Journal of Biomaterials Science Polymer Edition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 38
Published: April 28, 2025
Polyamidoamine
dendrimer
(PAMAM)
are
effective
carriers
that
transport
diagnostic
imaging
reagents
and
drugs
to
the
tumor
site.
Their
excellent
bio-compatibility
bio-degradability
reduce
damage
healthy
tissues,
resulting
in
improved
treatment
efficacy.
Dendrimer
molecules
particularly
useful
targeted
drug
delivery
within
malignant
cells.
This
article
reviews
recent
progress
of
PAMAM
treating
breast
cancer,
lung
hepatocellular
colorectal
gastric
prostate
glioblastoma.
review
aims
provide
new
feasible
ideas
for
cancer
diagnosis
while
also
serving
as
a
significant
reference
point
personalized
therapy
based
on
materials.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Feb. 25, 2025
Cancer
stem
cells
(CSCs)
are
central
to
tumor
progression,
metastasis,
immune
evasion,
and
therapeutic
resistance.
Characterized
by
remarkable
self-renewal
adaptability,
CSCs
can
transition
dynamically
between
stem-like
differentiated
states
in
response
external
stimuli,
a
process
termed
"CSC
plasticity."
This
adaptability
underpins
their
resilience
therapies,
including
checkpoint
inhibitors
adoptive
cell
therapies
(ACT).
Beyond
intrinsic
properties,
reside
specialized
microenvironment—the
CSC
niche—which
provides
immune-privileged
protection,
sustains
stemness,
fosters
suppression.
review
highlights
the
critical
role
of
niche
driving
immunotherapy
resistance,
emphasizing
need
for
integrative
approaches
overcome
these
challenges.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2025,
Volume and Issue:
44(1)
Published: March 3, 2025
Abstract
The
chemotherapy
resistance
is
an
awkward
challenge
in
management
of
bladder
cancer
(BC).
Cancer
organoid
model
effective
preclinical
tumor
that
could
faithfully
represent
clinical
manifestations
and
simulate
the
biological
processes
chemoresistance.
Recent
studies
have
revealed
stem
cells
(CSCs)
play
a
significant
role
development
chemoresistance
cancer.
Exosomes
act
as
essential
intercellular
messengers
participate
controlling
conversion
distinct
cell
characteristics,
including
However,
exosome-transmitted
lncRNAs
has
rarely
been
reported.
In
this
study,
models
were
developed
from
urothelial
carcinomas
to
explore
pathophysiology
mechanism
BC
chemoresistance,
RNA-seq
was
performed
screen
for
involved
BC.
We
found
enriches
stem-like
BC,
upregulation
Lung
Associated
Transcript
1
(LUCAT1)
occurs
chemotherapy-resistant
organoids
correlated
with
response.
Further
experimental
results
demonstrated
LUCAT1
promotes
by
enhancing
stemness
phenotype
vivo
vitro.
Moreover,
exosomes
derived
can
enhance
delivering
LUCAT1.
Mechanistically,
significantly
mRNA
stability
HMGA1
via
binding
IGF2BP2
m6A-dependent
manner.
study
demonstrates
important
potential
function
both
diagnostic
biomarker
therapeutic
target
Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 22, 2024
Abstract
Cancer
stem
cells
(CSCs)
represent
a
small
yet
pivotal
subset
of
tumor
endowed
with
self-renewal
capabilities.
These
are
intricately
linked
to
progression
and
central
drug
resistance,
metastasis,
recurrence.
The
microenvironment
(TME)
encompasses
the
cancer
their
surrounding
milieu,
including
immune
inflammatory
cells,
cancer-associated
fibroblasts,
adjacent
stromal
tissues,
vasculature,
variety
cytokines
chemokines.
Within
TME,
such
as
endothelial
adipocytes,
fibroblasts
release
growth
factors,
cytokines,
chemokines,
exosomes,
which
can
either
sustain
or
disrupt
CSCs,
thereby
influencing
progression.
Conversely,
CSCs
also
secrete
affecting
various
components
TME.
Exosomes,
extracellular
vesicles
(EVs),
carry
complex
cargo
nucleic
acids,
proteins,
lipids,
playing
crucial
role
in
communication
between
This
review
primarily
focuses
on
impact
exosomes
secreted
by
(CSC-exo)
progression,
roles
maintaining
stemness,
promoting
angiogenesis,
facilitating
inducing
suppression,
contributing
resistance.
Additionally,
we
discuss
how
different
within
TME
affect
CSCs.
Finally,
explore
potential
utilizing
mitigate
detrimental
effects
target
eliminate
them.
A
thorough
understanding
exosome-mediated
crosstalk
could
provide
valuable
insights
for
developing
targeted
therapies
against
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Dedifferentiation
programs
are
commonly
enacted
during
breast
cancer
progression
to
enhance
tumor
cell
fitness.
Increased
cellular
plasticity
within
the
neoplastic
compartment
of
tumors
correlates
with
disease
aggressiveness,
often
culminating
in
greater
resistance
cytotoxic
therapies
or
augmented
ability
metastasize
distant
organs.
Here
we
report
that
subpopulations
dedifferentiated
epithelial
cells
express
canonical
leukocyte
surface
receptor
proteins
and
have
thus
named
this
program
"immune
mimicry."
We
document
engaging
immune
mimicry
public
human
single-cell
RNA-seq
datasets,
histopathological
specimens,
lines,
as
well
murine
transgenic
line-derived
mammary
models.
Immune-mimicked
harbor
hallmarks
dedifferentiation
appear
enriched
treatment-resistant
high-grade
tumors.
corroborated
these
observations
aggressive
lines
where
growth-arresting
chemotherapies
drove
toward
mimicry.
Moreover,
subsequent
proof-of-concept
studies,
demonstrate
expression
CD69
activation
marker
by
confers
a
proliferative
advantage
facilitates
early
growth.
conclude
upregulate
receptors
potentiate
malignancy.
Moving
forward,
should
be
evaluated
for
prognostic
utility
determine
its
stratification
potential
patients
increased
risks
recurrence,
metastasis,
therapeutic
resistance.
