With
the
quickening
of
life
rhythm,
incidence
rate
constipation
gradually
increased
and
attracted
more
attention.
In
this
study,
wheat
germ,
a
by-product
wheat,
was
used
as
raw
material
to
prepare
germ
polysaccharides
by
ultrahigh
pressure
extraction
method
(WGP),
which
added
value
yield
WGP.
The
alleviating
effect
WGP
its
mechanism
on
diphenoxylate-induced
were
studied
in
mice.
Results
showed
that
could
regulate
defecation
function,
improve
intestinal
transit
ratio,
protect
small
villi
colonic
mucosa
dose-dependently.
Meanwhile,
level
serum
gastrointestinal
regulatory-related
peptides
increase
content
short-chain
fatty
acids
(SCFAs)
constipated
Principal
co-ordinates
analysis
(PcoA)
revealed
alter
gut
microbiota
composition
mice
closer
healthy
heatmap
spearman
correlation
lot
associated
with
constipation.
summary,
effectively
alleviate
enhancing
motility,
regulating
regulatory
peptides,
increasing
SCFAs,
altering
microbiota,
etc.
This
study
provide
theoretical
support
for
thought
high
value-added
utilization
wheat.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: Oct. 5, 2023
The
gut
microbiota
is
a
rich
and
dynamic
ecosystem
that
actively
interacts
with
the
human
body,
playing
significant
role
in
state
of
health
disease
host.
Diet,
exercise,
mental
health,
other
factors
have
exhibited
ability
to
influence
bacterial
composition,
leading
changes
can
prevent
improve,
or
favor
worsen,
both
intestinal
extra-intestinal
conditions.
Altered
microbial
states,
‘dysbiosis’,
associated
conditions
diseases
are
often
characterized
by
shifts
abundance
diversity,
including
an
impaired
Firmicutes
Bacteroidetes
ratio.
By
understanding
effect
lifestyle
on
microbiota,
personalized
advice
be
generated
suit
each
individual
profile
foster
adoption
ameliorate
dysbiosis.
delivery
effective
reliable
advice,
however,
depends
not
only
available
research
current
topic,
but
also
methods
used
assess
individuals
discover
associations,
which
introduce
bias
at
multiple
stages.
aim
this
review
summarize
how
variability
defined
what
choices
shown
association
composition.
Furthermore,
popular
investigate
outlined,
focus
possible
caused
lack
use
standardized
methods.
Finally,
overview
based
testing
presented,
underlining
its
power
limitations.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: July 29, 2024
Human
exposure
to
heavy
metals,
which
encompasses
both
essential
and
toxic
varieties,
is
widespread.
The
intestine
functions
as
a
critical
organ
for
absorption
metabolism
of
metals.
Gut
microbiota
plays
crucial
role
in
metal
absorption,
metabolism,
related
processes.
Toxic
metals
(THMs),
such
arsenic
(As),
mercury
(Hg),
lead
(Pb),
cadmium
(Cd),
can
cause
damage
multiple
organs
even
at
low
levels
exposure,
it
emphasize
their
potential
high
toxicity.
Nevertheless,
certain
trace
elements,
including
iron
(Fe),
copper
(Cu),
manganese
(Mn),
play
vital
roles
the
biochemical
physiological
organisms
concentrations
but
exert
effects
on
gut
higher
levels.
Some
potentially
micronutrients,
chromium
(Cr),
silicon
(Si),
nickel
(Ni),
were
considered
be
intermediate
terms
essentiality
toxicity,
had
different
metabolites.
Bidirectional
relationships
between
have
been
found.
Heavy
disrupts
influences
its
functions,
contributing
metabolic
other
disorders.
Furthermore,
by
serving
physical
barrier
against
modulating
pH,
oxidative
balance,
detoxification
enzymes
or
proteins
involved
metabolism.
interactions
might
positive
negative
according
valence
states,
concentrations,
forms
same
metal.
This
paper
reviews
10
common
with
health
implications.
collated
information
could
provide
novel
insights
into
disruption
intestinal
caused
factor
human
diseases.
Toxics,
Journal Year:
2022,
Volume and Issue:
10(12), P. 744 - 744
Published: Nov. 30, 2022
Arsenic
(As)
is
a
poisonous
metalloid
that
toxic
to
both
humans
and
animals.
Drinking
water
contamination
has
been
linked
the
development
of
cancer
(skin,
lung,
urinary
bladder,
liver),
as
well
other
disorders
such
diabetes
cardiovascular,
gastrointestinal,
neurological,
developmental
damage.
According
epidemiological
studies,
As
contributes
male
infertility,
sexual
dysfunction,
poor
sperm
quality,
consequences
low
birth
weight,
spontaneous
abortion,
small
for
gestational
age
(SGA).
exposure
negatively
affected
reproductive
systems
by
lowering
testicular
accessory
organ
weights,
counts,
increasing
abnormalities
causing
apoptotic
cell
death
in
Leydig
Sertoli
cells,
which
resulted
decreased
testosterone
synthesis.
Furthermore,
during
toxicity,
several
molecular
signalling
pathways,
apoptosis,
inflammation,
autophagy
are
involved.
Phytonutrient
intervention
arsenic-induced
toxicity
various
species
received
lot
attention
over
years.
The
current
review
provides
an
in-depth
summary
available
literature
on
therapeutic
approaches
future
directions.
