Morin-Based Nanoparticles for Regulation of Blood Glucose DOI

Ziqi Hua,

Yanfei Li, Tao Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(17), P. 21400 - 21414

Published: April 19, 2024

Morin, a naturally occurring bioactive compound shows great potential as an antioxidant, anti-inflammatory agent, and regulator of blood glucose levels. However, its low water solubility, poor lipid limited bioavailability, rapid clearance in vivo hinder application regulation. To address these limitations, we report enzymatically synthesized nanosized morin particle (MNs) encapsulated sodium alginate microgels (M@SA). This approach significantly enhances morin's delivery efficiency therapeutic efficacy Utilizing horseradish peroxidase, MNs averaging 305.7 ± 88.7 nm size. These were then via electrohydrodynamic microdroplet spraying to form M@SA microgels. In studies revealed that demonstrated prolonged intestinal retention superior compared with unmodified alone. Moreover, notably improved uptake HepG2 cells. Furthermore, effectively regulated glucose, profiles, oxidative stress diabetic mice while mitigating liver, kidney, pancreatic damage enhancing responses. Our findings propose promising strategy for the oral administration natural compounds regulation, implications broader applications.

Language: Английский

Curcumin-stabilized silver nanoparticles encapsulated in biocompatible electrospun nanofibrous scaffold for sustained eradication of drug-resistant bacteria DOI
Ling Cai, Xinyi Zhu, Hongjie Ruan

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 452, P. 131290 - 131290

Published: March 24, 2023

Language: Английский

Citations

57
Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience DOI Creative Commons

Leili Shabani,

Milad Abbasi,

Zeynab Azarnew

et al.

BioMedical Engineering OnLine, Journal Year: 2023, Volume and Issue: 22(1)

Published: Jan. 2, 2023

Abstract Artificial, de-novo manufactured materials (with controlled nano-sized characteristics) have been progressively used by neuroscientists during the last several decades. The introduction of novel implantable bioelectronics interfaces that are better suited to their biological targets is one example an innovation has emerged as a result advanced nanostructures and interfaces, which increased potential prostheses neural interfaces. unique physical–chemical properties nanoparticles also facilitated development imaging instruments for laboratory systems, well intelligently scaffolds microelectrodes other technologies designed increase our understanding tissue processes. incorporation nanotechnology into physiology cell biology enables tailoring molecular interactions. This involves interactions with neurons glial cells in neuroscience. Technology solutions intended effectively interact neuronal cells, improved molecular-based diagnostic techniques, biomaterials hybridized compounds utilized regeneration, neuroprotection, targeted delivery medicines small chemicals across blood–brain barrier all purposes present article.

Language: Английский

Citations

38
Lipidic lyotropic liquid crystals: Insights on biomedical applications DOI Creative Commons

Guillermo Blanco-Fernández,

Bárbara Blanco‐Fernandez, Anxo Fernández‐Ferreiro

et al.

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 313, P. 102867 - 102867

Published: Feb. 28, 2023

Liquid crystals (LCs) possess unique physicochemical properties, translatable into a wide range of applications. To date, lipidic lyotropic LCs (LLCs) have been extensively explored in drug delivery and imaging owing to the capability encapsulate release payloads with different characteristics. The current landscape LLCs biomedical applications is provided this review. Initially, main types, methods fabrication are showcased. Then, comprehensive discussion accordingly application (drug biomacromolecule delivery, tissue engineering molecular imaging) route administration examined. Further limitations perspectives also provided. those systems between solid liquid state that morphological A short description properties LCs, their types manufacturing procedures given serve as background topic. latest most innovative research field biomedicine examined, specifically areas imaging. Finally, prospects discussed show future trends might be utilized. This article an ampliation, improvement actualization our previous forum "Bringing crystal technology biomedicine" published TIPS.

Language: Английский

Citations

29
Potential of Nano-Antioxidants and Nanomedicine for Recovery from Neurological Disorders Linked to Long COVID Syndrome DOI Creative Commons
Thelma Akanchise, Angelina Angelova

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 393 - 393

Published: Feb. 6, 2023

Long-term neurological complications, persisting in patients who cannot fully recover several months after severe SARS-CoV-2 coronavirus infection, are referred to as sequelae of the long COVID syndrome. Among numerous clinical post-acute COVID-19 symptoms, and psychiatric manifestations comprise prolonged fatigue, "brain fog", memory deficits, headache, ageusia, anosmia, myalgias, cognitive impairments, anxiety, depression lasting months. Considering that neurons highly vulnerable inflammatory oxidative stress damages following overproduction reactive oxygen species (ROS), neuroinflammation have been suggested dominate pathophysiological mechanisms It is emphasized mitochondrial dysfunction crucial for pathogenesis neurodegenerative disorders. Importantly, antioxidant therapies potential slow down prevent disease progression. However, many compounds display low bioavailability, instability, transport targeted tissues, limiting their applications. Various nanocarrier types, e.g., liposomes, cubosomes, solid lipid nanoparticles, micelles, dendrimers, carbon-based nanostructures, nanoceria, other inorganic can be employed enhance bioavailability. Here, we highlight phytochemical antioxidants neuroprotective agents (curcumin, quercetin, vitamins C, E D, melatonin, rosmarinic acid, N-acetylcysteine, Ginkgo Biloba derivatives) therapeutic strategies neuroregeneration. A particular focus given beneficial role nanoparticle-mediated drug-delivery systems addressing challenges managing preventing disorders factors sequelae.

Language: Английский

Citations

26
Liposomes to Cubosomes: The Evolution of Lipidic Nanocarriers and Their Cutting-Edge Biomedical Applications DOI Creative Commons

Nishtha Attri,

Swarnali Das, Jhimli Banerjee

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 2677 - 2694

Published: April 13, 2024

Lipidic nanoparticles have undergone extensive research toward the exploration of their diverse therapeutic applications. Although several liposomal formulations are in clinic (e.g., DOXIL) for cancer therapy, there many challenges associated with traditional liposomes. To address these issues, modifications structure and further functionalization desirable, leading to emergence solid lipid more recent liquid nanoparticles. In this context, "cubosomes", third-generation lipidic nanocarriers, attracted significant attention due numerous advantages, including porous structure, structural adaptability, high encapsulation efficiency resulting from internal surface area, enhanced stability, biocompatibility. Cubosomes offer potential both cellular uptake controlled release encapsulated payloads. Beyond cubosomes demonstrated effectiveness wound healing, antibacterial treatments, various dermatological review, authors provide an overview evolution spanning conventional liposomes nanoparticles, a special emphasis on development application cubosomes. Additionally, it delves into applications preclinical trials cubosome formulations, which could be interest readers backgrounds nanomedicine clinicians.

Language: Английский

Citations

9
Investigating the Efficacy of Liquid Crystal Nano Cubosomes Containing Dorzolamide and Timolol for Drug Delivery to the Cornea DOI

Nadia Mostafavi Nezhad,

Hossein Kamali, Ali Asghar Sarchahi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106724 - 106724

Published: Feb. 17, 2025

Language: Английский

Citations

1
Development, evaluation, pharmacokinetic and biodistribution estimation of resveratrol-loaded solid lipid nanoparticles for prostate cancer targeting DOI
Alok Nath Sharma, Prabhat Kumar Upadhyay, Hitesh Kumar Dewangan

et al.

Journal of Microencapsulation, Journal Year: 2022, Volume and Issue: 39(6), P. 563 - 574

Published: Aug. 18, 2022

The study was to extend systemic circulation and biological half-life (t1/2) of trans-resveratrol (RSV) using solid lipid nanoparticles (RSV-SLN) improve its anti-cancer potential.RSV-SLN prepared by solvent emulsification evaporation technique proceeded for evaluation like particle size, PDI, zeta potential, in vitro release, cytotoxicity, cellular internalisation, haemolysis erythrocyte membrane integrity, platelet aggregation pharmacokinetic studies rats. Moreover, cancer cells accumulation RSV-SLN also needs be evaluated proving their targeting ability.Prepared SLN showed 126.85 ± 12.09 nm -24.23 3.27 mV Zeta potential 74.67 4.76%. release at 48 h haemocompatible. internalisation image the reach a cytoplasm nucleus PC3 prostate cells. exhibited high t1/2 (8.22 1.36 h) 7.19 0.69 MRT (Mean residence time) lower clearance i.e. 286.42 13.64 mL/min/kg. bio-distribution found extremely accumulate 7.56 times greater than that RSV solution.The developed can applied as carrier delivery drug chemotherapeutics an efficiency tumour site.

Language: Английский

Citations

37
Recent Uses of Lipid Nanoparticles, Cell-Penetrating and Bioactive Peptides for the Development of Brain-Targeted Nanomedicines against Neurodegenerative Disorders DOI Creative Commons
Yu Wu, Angelina Angelova

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(23), P. 3004 - 3004

Published: Nov. 23, 2023

The lack of effective treatments for neurodegenerative diseases (NDs) is an important current concern. Lipid nanoparticles can deliver innovative combinations active molecules to target the various mechanisms neurodegeneration. A significant challenge in delivering drugs brain ND treatment associated with blood–brain barrier, which limits effectiveness conventional drug administration. Current strategies utilizing lipid and cell-penetrating peptides, characterized by uptake mechanisms, have potential extend residence time bioavailability encapsulated drugs. Additionally, bioactive neurotropic or neuroprotective properties be delivered potentially mediate targeting pathways, e.g., neurotrophin deficiency, impaired metabolism, mitochondrial dysfunction, endoplasmic reticulum stress, accumulation misfolded proteins peptide fragments, toxic protein aggregates, oxidative stress damage, neuroinflammation. This review discusses recent advancements CPPs view integration these two approaches into nanomedicine development dual-targeted nanoparticulate systems delivery disorders.

Language: Английский

Citations

21
Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy DOI Creative Commons
Thelma Akanchise, Angelina Angelova

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1562 - 1562

Published: May 22, 2023

Coronavirus infections are neuroinvasive and can provoke injury to the central nervous system (CNS) long-term illness consequences. They may be associated with inflammatory processes due cellular oxidative stress an imbalanced antioxidant system. The ability of phytochemicals anti-inflammatory activities, such as Ginkgo biloba, alleviate neurological complications brain tissue damage has attracted strong ongoing interest in neurotherapeutic management long COVID. biloba leaf extract (EGb) contains several bioactive ingredients, e.g., bilobalide, quercetin, ginkgolides A–C, kaempferol, isorhamnetin, luteolin. have various pharmacological medicinal effects, including memory cognitive improvement. through its anti-apoptotic, antioxidant, impacts function other conditions like those While preclinical research on therapies for neuroprotection shown promising results, clinical translation remains slow challenges (e.g., low drug bioavailability, limited half-life, instability, restricted delivery target tissues, poor capacity). This review emphasizes advantages nanotherapies using nanoparticle approaches overcome these challenges. Various experimental techniques shed light molecular mechanisms underlying response help comprehend pathophysiology sequelae SARS-CoV-2 infection. To develop novel therapeutic agents systems, methods mimicking been used lipid peroxidation products, mitochondrial respiratory chain inhibitors, models ischemic damage). We hypothesize beneficial effects EGb COVID-19 symptoms, evaluated either vitro or vivo animal stress.

Language: Английский

Citations

17
Nanotechnology in the diagnostic and therapy for Alzheimer's disease DOI

Archna Panghal,

S.J.S. Flora

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2024, Volume and Issue: 1868(3), P. 130559 - 130559

Published: Jan. 6, 2024

Language: Английский

Citations

7