Fluorescent Probes as a Tool in Diagnostic and Drug Delivery Systems

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(3), P. 381 - 381

Published: March 1, 2023

Over the last few years, development of fluorescent probes has received considerable attention. Fluorescence signaling allows noninvasive and harmless real-time imaging with great spectral resolution in living objects, which is extremely useful for modern biomedical applications. This review presents basic photophysical principles strategies rational design as visualization agents medical diagnosis drug delivery systems. Common phenomena, such Intramolecular Charge Transfer (ICT), Twisted (TICT), Photoinduced Electron (PET), Excited-State Proton (ESIPT), Fluorescent Resonance Energy (FRET), Aggregation-Induced Emission (AIE), are described platforms fluorescence sensing vivo vitro. The presented examples focused on pH, biologically important cations anions, reactive oxygen species (ROS), viscosity, biomolecules, enzymes that find application diagnostic purposes. general regarding molecular logic devices fluorescence-drug conjugates theranostic systems discussed. work could be help researchers working field compounds, gates, delivery.

Language: Английский

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Advanced Techniques for Detecting Protein Misfolding and Aggregation in Cellular Environments

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(21), P. 12254 - 12311

Published: Oct. 24, 2023

Protein misfolding and aggregation, a key contributor to the progression of numerous neurodegenerative diseases, results in functional deficiencies creation harmful intermediates. Detailed visualization this process is paramount importance for improving our understanding disease mechanisms development potential therapeutic strategies. While vitro studies using purified proteins have been instrumental delivering significant insights into protein misfolding, behavior these complex milieu living cells often diverges significantly from such simplified environments. Biomedical imaging performed cell provides cellular-level information with high physiological pathological relevance, surpassing depth attainable through methods. This review highlights variety methodologies used scrutinize within biological systems. includes optical-based methods, strategies leaning on mass spectrometry, in-cell nuclear magnetic resonance, cryo-electron microscopy. Recent advancements techniques notably deepened processes features resulting misfolded species cells. The fields promises catalyze further breakthroughs comprehension interventions.

Language: Английский

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A closer look at amyloid ligands, and what they tell us about protein aggregates

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 53(3), P. 1354 - 1374

Published: Dec. 20, 2023

A database of over 2000 different ligands that bind amyloid fibrils (Aβ, tau, or αSyn) has been compiled and used to investigate the factors influence binding affinity selectivity.

Language: Английский

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Synthesis of a novel N-fused ring based organic molecule probe and its detection of iron

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 163, P. 112381 - 112381

Published: April 2, 2024

Language: Английский

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Water-Soluble Small Organic Fluorophores for Oncological Theragnostic Applications: Progress and Development

Topics in Current Chemistry, Journal Year: 2024, Volume and Issue: 382(2)

Published: April 26, 2024

Language: Английский

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Design strategies for organelle-selective fluorescent probes: where to start?

RSC Advances, Journal Year: 2025, Volume and Issue: 15(3), P. 2115 - 2131

Published: Jan. 1, 2025

Advancing the development of organelle-targeted small fluorescent probes by highlighting key design strategies to reveal cellular dynamics and address persistent challenges in probe design.

Language: Английский

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Simple excited state intramolecular proton transfer (ESIPT) based probe for pH and selective detection of copper(II) ion in aqueous alkaline environment: Sensitivity, selectivity and logic behavior

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2023, Volume and Issue: 446, P. 115176 - 115176

Published: Sept. 19, 2023

Language: Английский

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Design and Synthesis of a Novel ICT Bichromophoric pH Sensing System Based on 1,8-Naphthalimide Fluorophores as a Two-Input Logic Gate and Its Antibacterial Evaluation

Molecules, Journal Year: 2023, Volume and Issue: 28(8), P. 3631 - 3631

Published: April 21, 2023

The synthesis, sensor activity, and logic behavior of a novel 4-iminoamido-1,8-naphthalimide bichromophoric system based on "fluorophore-receptor" architecture with ICT chemosensing properties is reported. synthesized compound showed good colorimetric fluorescence signaling as function pH proved itself promising probe for the rapid detection in an aqueous solution base vapors solid state. dyad able to work two-input gate chemical inputs H+ (Input 1) HO- 2) executing INHIBIT gate. corresponding intermediates demonstrated antibacterial activity toward Gram (+) (-) bacteria when compared Gentamycin standard.

Language: Английский

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Aggregation-induced emission(AIE)for Next-Generation Biosensing and Imaging : A review

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 271, P. 117067 - 117067

Published: Dec. 14, 2024

Language: Английский

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Hydroxyethyl-Modified Cycloheptatriene-BODIPY Derivatives as Specific Tau Imaging Probes

ACS Medicinal Chemistry Letters, Journal Year: 2023, Volume and Issue: 14(8), P. 1108 - 1112

Published: July 11, 2023

Near-infrared fluorescence (NIRF) imaging as an exquisite sensitive, high spatial-resolution, and real-time tool plays important role in visualizing pathologies the brain. In this study, we designed synthesized a series of NIR probes hydroxyethyl cycloheptatriene-BODIPY derivatives that have demonstrated strong binding specificity to native neurofibrillary tangles (NFTs) Alzheimer's disease (AD) brain sections. The improved hydrophilicity TNIR7-9 TNIR7-11 resulted faster clearance rates from healthy brains (4.2 10.9, respectively) compared previously reported compounds. Furthermore, TNIR7-13, which features fluorinated modification, exhibited affinity Tau aggregates (Kd = 11.8 nM) held promise for future PET studies.

Language: Английский

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