A wearable sensor based on multifunctional conductive hydrogel for simultaneous accurate pH and tyrosine monitoring in sweat

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 234, P. 115360 - 115360

Published: April 28, 2023

Language: Английский

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Microneedle-based biosensing

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(1), P. 64 - 81

Published: Sept. 26, 2023

Language: Английский

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Minimally invasive electrochemical continuous glucose monitoring sensors: Recent progress and perspective

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 225, P. 115103 - 115103

Published: Jan. 25, 2023

Language: Английский

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Artificial intelligence biosensors for continuous glucose monitoring

Interdisciplinary materials, Journal Year: 2023, Volume and Issue: 2(2), P. 290 - 307

Published: Feb. 9, 2023

Abstract Artificial intelligence (AI) algorithms in combination with continuous monitoring technologies have the potential to revolutionize chronic disease management. The recent innovations both glucose (CGM) and closed‐loop highlight far‐reaching of AI biosensors for individual healthcare. This review summarizes some most advanced progress made CGM biosensing. We will focus on three main applications diabetes management: control algorithms, predictions, calibrations. challenges opportunities individualized proactive medicine also be discussed.

Language: Английский

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Development of Smartphone-Controlled and Microneedle-Based Wearable Continuous Glucose Monitoring System for Home-Care Diabetes Management

ACS Sensors, Journal Year: 2023, Volume and Issue: 8(3), P. 1241 - 1251

Published: Feb. 23, 2023

Continuous glucose monitoring (CGM) can mini-invasively track blood fluctuation and reduce the risk of hyperglycemia hypoglycemia, this is in great demand for diabetes management. However, cost-effective manufacture CGM systems with continuously improved convenience performance still persistent goal. Herein, we developed a smartphone-controlled microneedle (MN)-based wearable system long-term monitoring. The modified sandwich-type enzyme immobilization strategy satisfy clinical requirement interstitial fluid (ISF) 14 days mean absolute relative difference 10.2% cost less than $15, which correlated well commercial glucometer FDA-approved FreeStyle Libre (Abbott Inc., Illinois, USA). self-developed demonstrated to accurately monitor fluctuations provide abundant information. It better find cause individual changes beneficial guide precise control. On whole, intelligently may an alternative solution home-care

Language: Английский

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Wearable, Sensing-Controlled, Ultrasound-Based Microneedle Smart System for Diabetes Management

ACS Sensors, Journal Year: 2023, Volume and Issue: 8(4), P. 1710 - 1722

Published: March 29, 2023

An intelligent closed-loop system that senses glucose and automatically delivers insulin can provide enhanced glycemic control for diabetes management. Here, we report the first time on development of a wearable, sensing-controlled, ultrasound-based microneedle smart Polylactic acid (PLA) hollow microneedles were fabricated by soft lithography maintain excellent mechanical strength stability in biofluids, followed deposition sensing electrodes outer layer. ultrasonic pump was constructed integrating lead zirconate titanate piezoelectric (PZT) ring biocompatible stainless-steel sheet with hundreds tapered holes top inner layer microneedles. Both sensor powered controlled printed circuit board (PCB). When device detects interstitial levels above normal, algorithm triggers to deliver into fluid through channels PLA The ultrasound from cause vaporization subcutaneous tissue fluid, accelerate diffusion rate, improve efficiency treatment utilization. has successfully demonstrated effective diabetic rats. showed high sensitivity 0.212 μA/mM at 0–28 mM detection limit 14 μM, mean absolute relative difference (MARD) 9.96% an average error 1.6 mM. flow rate 120 μL/min, glucose-lowering 4 mM/h. This work may open new paradigm systems management, as well wide range practical applications patients.

Language: Английский

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Wearable flexible microfluidic sensing technologies

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(12), P. 950 - 971

Published: Sept. 8, 2023

Language: Английский

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Paper-Based Sandwich-Structured Wearable Sensor with Sebum Filtering for Continuous Detection of Sweat pH

ACS Sensors, Journal Year: 2023, Volume and Issue: 8(1), P. 176 - 186

Published: Jan. 6, 2023

Wearable sweat sensors, a product of the development flexible electronics and microfluidic technologies, can continuously noninvasively monitor abundant biomarkers in human sweat; however, interferences, such as sebum, reduce sensor reliability accuracy. Herein, for first time, influence sebum on potentiometric response an all-solid-state pH was studied, obtained experimental results show that mixed decrease potential slope its calibration curve. A paper-based sandwich-structured filter proposed based commonly used oil-control sheets. Moreover, hydrophilic properties, microstructure, performance were investigated. The detection comprehensively evaluated terms presence upon addition sebum. Furthermore, anti-interference ability using different analytes under various deformation conditions. On-body trials conducted to verify performance, their showed over 90% sweat, significantly enhancing Additionally, channels could be simply fabricated scissor paper, obviating need complex micromachining processes, photolithography laser engraving. Overall, this work illustrates traditional wearable sensors paves way real-world applications.

Language: Английский

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Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects

Journal of Pharmaceutical Analysis, Journal Year: 2023, Volume and Issue: 13(2), P. 111 - 126

Published: Jan. 6, 2023

Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers may therefore substitute blood in drug analysis. However, current ISF extraction techniques require bulky instruments are both time-consuming complicated, which has inspired the development of viable alternatives such as those relying on skin or tissue puncturing with microneedles. Currently, microneedles widely employed for transdermal delivery have been successfully used by different mechanisms facilitate subsequent The integration sensors enables situ analysis specific compound monitoring, while monitoring functions wearable devices allows real-time dose modification. Herein, we review progress based microneedle-assisted discuss related future opportunities challenges.

Language: Английский

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Microneedle Sensors for Point‐of‐Care Diagnostics

Advanced Science, Journal Year: 2024, Volume and Issue: 11(12)

Published: Jan. 15, 2024

Abstract Point‐of‐care (POC) has the capacity to support low‐cost, accurate and real‐time actionable diagnostic data. Microneedle sensors have received considerable attention as an emerging technique evolve blood‐based diagnostics owing their direct painless access a rich source of biomarkers from interstitial fluid. This review systematically summarizes recent innovations in microneedle with particular focus on utility POC personalized medicine. The integration various sensing techniques, mostly electrochemical optical sensing, been established diverse architectures “lab‐on‐a‐microneedle” platforms. tailored geometries, mechanical flexibility, biocompatibility are constructed variety materials fabrication methods. Microneedles categorized into four types: metals, inorganics, polymers, hydrogels, elaborated state‐of‐the‐art bioengineering strategies for minimally invasive, continuous, multiplexed sensing. employed detect wide range electrolytes, metabolites, polysaccharides, nucleic acids, proteins drugs. Insightful perspectives outlined biofluid, microneedles, biosensors, devices, theragnostic instruments, which depict bright future upcoming intelligent health management.

Language: Английский

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