Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137832 - 137832
Published: April 1, 2025
Language: Английский
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(21), P. 8740 - 8746
Published: May 9, 2024
Pressure and temperature, as common physical parameters, are important for monitoring human health. In contrast, single-mode is prone to causing experimental errors. Herein, we innovatively designed a dual-mode flexible sensing platform based on platinum/zinc-meso-tetrakis(4-carboxyphenyl)porphyrin (Pt/Zn-TCPP) nanozyme the quantitative of carcinoembryonic antigen (CEA) in biological fluids with pressure temperature readouts. The Pt/Zn-TCPP catalytic photothermal efficiencies was synthesized by means integrating photosensitizers into porous materials. system after antigen–antibody reaction recognized using skin-like sensor digital multimeter readout, whereas acquired via photoheat conversion under 808 nm near-infrared (NIR) irradiation portable NIR imaging camera smartphone. Meanwhile, carried out homemade three-dimensional (3D)-printed device. Results revealed that developed immunosensing could exhibit good responses within dynamic range 0.5–100 ng mL–1 CEA detection limits 0.24 0.13 mL–1, respectively. addition, were sensed simultaneously without crosstalk interference. Importantly, can effectively avoid false alarms during measurement, thus providing great potential simple low-cost development point-of-care testing.
Language: Английский
Citations
85
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(33), P. 13663 - 13671
Published: Aug. 10, 2024
Rapid and accurate detection of human epidermal growth factor receptor 2 (HER2) is crucial for the early diagnosis prognosis breast cancer. In this study, we reported an iron-manganese ion N-doped carbon single-atom catalyst (FeMn-NC
Language: Английский
Citations
58
Analytical Chemistry, Journal Year: 2023, Volume and Issue: 96(1), P. 581 - 589
Published: Dec. 27, 2023
Although near-infrared responsive photoelectrochemical (PEC) biosensors have less damage to biological components compared UV–visible light, they still reveal an inferior response due the rapid recombination of photogenerated electron–hole. In this study, a near-infrared-driven PEC biosensor is fabricated for microRNA (miRNA) detection via integrating photoelectricity and pyroelectricity. Upon introduction target miRNA-21, exponential DNA amplifier triggered based on enzyme-assisted strand displacement amplification (SDA), releasing multiple Ag2S reporter probes hybridize with capture immobilized CdS-2-mercaptobenzimidazole (2MBI)-modified photoelectrode. As result, under stimulation NIR, photoelectric conversion NPs generates photocurrents. addition, strong hole acceptor ability MBI, pyroelectric effect CdS-2MBI nanocomposites enhanced, which highly pyroelectro-induced charge separation efficiency induces current benefited from spontaneous polarization caused by temperature variation function nanoheaters. Impressively, has achieved sensitive selective determination miRNA-21 limit as low 54 fM. Overall, NIR-driven effects opens up new horizon bioanalysis early disease diagnosis.
Language: Английский
Citations
52
Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)
Published: June 14, 2024
Abstract In recent decades, research on Extracellular Vesicles (EVs) has gained prominence in the life sciences due to their critical roles both health and disease states, offering promising applications diagnosis, drug delivery, therapy. However, inherent heterogeneity complex origins pose significant challenges preparation, analysis, subsequent clinical application. This review is structured provide an overview of biogenesis, composition, various sources EVs, thereby laying groundwork for a detailed discussion contemporary techniques preparation analysis. Particular focus given state‐of‐the‐art technologies that employ microfluidic non‐microfluidic platforms EV processing. Furthermore, this discourse extends into innovative approaches incorporate artificial intelligence cutting‐edge electrochemical sensors, with particular emphasis single proposes current outlines prospective avenues future research. The objective motivate researchers innovate expand methods analysis fully unlocking biomedical potential.
Language: Английский
Citations
39
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: May 14, 2024
Abstract Electrochemical (EC) analysis has emerged as a high‐sensitivity, reliable, cost‐effective, and rapidly evolving technique that garnered significant attention across diverse domains. Furthermore, EC‐based techniques hold great potential for miniaturization integration. The integration of EC with mode/signal (such light, magnetic, thermal signals, etc.) provides unique opportunities biosensors to acquire more information through single sensing platform. By coupling multiple signals or processing them logically, the detection accuracy can be further improved, probability false positives negatives minimized. In this review, thorough multi‐ sensors in field is conducted, along their various (e.g., fluorescence, photothermal, colorimetry, microfluidic, etc.). aim delve into latest advances, applications, well challenges multi‐mode/signal biosensors, where utilization modalities helps enhance accuracy, sensitivity, selectivity. This review new insight synergistic effects integrating other techniques, aiming shed light on near‐future developments EC‐integrated biosensors.
Language: Английский
Citations
32
Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 151, P. 104636 - 104636
Published: July 11, 2024
Language: Английский
Citations
25
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 13, 2024
Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.
Language: Английский
Citations
19
Journal of Biological Engineering, Journal Year: 2025, Volume and Issue: 19(1)
Published: Feb. 7, 2025
Language: Английский
Citations
2
Biosensors, Journal Year: 2023, Volume and Issue: 13(9), P. 866 - 866
Published: Sept. 1, 2023
Lateral flow immunoassay (LFIA) has found a broad application for testing in point-of-care (POC) settings. LFIA is performed using test strips—fully integrated multimembrane assemblies containing all reagents assay performance. Migration of liquid sample along the strip initiates formation labeled immunocomplexes, which are detected visually or instrumentally. The tradeoff LFIA’s rapidity and user-friendliness its relatively low sensitivity (high limit detection), restricts applicability detecting low-abundant targets. An increase attracted many efforts often considered one primary directions developing immunochemical POC assays. Post-assay enhancements based on chemical reactions facilitate high sensitivity. In this critical review, we explain performance post-assay enhancements, discuss their advantages, limitations, compared detection (LOD) improvements, required time enhancement procedures. We raise concerns about enhanced bottlenecks existing experiments. Finally, suggest experimental workflow step-by-step development validation LFIA. This review summarizes state-of-art with enhancement, offers ways to overcome discusses future outlooks highly sensitive conditions.
Language: Английский
Citations
24
Talanta, Journal Year: 2024, Volume and Issue: 271, P. 125700 - 125700
Published: Jan. 26, 2024
Language: Английский
Citations
15