Engineering extracellular vesicles for targeted therapeutics in cardiovascular disease DOI Creative Commons
Enze Fu, Kai Pan, Zongjin Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 19, 2024

Extracellular vesicles (EVs) are nanosized particles secreted by cells that play crucial roles in intercellular communication, especially the context of cardiovascular diseases (CVDs). These carry complex cargo, including proteins, lipids, and nucleic acids, reflects physiological or pathological state their origin. Multiomics analysis cell-derived EVs has provided valuable insights into molecular mechanisms underlying CVDs identifying specific proteins EV-bound targets involved disease progression. Recent studies have demonstrated engineered EVs, which designed to therapeutic molecules modified enhance targeting capabilities, hold promise for treating CVDs. Analysis EV proteome been instrumental key can be targeted modulated within these vesicles. For example, inflammation, thrombosis, cardiac remodeling identified as potential targets. Furthermore, engineering increase delivery tissues, such myocardium, modulate immunogenicity efficacy is an emerging area research. By leveraging gained from multiomics analyses, researchers developing EV-based therapies selectively target processes CVDs, offering a novel potentially more effective treatment strategy. This review integrates core findings highlights applications.

Language: Английский

The interplay of senescence and MMPs in myocardial infarction: implications for cardiac aging and therapeutics DOI

Ashok Kumar Balaraman,

Abdulmalik Saleh Alfawaz Altamimi, M. Arockia Babu

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 20, 2025

Language: Английский

Citations

1
Cell-cell interactions in the heart: advanced cardiac models and omics technologies DOI Creative Commons

Shuai Tan,

Jingsi Yang,

Shijun Hu

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 12, 2024

A healthy heart comprises various cell types, including cardiomyocytes, endothelial cells, fibroblasts, immune and among others, which work together to maintain optimal cardiac function. These cells engage in complex communication networks, known as cell-cell interactions (CCIs), are essential for homeostasis, structure, efficient However, the context of diseases, undergoes damage, leading alterations cellular composition. Such pathological conditions trigger significant changes CCIs, causing rearrangement transition between types. Studying these can provide valuable insights into biology disease mechanisms, enabling development new therapeutic strategies. While organoids advanced 3D co-culture technologies has revolutionized vitro studies recent advancements single-cell spatial multi-omics researchers with powerful convenient tools investigate CCIs at unprecedented resolution. This article provides a concise overview observed both normal injured heart, an emphasis on cutting-edge methods used study interactions. It highlights such systems, omics technologies, that have enhanced understanding CCIs. Additionally, it summarizes practical applications CCI research advancing cardiovascular therapies, offering potential solutions treating by targeting intercellular communication.

Language: Английский

Citations

4
Exosome: an overview on enhanced biogenesis by small molecules DOI

Amir Bavafa,

Maryam Izadpanahi,

Elham Hosseini

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Language: Английский

Citations

0
Recent Advances in Bioreceptor-based Sensing for Extracellular Vesicle Analysis DOI

Myoung Gyu Kim,

Soo Min Ryu,

Yong Shin

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117432 - 117432

Published: April 1, 2025

Language: Английский

Citations

0
Engineering extracellular vesicles for targeted therapeutics in cardiovascular disease DOI Creative Commons
Enze Fu, Kai Pan, Zongjin Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 19, 2024

Extracellular vesicles (EVs) are nanosized particles secreted by cells that play crucial roles in intercellular communication, especially the context of cardiovascular diseases (CVDs). These carry complex cargo, including proteins, lipids, and nucleic acids, reflects physiological or pathological state their origin. Multiomics analysis cell-derived EVs has provided valuable insights into molecular mechanisms underlying CVDs identifying specific proteins EV-bound targets involved disease progression. Recent studies have demonstrated engineered EVs, which designed to therapeutic molecules modified enhance targeting capabilities, hold promise for treating CVDs. Analysis EV proteome been instrumental key can be targeted modulated within these vesicles. For example, inflammation, thrombosis, cardiac remodeling identified as potential targets. Furthermore, engineering increase delivery tissues, such myocardium, modulate immunogenicity efficacy is an emerging area research. By leveraging gained from multiomics analyses, researchers developing EV-based therapies selectively target processes CVDs, offering a novel potentially more effective treatment strategy. This review integrates core findings highlights applications.

Language: Английский

Citations

1