Transcriptional networks controlling stromal cell differentiation DOI
Alexander Rauch, Susanne Mandrup

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(7), P. 465 - 482

Published: April 9, 2021

Language: Английский

Single-Cell Analysis of the Muscle Stem Cell Hierarchy Identifies Heterotypic Communication Signals Involved in Skeletal Muscle Regeneration DOI Creative Commons
Andrea J. De Micheli, Emily J. Laurilliard,

Charles L. Heinke

et al.

Cell Reports, Journal Year: 2020, Volume and Issue: 30(10), P. 3583 - 3595.e5

Published: March 1, 2020

Language: Английский

Citations

314
Control of satellite cell function in muscle regeneration and its disruption in ageing DOI
Pedro Sousa‐Victor, Laura García‐Prat, Pura Muñoz‐Cánoves

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 23(3), P. 204 - 226

Published: Oct. 18, 2021

Language: Английский

Citations

283
Perspectives on skeletal muscle stem cells DOI Creative Commons
Frédéric Relaix, Maximilien Bencze, Matthew J. Borok

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 29, 2021

Abstract Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident stem cells (MuSCs). In this review, we introduce recently developed technologies and the mechanistic insights they provide understanding of MuSC biology, including re-definition quiescence G alert states. Additionally, present recent studies that link function with cellular heterogeneity, highlighting complex regulation self-renewal in regeneration, disorders aging. Finally, discuss metabolism role, as well multifaceted MuSCs by their niche. The presented conceptual advances field impact on our general therapeutic use regenerative medicine.

Language: Английский

Citations

271
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors DOI Creative Commons

Laura Lukjanenko,

Sonia Karaz,

Pascal Stuelsatz

et al.

Cell stem cell, Journal Year: 2019, Volume and Issue: 24(3), P. 433 - 446.e7

Published: Jan. 27, 2019

Language: Английский

Citations

269
Adult stem cells at work: regenerating skeletal muscle DOI Creative Commons

Manuel Schmidt,

Svenja C. Schüler,

Sören S. Hüttner

et al.

Cellular and Molecular Life Sciences, Journal Year: 2019, Volume and Issue: 76(13), P. 2559 - 2570

Published: April 11, 2019

Skeletal muscle regeneration is a finely tuned process involving the activation of various cellular and molecular processes. Satellite cells, stem cells skeletal muscle, are indispensable for regeneration. Their functionality critically modulated by intrinsic signaling pathways as well interactions with cell niche. Here, we discuss properties satellite including heterogeneity regarding gene expression and/or their phenotypic traits contribution to We also summarize specific emphasis on pathways, cytoskeletal rearrangements, importance miRNAs, non-satellite such immune fibro-adipogenic progenitor PW1-positive/Pax7-negative interstitial cells.

Language: Английский

Citations

259
Ageing and rejuvenation of tissue stem cells and their niches DOI
Anne Brunet, Margaret A. Goodell, Thomas A. Rando

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 24(1), P. 45 - 62

Published: July 20, 2022

Language: Английский

Citations

218
Orienting Muscle Stem Cells for Regeneration in Homeostasis, Aging, and Disease DOI Creative Commons
Peter Feige, Caroline Brun, Morten Ritso

et al.

Cell stem cell, Journal Year: 2018, Volume and Issue: 23(5), P. 653 - 664

Published: Nov. 1, 2018

Language: Английский

Citations

205
Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

203
Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells DOI Creative Commons

Irene Hernando-Herraez,

Brendan Evano, Thomas M. Stubbs

et al.

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Sept. 25, 2019

Abstract Age-related tissue alterations have been associated with a decline in stem cell number and function. Although increased cell-to-cell variability transcription or epigenetic marks has proposed to be major hallmark of ageing, little is known about the molecular diversity cells during ageing. Here we present single multi-omics study mouse muscle cells, combining single-cell transcriptome DNA methylome profiling. Aged show global increase uncoordinated transcriptional heterogeneity biased towards genes regulating cell-niche interactions. We find context-dependent methylation aged cells. Importantly, promoters are they drive. These results indicate that drift, by accumulation stochastic changes promoters, degradation coherent networks Furthermore, our observations also shed light on mechanisms underlying clock.

Language: Английский

Citations

201
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age DOI
Laura García‐Prat, Eusebio Perdiguero, Sonia Alonso‐Martin

et al.

Nature Cell Biology, Journal Year: 2020, Volume and Issue: 22(11), P. 1307 - 1318

Published: Oct. 26, 2020

Language: Английский

Citations

132