionalization originate environmental triggers physiological triggers. In short, this review surveys recent developments engineering materials, a emphasis advances functionality, provides perspectives improving biocompatibility
Language: Английский
Citations
101
Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 39, P. 102178 - 102178
Published: July 1, 2024
Inflammatory arthritis is a growing worldwide concern, afflicting millions of individuals and leading to depreciating quality life, significant morbidity, subsequent healthcare burden. Conventional therapies for inflammatory often hold limitations, including systemic cross-reactivities, side effects, inadequate management inflammation. Therefore, "Smart" stimuli-responsive biomaterials are materialized as promising theranostic approaches management. These designed specific external internal stimulation, enabling the sustained release bioactive therapeutic agents during local or administration. Stimuli-responsive allow precise spatiotemporal control over drug release, minimizing exposure, reducing off-target real-time monitoring pathological conditions, driving potential breakthrough in managing arthritis. Owing this prominence, review article expounds on emerging prospects targeting molecular signatures associated with intricately elicit minimal no contradictory effects. In addition, application these disease progression multi-stimuli-responsive comprehended show progress diagnosis treatment. This "single-platted" comprehensive acquaintance clinical-based outcomes navigates microenvironment, proposing an optimistic avenue personalized effective minimized
Language: Английский
Citations
19
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Abstract Lattice metamaterials emerge as advanced architected materials with superior physical properties and significant potential for lightweight applications. Recent developments in additive manufacturing (AM) techniques facilitate the of lattice intricate microarchitectures promote their applications multi‐physical scenarios. Previous reviews on have largely focused a specific/single field, limited discussion properties, interaction mechanisms, multifunctional Accordingly, this article critically design principles, structure‐mechanism‐property relationships, enabled by AM techniques. First, are categorized into homogeneous lattices, inhomogeneous other forms, whose principles processes discussed, including benefits drawbacks different fabricating types lattices. Subsequently, structure–mechanism–property relationships mechanisms range fields, mechanical, acoustic, electromagnetic/optical, thermal disciplines, summarized to reveal critical principles. Moreover, metamaterials, such sound absorbers, insulators, manipulators, sensors, actuators, soft robots, management, invisible cloaks, biomedical implants, enumerated. These provide effective guidelines
Language: Английский
Citations
6
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 26, 2025
Porous titanium implants are becoming an important tool in orthopedic clinical applications. This review provides a comprehensive survey of recent advances porous for use. First, the briefly describes characteristics bone and design requirements implants. Subsequently, pore size structural alloy materials presented, then we introduce application practice, including spine surgery, joint treatment tumors. Following that, describe surface modifications applied to obtain better biological functions. Finally, discuss incorporating environmental responsive mechanisms into achieve additional functionalities.
Language: Английский
Citations
2
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(24)
Published: Feb. 19, 2024
Abstract Bone implant biomaterials are among the most used materials for clinical application. Despite significant advances in biocompatibility and osteoconductivity, conventional lack ability to cope with pathological microenvironment (inflammation, infection, residual tumors, etc.) during bone repair. Semiconductor have unique electrical, optical, ultrasound, thermal response properties, which facilitate non‐invasively controllably dynamic repair of defects. In this review, design synthesis a new generation semiconductor‐driven summarized, mechanism action semiconductive biomaterials' functional interfaces process tissues discussed, strategies problems encountered osseointegration is provided. Finally, review outlooks future implants defect
Language: Английский
Citations
13
Progress in Additive Manufacturing, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 12, 2024
Abstract In recent years, four-dimensional (4D) fabrication has emerged as a powerful technology capable of revolutionizing the field tissue engineering. This represents shift in perspective from traditional engineering approaches, which generally rely on static—or passive—structures (e.g., scaffolds, constructs) unable adapting to changes biological environments. contrast, 4D offers unprecedented possibility fabricating complex designs with spatiotemporal control over structure and function response environment stimuli, thus mimicking processes. this review, an overview state art for obtainment cellularized constructs is presented, focus shape-changing soft materials. First, approaches obtain are introduced, also describing conventional non-conventional techniques their relative advantages limitations. Next, main families materials, namely shape-memory polymers hydrogels discussed use described. Ultimately, current challenges proposed solutions outlined, valuable insights into future research directions provided disclose its full potential.
Language: Английский
Citations
9
ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 25, 2025
Electrorheological fluids (ER) make up a class of smart materials that are distinguished by their capacity to alter rheological characteristics in controlled and reversible manner response an externally applied electric field (E). As inherent polarizable anhydrous ER-active material, polyaniline (PAni)-based among the most frequently utilized materials. However, PAni can only be used as material after carefully adjusting its conductivity appropriate range. Three-dimensional (3D) conjugated microporous polymer (CMP) analogs have nitrogen-rich porous hierarchical structure, low density, explore ER performance dispersion stability. In this study, carboxylic acid functionalized version with greater polar surface was designed obtain higher polarizability without need for any dedoping process thus enhanced performance. For purpose, polytriphenylamine (PTPA) extended carboxylic-acid-functionalized PTPA (PTPA-COOH) were synthesized Buchwald–Hartwig cross-coupling. The structural, morphological, electrical, microstructural, properties investigated detail before determined. Dispersions CMPs prepared silicon oil examined under different E values measuring shear stress, viscosity, moduli values. PTPA-COOH 10 wt % concentration exhibited excellent stability 99% performance, including high stress (static yield 370 Pa at 3.5 kV/mm), repeatable response, obvious dielectric loss peak (relaxation time 0.01 s). This 3D shows significant promise applications fluids.
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160524 - 160524
Published: Feb. 1, 2025
Language: Английский
Citations
1
Applied Physics Reviews, Journal Year: 2025, Volume and Issue: 12(1)
Published: March 1, 2025
Smart biomaterials have significantly impacted human healthcare by advancing the development of medical devices designed to function within tissue, mimicking behavior natural tissues. While intelligence has evolved from inert active over past few decades, smart take this a step further making their surfaces or bulk respond based on interactions with surrounding tissues, imparting outcomes similar tissue functions. This interaction helps in creating stimuli-responsive biomaterials, which can be useful engineering, regenerative medicine, autonomous drug delivery, orthopedics, and much more. Traditionally, material engineering focused refining static properties accommodate them body without evoking an immune response, was major obstacle unrestricted operation. review highlights explains various approaches currently under research for developing that tune responses bodily factors like temperature, pH, ion concentration external magnetism, light, conductivity. Applications soft hard 4D printing, scaffold design are also discussed. The advanced application microfluidics, organ-on-a-chip models, extensively benefits intrinsic discussed below. elaborates how biomaterial could revolutionize biosensor applications, thereby improving patient care quality. We delineate limitations key challenges associated providing insights into path forward outlining future directions next-generation will facilitate clinical translation.
Language: Английский
Citations
1
Current Opinion in Biomedical Engineering, Journal Year: 2023, Volume and Issue: 26, P. 100440 - 100440
Published: Jan. 2, 2023
Language: Английский
Citations
18