Natural Product Communications,
Journal Year:
2024,
Volume and Issue:
19(9)
Published: Sept. 1, 2024
Objective:
Buyang-Huanwu
Decoction
is
often
used
as
an
adjuvant
therapy
for
ischemic
stroke
in
clinical
practice.
At
the
same
time,
various
laboratories
have
found
that
it
has
potential
to
treat
heart
failure,
lower
extremity
varicose
veins,
pulmonary
hypertension,
fibrosis,
and
hyperlipidemia.
Previous
studies
our
laboratory
different
concentrations
of
ethanol
were
separate
polar
components
decoction,
therapeutic
effects
each
group
on
fibrosis
hyperlipidemia
different.
Therefore,
we
analyzed
explored
Buyang
Huanwu
decoction
its
products.
Methods:
The
isolated
obtained
by
treatment
with
absolute
ethanol,
30%
(v/v),
50%
75%
90%
(v/v)
UPLC-MS.
Results:
separation
method
could
well
Decoction,
simply
enrich
carbohydrates,
organic
acids,
phenylpropanoid
compounds,
lipids,
nucleotides,
lignans.
Conclusions:
products
treated
potentials.
high
content
eluate
good
osteoarthritis
bone
loss,
while
precipitate
are
more
likely
be
related
glucose
lipid
metabolism
disorders
cardiovascular
diseases.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(3), P. 758 - 758
Published: Jan. 26, 2023
Osteosarcoma
is
a
common
malignancy
of
the
bone.
Due
to
its
high
metastatic
properties,
osteosarcoma
becomes
leading
cause
cancer
death
worldwide.
Ononin
an
isoflavone
glycoside
known
have
various
pharmacological
including
antioxidant
and
anti-inflammatory
activities.
In
present
study,
we
aimed
investigate
efficacy
ononin
on
cell
migration,
invasion,
underlying
mechanisms.
The
in
vitro
anti-tumorigenic
anti-migratory
properties
were
determined
by
MTT,
colony
formation,
migration
MG-63
U2OS
lines.
results
compared
with
standard
chemotherapeutic
drug,
doxorubicin
(DOX),
as
positive
control.
dose-dependent
manners
treatment
increased
expression
apoptosis
inhibition
proliferation
through
EGFR-Erk1/2
signaling
pathways.
Additionally,
significantly
inhibited
invasion
human
cells.
For
consistency,
used
MG-63-xenograft
mice
model
confirm
vivo
inhibiting
protein
expressions
MMP2/9.
According
histological
had
no
adverse
effect
liver
kidney.
Overall,
our
findings
suggested
that
could
be
potentially
effective
agent
against
development
metastasis
osteosarcoma.
Acta Physiologica,
Journal Year:
2024,
Volume and Issue:
240(8)
Published: June 14, 2024
Chemotherapy
is
a
common
and
effective
treatment
for
cancer,
but
these
drugs
are
also
associated
with
significant
side
effects
affecting
patients'
well-being.
One
such
debilitating
effect
mucositis,
characterized
by
inflammation,
ulcerations,
altered
physiological
functions
of
the
gastrointestinal
(GI)
tract's
mucosal
lining.
Understanding
mechanisms
chemotherapy-induced
intestinal
mucositis
(CIM)
crucial
developing
preventive
measures
supportive
care.
Chemotherapeutics
not
only
target
cancer
cells
rapidly
dividing
in
GI
tract.
These
disrupt
endoplasmic
reticulum
(ER)
homeostasis,
leading
to
ER-stress
activation
unfolded
protein
response
(UPR)
various
epithelial
cell
types.
The
UPR
triggers
signaling
pathways
that
exacerbate
tissue
inflammation
damage,
influence
differentiation
fate
cells,
compromise
integrity
barrier.
factors
contribute
significantly
development
progression.
In
this
review,
we
aim
give
an
in-depth
overview
role
its
impact
on
function.
This
will
provide
valuable
insights
into
underlying
highlighting
potential
therapeutic
interventions
could
improve
treatment-outcomes
quality
life
patients.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 17
Published: Dec. 27, 2022
Lung
cancer
is
a
leading
global
cause
of
cancer-related
death
in
both
males
and
females.
Non-small-cell
lung
(NSCLC)
the
most
commonly
diagnosed
type
that
can
be
difficult
to
control
with
conventional
chemotherapeutic
surgical
approaches
resulting
poor
prognosis.
Paclitaxel
(PTX)
used
drug
for
NSCLC,
which
tissue
injury
healthy
cells
affect
quality
life
patients
cancer.
In
order
treat
alternative
medications
minimal
or
no
side
effects
are
highly
needed.
Ononin
an
isoflavone
glycoside
extracted
from
Astragali
Radix
(AR)
has
various
pharmacological
activities.
Therefore,
this
study
investigated
whether
ononin
inhibits
NSCLC
progression
promotes
apoptosis
synergistically
PTX
vitro
vivo.
Antitumorigenic
properties
were
determined
by
MTT
assay,
colony
formation
migratory
capacity,
apoptotic
marker
expression
A549
HCC827
cells.
The
combination
increased
markers
ROS
generation
inhibited
cell
proliferation
through
PI3K/Akt/mTOR
signaling
pathways.
Furthermore,
prevented
translocation
NF-κB
cytosol
nucleus.
Also,
we
xenograft
mice
model
confirm
vivo
antitumorigenic
efficacies
reduction
CD34
Ki67
expressions.
Based
on
histological
analysis,
cotreatment
reduced
PTX-induced
liver
kidney
damage.
Overall,
our
findings
suggested
therapeutic
index
PTX-based
chemotherapy
could
improved
reducing
toxicity
increasing
antitumor
capabilities
when
combined
ononin.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 12, 2024
As
a
chemotherapy
agent,
doxorubicin
is
used
to
combat
cancer.
However,
cardiotoxicity
has
limited
its
use.
The
existing
strategies
fail
eliminate
doxorubicin-induced
cardiotoxicity,
and
an
in-depth
exploration
of
pathogenesis
in
urgent
need
address
the
issue.
Endoplasmic
reticulum
stress
(ERS)
occurs
when
Reticulum
(ER)
dysfunction
results
accumulation
unfolded
or
misfolded
proteins.
Adaptive
ERS
helps
regulate
protein
synthesis
maintain
cellular
homeostasis,
while
prolonged
stimulation
may
induce
cell
apoptosis,
leading
damage
tissue
organs.
Numerous
studies
on
strongly
link
excessive
activation
mechanisms
including
oxidative
stress,
calcium
imbalance,
autophagy,
ubiquitination,
apoptosis.
researchers
also
found
several
clinical
drugs,
chemical
compounds,
phytochemicals,
miRNAs
inhibited
by
targeting
ERS.
present
review
aims
outline
interactions
between
other
summarize
ERS’s
role
this
type
cardiotoxicity.
Additionally,
enumerates
for
considering
therapeutic
regimens
that
