Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review DOI Creative Commons
Felipe Tecchio Borsoi,

Iramaia Angélica Neri-Numa,

Williara Queiroz de Oliveira

et al.

Food Chemistry Molecular Sciences, Journal Year: 2022, Volume and Issue: 6, P. 100155 - 100155

Published: Dec. 13, 2022

Chronic Non-Communicable Diseases (NCDs) have been considered a global health problem, characterized as diseases of multiple factors, which are developed throughout life, and regardless genetics risk factor important relevance, the increase in mortality attributed to disease environmental factors lifestyle one leads. Although reactive species (ROS/RNS) necessary for several physiological processes, their overproduction is directly related pathogenesis aggravation NCDs. In contrast, dietary polyphenols widely associated with minimizing oxidative stress inflammation. addition antioxidant power, also drawn attention being able modulate both gene expression modify epigenetic alterations, suggesting an essential involvement prevention and/or development some pathologies. Therefore, this review briefly explained mechanisms NCDs, followed by summary evidence interaction stress, well modulation involved management

Language: Английский

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications DOI Creative Commons
Xinyang Zhong, Xuefeng He, Yaxian Wang

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Nov. 1, 2022

Colorectal cancer (CRC) is the third most common and second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark cancer, Warburg effect promotes metastasis remodels tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation drug resistance. Targeting metabolism would be promising method for treatment CRC. In this review, we summarize information about roles in microenvironment to elucidate mechanisms governing identify novel targets therapy.

Language: Английский

Citations

160
Theranostic Fluorescent Probes DOI Creative Commons
Amit Sharma, Peter Verwilst, Mingle Li

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

Citations

139
Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease DOI Creative Commons

Yuanqiang Ma,

Gyurim Lee,

Suyoung Heo

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 11(1), P. 91 - 91

Published: Dec. 30, 2021

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress induce progression of to NASH stimulating Kupffer cells, hepatic stellate hepatocytes. Therefore, are underway identify role antioxidants in treatment NAFLD. In this review, we have summarized origins reactive oxygen species (ROS) relationship between ROS NAFLD, discussed use as therapeutic agents for

Language: Английский

Citations

135
Bioengineered cerium oxide (CeO2) nanoparticles and their diverse applications: a review DOI
Shreyas Pansambal, Rajeshwari Oza, Seema Borgave

et al.

Applied Nanoscience, Journal Year: 2022, Volume and Issue: 13(9), P. 6067 - 6092

Published: Aug. 25, 2022

Language: Английский

Citations

123
Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases DOI Creative Commons
Giusy Daniela Albano, Rosalia Gagliardo, Angela Marina Montalbano

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2237 - 2237

Published: Nov. 13, 2022

Inflammation of the human lung is mediated in response to different stimuli (e.g., physical, radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental pollutants. They often promote an increase inflammatory activities airways that manifest themselves chronic diseases allergic airway diseases, asthma, bronchitis/chronic obstructive pulmonary disease (COPD) even cancer). Increased levels oxidative stress (OS) reduce antioxidant defenses, affect autophagy/mitophagy processes, regulatory mechanisms cell survival, promoting inflammation lung. In fact, OS potentiate lung, favoring progression diseases. increases production reactive oxygen species (ROS), including superoxide anions (O2-), hydroxyl radicals (OH) hydrogen peroxide (H2O2), by transformation through enzymatic non-enzymatic reactions. this manner, reduces endogenous defenses both nucleated non-nucleated cells. The ROS can derive from exogenous insults (cigarette pollution) sources injury and/or activated structural review, we describe most relevant knowledge concerning functional interrelation between

Language: Английский

Citations

119
Oxidative stress and antioxidants in health and disease DOI Creative Commons
Tuğba Raika Kıran, Önder Otlu, Aysun Bay Karabulut

et al.

Journal of Laboratory Medicine, Journal Year: 2023, Volume and Issue: 47(1), P. 1 - 11

Published: Feb. 1, 2023

Abstract The increase in the formation of reactive oxygen and nitrogen species endogenous or exogenous origin causes oxidative stress due to pro-oxidant antioxidant imbalance that cellular damage metabolism. This can inflammation cells, apoptosis necrosis, DNA base damage, protein cross-links, lipid membrane peroxidation, mitochondrial dysfunction. Antioxidants be described as a system protects biomolecules organism against harmful effects free radicals, reduces repairs done by (ROS) target molecule, this is called defense. It known mechanisms caused ROS resulting from are positively related pathology many diseases such cancer, metabolic syndrome, atherosclerosis, malaria, Alzheimer’s disease, rheumatoid arthritis, neurodegenerative preeclampsia.

Language: Английский

Citations

76
Oxidative cell death in cancer: mechanisms and therapeutic opportunities DOI Creative Commons
Xiaoqin An, Wenfeng Yu, Jinbao Liu

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)

Published: Aug. 1, 2024

Abstract Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated as natural byproducts during cellular processes, including metabolism. Under normal conditions, ROS play crucial roles in diverse functions, cell signaling and immune responses. However, a disturbance the balance between production antioxidant defenses can lead to an excessive buildup, causing oxidative stress. This stress damages essential components, lipids, proteins, DNA, potentially culminating death. form of death take various forms, such ferroptosis, apoptosis, necroptosis, pyroptosis, paraptosis, parthanatos, oxeiptosis, each displaying distinct genetic, biochemical, characteristics. The investigation holds promise for development pharmacological agents that used prevent tumorigenesis or treat established cancer. Specifically, targeting key SLC7A11, GCLC, GPX4, TXN, TXNRD, represents emerging approach inducing cancer cells. review provides comprehensive summary recent progress, opportunities, challenges therapy.

Language: Английский

Citations

75
Altered metabolism in cancer: insights into energy pathways and therapeutic targets DOI Creative Commons
Muhammad Tufail, Canhua Jiang, Ning Li

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 18, 2024

Language: Английский

Citations

71
Hyaluronan and Reactive Oxygen Species Signaling—Novel Cues from the Matrix? DOI Creative Commons
Aikaterini Berdiaki, Monica Neagu,

Ioanna Spyridaki

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 824 - 824

Published: March 28, 2023

Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG) localized to the cell surface and tissue extracellular matrix (ECM). It composed of disaccharides containing glucuronic acid N-acetylglucosamine, synthesized by HA synthase (HAS) enzymes degraded hyaluronidase (HYAL) or reactive oxygen nitrogen species (ROS/RNS) actions. deposited as high molecular weight (HMW) polymer low (LMW) fragments oligosaccharides. affects biological functions interacting with HA-binding proteins (hyaladherins). HMW anti-inflammatory, immunosuppressive, antiangiogenic, whereas LMW has pro-inflammatory, pro-angiogenetic, oncogenic effects. ROS/RNS degrade HA, albeit at enhanced levels during injury inflammatory processes. Thus, degradation endothelial glycocalyx increased ROS challenges vascular integrity can initiate several disease progressions. Conversely, exerts vital role in wound healing through ROS-mediated modifications, which affect innate immune system. The normal turnover protects against rigidification. Insufficient leads rigidity, leading dysfunction. Both endogenous exogenous have scavenging capacity ROS. interactions are more complex than presently perceived present an important research topic.

Language: Английский

Citations

60
Recent advance of herbal medicines in cancer- a molecular approach DOI Creative Commons
Mohammad Ali, Shahid Ud Din Wani, Mohammed Salahuddin

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(2), P. e13684 - e13684

Published: Feb. 1, 2023

Bioactive compounds are crucial for an extensive range of therapeutic uses, and some exhibit anticancer activity. Scientists advocate that phytochemicals modulate autophagy apoptosis, involved in the underlying pathobiology cancer development regulation. The pharmacological aiming autophagy-apoptosis signaling pathway using phytocompounds hence offers auspicious method is complementary to conventional chemotherapy. current review aims explore molecular level autophagic-apoptotic know its implication essential cellular process as a druggable target emergence naturally derived phytocompound-based agents. data were collected from scientific databases such Google search, Web Science, PubMed, Scopus, Medline, Clinical Trials. With broad outlook, we investigated their cutting-edge scientifically revealed and/or searched pharmacologic effects, novel mechanism action, therapy. In this review, evidence focused on pharmacology, specifically caspase, Nrf2, NF-kB, pathway, several mechanisms understand role biology.

Language: Английский

Citations

57