Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression DOI Creative Commons
Günther Schönrich, Martin Raftery, Yvonne Samstag

et al.

Advances in Biological Regulation, Journal Year: 2020, Volume and Issue: 77, P. 100741 - 100741

Published: July 4, 2020

Pandemic coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome 2 (SARS-CoV-2) and poses an unprecedented challenge to healthcare systems due the lack of a vaccine specific treatment options. Accordingly, there urgent need understand precisely pathogenic mechanisms underlying this multifaceted disease. There increasing evidence that immune system reacts insufficiently SARS-CoV-2 thus contributes organ damage lethality. In review, we suggest overwhelming production reactive oxygen species (ROS) resulting in oxidative stress major cause local or systemic tissue leads COVID-19. It increases formation neutrophil extracellular traps (NETs) suppresses adaptive arm system, i.e. T cells are necessary kill virus-infected cells. This creates vicious cycle prevents response against SARS-CoV-2. The key role pathogenesis COVID-19 implies therapeutic counterbalancing ROS antioxidants such as vitamin C NAC and/or antagonizing mononuclear phagocyte (MPS) granulocytes blocking TNF-α can prevent from becoming severe. Controlled clinical trials preclinical models needed evaluate hypothesis.

Language: Английский

Activation of apoptosis signalling pathways by reactive oxygen species DOI

Maureen Redza-Dutordoir,

Diana A. Averill‐Bates

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2016, Volume and Issue: 1863(12), P. 2977 - 2992

Published: Sept. 17, 2016

Language: Английский

Citations

3115
Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases DOI Creative Commons
Bee Ling Tan, Mohd Esa Norhaizan, Winnie-Pui-Pui Liew

et al.

Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9

Published: Oct. 16, 2018

Aging is the progressive loss of organ and tissue function over time. Growing older positively linked to cognitive biological degeneration such as physical frailty, psychological impairment, decline. Oxidative stress considered an imbalance between pro- antioxidant species, which results in molecular cellular damage. plays a crucial role development age-related diseases. Emerging research evidence has suggested that can control autoxidation by interrupting propagation free radicals or inhibiting formation subsequently reduce oxidative stress, improve immune function, increase healthy longevity. Indeed, oxidation damage highly dependent on inherited acquired defects enzymes involved redox-mediated signaling pathways. Therefore, molecules with activity promote aging counteract worth discuss further. Of particular interest this article, we highlighted mechanisms antioxidants prevention Taken together, better understanding redox modulation inflammation would provide useful approach for potential interventions, promoting

Language: Английский

Citations

983
Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease DOI Creative Commons
Ze Chen, Ruifeng Tian, Zhi‐Gang She

et al.

Free Radical Biology and Medicine, Journal Year: 2020, Volume and Issue: 152, P. 116 - 141

Published: March 8, 2020

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic worldwide and is strongly associated with presence of oxidative stress. Disturbances in lipid metabolism lead to hepatic accumulation, which affects different reactive oxygen species (ROS) generators, including mitochondria, endoplasmic reticulum, NADPH oxidase. Mitochondrial function adapts NAFLD mainly through downregulation electron transport chain (ETC) preserved or enhanced capacity mitochondrial acid oxidation, stimulates ROS overproduction within ETC components upstream cytochrome c However, non-ETC sources ROS, particular, β-oxidation, appear produce more metabolic diseases. Endoplasmic reticulum stress oxidase alterations are also NAFLD, but degree their contribution remains unclear. Increased generation induces changes insulin sensitivity expression activity key enzymes involved metabolism. Moreover, interaction between redox signaling innate immune forms a complex network that regulates inflammatory responses. Based on mechanistic view described above, this review summarizes mechanisms may account for excessive production potential roles drive progression, therapeutic interventions related

Language: Английский

Citations

952
<p>Reactive Oxygen Species: Drivers of Physiological and Pathological Processes</p> DOI Creative Commons

Javier Checa,

Josep M. Aran

Journal of Inflammation Research, Journal Year: 2020, Volume and Issue: Volume 13, P. 1057 - 1073

Published: Dec. 1, 2020

Abstract: Since the Great Oxidation Event, about 2.4 billion years ago, Earth is immersed in an oxidizing atmosphere. Thus, it has been proposed that excess oxygen, originally a waste product of photosynthetic cyanobacteria, induced oxidative stress and production reactive oxygen species (ROS), which have since acted as fundamental drivers biologic evolution eukaryogenesis. Indeed, throughout organism's lifespan, ROS affect directly (as mutagens) or indirectly messengers regulators) all structural functional components cells, many aspects cell biology. Whether left unchecked by protective antioxidant systems, not only cause genomic mutations but also induce irreversible modification proteins (protein oxidation peroxidation), lipids glycans (advanced lipoxidation glycation end products), impairing their function promoting disease death. Conversely, low-level local play important role both redox-signaling molecules wide spectrum pathways involved maintenance cellular homeostasis (MAPK/ERK, PTK/PTP, PI3K-AKT-mTOR), regulating key transcription factors (NFκB/IκB, Nrf2/KEAP1, AP-1, p53, HIF-1). Consequently, can shape variety functions, including proliferation, differentiation, migration apoptosis. In this review, we will give brief overview relevance physiological pathological processes, particularly inflammation aging. In-depth knowledge molecular mechanisms actuation influence under steady-state stressful conditions pave way for development novel therapeutic interventions. This mitigate harmful outcomes onset progression chronic inflammatory age-related diseases. Keywords: species, stress,

Language: Английский

Citations

632
Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment DOI Creative Commons
Ryosuke Kojima, Daniel Bojar, Giorgio Rizzi

et al.

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: April 3, 2018

Exosomes are cell-derived nanovesicles (50-150 nm), which mediate intercellular communication, and candidate therapeutic agents. However, inefficiency of exosomal message transfer, such as mRNA, lack methods to create designer exosomes have hampered their development into interventions. Here, we report a set EXOsomal transfer cells (EXOtic) devices that enable efficient, customizable production in engineered mammalian cells. These genetically encoded exosome producer enhance production, specific mRNA packaging, delivery the cytosol target cells, enabling efficient cell-to-cell communication without need concentrate exosomes. Further, implanted living mice could consistently deliver cargo brain. Therapeutic catalase by attenuated neurotoxicity neuroinflammation vitro vivo models Parkinson's disease, indicating potential usefulness EXOtic for RNA delivery-based applications.

Language: Английский

Citations

600
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion DOI
Nicole E. Scharping, Dayana B. Rivadeneira, Ashley V. Menk

et al.

Nature Immunology, Journal Year: 2021, Volume and Issue: 22(2), P. 205 - 215

Published: Jan. 4, 2021

Language: Английский

Citations

576
Association between dietary inflammatory index and inflammatory markers in the HELENA study DOI
Nitin Shivappa, James R. Hébert, Laura Censi

et al.

Molecular Nutrition & Food Research, Journal Year: 2016, Volume and Issue: 61(6)

Published: Dec. 17, 2016

Previous research has shown that diet is associated with low-grade systemic inflammation among adults. However, no study yet been conducted to explore the association between inflammatory potential of and adolescents whose dietary behavior may be different from

Language: Английский

Citations

498
Oxidative Stress in Cancer Cell Metabolism DOI Creative Commons
Saniya Arfin, Niraj Kumar Jha, Saurabh Kumar Jha

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(5), P. 642 - 642

Published: April 22, 2021

Reactive oxygen species (ROS) are important in regulating normal cellular processes whereas deregulated ROS leads to the development of a diseased state humans including cancers. Several studies have been found be marked with increased production which activates pro-tumorigenic signaling, enhances cell survival and proliferation drives DNA damage genetic instability. However, higher levels promote anti-tumorigenic signaling by initiating oxidative stress-induced tumor death. Tumor cells develop mechanism where they adjust high expressing elevated antioxidant proteins detoxify them while maintaining resistance apoptosis. Therefore, manipulation can potential target for cancer therapies as present an altered redox balance comparison their counterparts. In this review, we aim provide overview generation sources within cells, ROS-associated pathways, regulation defense systems, well effect progression. It will insight into how pro- pathways could manipulated during treatment cancer.

Language: Английский

Citations

456
Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases DOI Open Access
Cinzia Forni, Francesco Facchiano, Manuela Bartoli

et al.

BioMed Research International, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 16

Published: April 7, 2019

Aging is related to a number of functional and morphological changes leading progressive decline the biological functions an organism. Reactive Oxygen Species (ROS), released by several endogenous exogenous processes, may cause important oxidative damage DNA, proteins, lipids, cellular dysfunctions. The imbalance between ROS production antioxidant defenses brings stress conditions and, accumulation ROS, aging-associated diseases. purpose this review provide overview most relevant data reported in literature on natural compounds, mainly phytochemicals, with activity their potential protective effects age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative chronic inflammation, possibly lower side effects, when compared other drugs.

Language: Английский

Citations

446
Bioactive Peptides DOI Creative Commons

Eric Daliri,

Deog H. Oh,

Byong H. Lee

et al.

Foods, Journal Year: 2017, Volume and Issue: 6(5), P. 32 - 32

Published: April 26, 2017

The increased consumer awareness of the health promoting effects functional foods and nutraceuticals is driving force food nutraceutical market. Bioactive peptides are known for their high tissue affinity, specificity efficiency in health. For this reason, search food-derived bioactive has exponentially. Over years, many potential from have been documented; yet, obstacles such as need to establish optimal conditions industrial scale production absence well-designed clinical trials provide robust evidence proving claims continue exist. Other important factors possibility allergenicity, cytotoxicity stability during gastrointestinal digestion would be addressed. This review discusses our current knowledge on peptides, processing methods challenges development.

Language: Английский

Citations

444