Inflammatory responses and inflammation-associated diseases in organs

Oncotarget, Journal Year: 2017, Volume and Issue: 9(6), P. 7204 - 7218

Published: Dec. 14, 2017

// Linlin Chen 1, * , Huidan Deng Hengmin Cui 2 Jing Fang Zhicai Zuo Junliang Yinglun Li Xun Wang and Ling Zhao 1 College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China Key Laboratory Animal Diseases Environmental Hazards Province, Agriculture These authors contributed equally to this work Correspondence to: Cui, email: [email protected] Keywords: inflammation; inflammatory signaling pathways; chemokines; cytokines; organ diseases Received: April 19, 2017      Accepted: November 03, Published: December 14, 2017 ABSTRACT Inflammation is a biological response the immune system that can be triggered by variety factors, including pathogens, damaged cells toxic compounds. factors may induce acute and/or chronic responses in heart, pancreas, liver, kidney, lung, brain, intestinal tract reproductive system, potentially leading tissue damage or disease. Both infectious non-infectious agents cell activate trigger pathways, most commonly NF-κB, MAPK, JAK-STAT pathways. Here, we review within organs, focusing on etiology inflammation, mechanisms, resolution organ-specific responses.

Language: Английский

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ERK/MAPK signalling pathway and tumorigenesis (Review)

Experimental and Therapeutic Medicine, Journal Year: 2020, Volume and Issue: unknown

Published: Jan. 15, 2020

Mitogen‑activated protein kinase (MAPK) cascades are key signalling pathways that regulate a wide variety of cellular processes, including proliferation, differentiation, apoptosis and stress responses. The MAPK pathway includes three main kinases, kinase, MAPK, which activate phosphorylate downstream proteins. extracellular signal‑regulated kinases ERK1 ERK2 evolutionarily conserved, ubiquitous serine‑threonine under both normal pathological conditions. ERK expression is critical for development their hyperactivation plays major role in cancer progression. Ras/Raf/MAPK (MEK)/ERK the most important cascade among all signal transduction pathways, crucial survival tumour cells. present review discusses recent studies on Ras members. With respect to processes activation, invasion metastasis highlighted, ERK/MAPK matrix degradation angiogenesis emphasised.

Language: Английский

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Compromised MAPK signaling in human diseases: an update

Archives of Toxicology, Journal Year: 2015, Volume and Issue: 89(6), P. 867 - 882

Published: Feb. 17, 2015

Language: Английский

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The role of interleukin-1 in general pathology

Inflammation and Regeneration, Journal Year: 2019, Volume and Issue: 39(1)

Published: June 5, 2019

Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances play important role in health disease. In this decade, interleukin-1 family members been expanding evidence accumulating that highlights the importance of linking innate immunity with a broad spectrum diseases beyond diseases. review, we look back on definition "inflammation" traditional general pathology discuss new insights into view its history molecular bases diseases, as well current progress therapeutics.

Language: Английский

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Diversity and versatility of p38 kinase signalling in health and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(5), P. 346 - 366

Published: Jan. 27, 2021

Language: Английский

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Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: April 19, 2018

Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor 1 (TNFR1) and 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 ubiquitously expressed on almost all cells, while TNFR2 exhibits limited expression, predominantly regulatory T cells (Tregs). In addition, the signaling pathway by sTNF via mainly triggers pro-inflammatory pathways, mTNF binding to usually initiates immune modulation tissue regeneration. TNFα plays critical role in upregulation or downregulation of Treg activity. Deficiency significant various autoimmune diseases. An ideal therapeutic strategy for diseases would be selectively block sTNF/TNFR1 signal administration inhibitors, using antagonists keeping intact. Another promising rely agonists could drive expansion Tregs promote Design these strategies targeting pathways holds promise treatment diverse inflammatory degenerative

Language: Английский

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JNK-signaling: A multiplexing hub in programmed cell death

Genes & Cancer, Journal Year: 2017, Volume and Issue: 8(9-10), P. 682 - 694

Published: Nov. 2, 2017

Jun N-terminal kinases or JNKs have been shown to be involved in a wide array of signaling events underlying tumorigenesis and tumor progression.Through its interaction with diverse set proteins adaptors, regulate cell proliferation, invasive migration, therapy resistance, programmed death.JNKs play role apoptotic as well non-apoptotic death mechanisms including those necroptosis, ferroptosis, pyroptosis, autophagy.Most the tumorigenic regulatory functions can related their ability module via these mechanisms.JNKs stimulate inhibit context-dependent manner by stimulating expression specific genes modulating activities pro-and antiapoptotic through distinct phosphorylation events.This review summarizes our current understanding JNK impact on cancer growth, progression, therapy.

Language: Английский

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Metabolic Messengers: tumour necrosis factor

Nature Metabolism, Journal Year: 2021, Volume and Issue: 3(10), P. 1302 - 1312

Published: Oct. 14, 2021

Language: Английский

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IL-1β and the Intestinal Epithelial Tight Junction Barrier

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 25, 2021

The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from lumen into tissue and systemic circulation. A defective TJ has been implicated as an important pathogenic factor in inflammatory diseases gut including Crohn’s disease, ulcerative colitis, necrotizing enterocolitis, celiac disease. Previous studies have shown that pro-inflammatory cytokines, which are produced during inflammation, interleukin-1β (IL-1β), tumor necrosis factor-α, interferon-γ, barrier-modulating actions. Recent IL-1β-induced increase permeability is contributing inflammation. mediated by regulatory signaling pathways activation nuclear transcription factor-κB, myosin light chain kinase gene activation, post-transcriptional occludin modulation microRNA contributes to process. In this review, role IL-1β on barrier, intracellular mechanisms mediate permeability, potential therapeutic targeting discussed.

Language: Английский

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Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities

Progress in Retinal and Eye Research, Journal Year: 2020, Volume and Issue: 82, P. 100906 - 100906

Published: Oct. 3, 2020

Language: Английский

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