Unveiling the microbial influence: bacteria’s dual role in tumor metastasis DOI Creative Commons

Li-Ying Lin,

Dongyan Zhang

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 14, 2025

As cancer research advances, the intricate relationship between microbiome and is gaining heightened recognition, especially concerning tumor metastasis, where bacterial involvement becomes increasingly complex. This review seeks to systematically examine dual roles of bacteria in metastasis process, encompassing both mechanisms that facilitate inhibitory effects exerted by specific microorganisms. We explore through which influence cell migration inducing chronic inflammation, evading host immune responses, remodeling ECM. Moreover, immunomodulatory potential probiotics genetically engineered offers promising prospects for prevention treatment metastasis. article elucidates complexity emerging frontiers examining clinical significance as biomarkers evaluating antibiotic usage on metastatic process. posit comprehending biological characteristics bacteria, a critical component microenvironment, will offer innovative strategies theoretical foundations treatment. Furthermore, this explores future directions, including application technologies bacteria-based therapeutic strategies, thereby offering valuable perspective development novel anti-cancer approaches.

Language: Английский

Intratumoural microbiota: a new frontier in cancer development and therapy DOI Creative Commons

Yaqi Cao,

Hui Xia,

Xueyun Tan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 10, 2024

Abstract Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of which have been confirmed to be closely related oncogenesis. The concept intratumoural microbiota was subsequently proposed. Microbiota could colonise through mucosal destruction, adjacent tissue migration, hematogenic invasion affect the biological behaviour tumours as an important part microenvironment. Mechanistic demonstrated potentially promote initiation progression by inducing genomic instability mutations, affecting epigenetic modifications, promoting inflammation response, avoiding immune regulating metabolism, activating metastasis. Since more comprehensive profound insights about intratumoral are continuously emerging, new methods for early diagnosis prognostic assessment cancer patients under examination. In addition, interventions based on show great potential open chapter antitumour therapy, especially immunotherapy, although there some inevitable challenges. Here, we aim provide extensive review concept, development history, sources, heterogeneity, carcinogenic mechanisms explore role microorganisms prognosis, discuss current treatment regimens target research prospects limitations this field.

Language: Английский

Citations

74
Tumor microenvironment as a complex milieu driving cancer progression: a mini review DOI Creative Commons
Zhengrui Li, Jing Li,

Xiaolei Bai

et al.

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Language: Английский

Citations

20
Broadening oncological boundaries: the intratumoral microbiota DOI Creative Commons
Ying‐Qi Lu, Han Qiao,

Xi-Rong Tan

et al.

Trends in Microbiology, Journal Year: 2024, Volume and Issue: 32(8), P. 807 - 822

Published: Feb. 3, 2024

The microbiota of solid tumors was identified >100 years ago; however, heterogeneous composition and diversity have been revealed only recently. Growing evidence has suggested that several functional mechanisms the intratumoral affect tumorigenesis progression, suggesting is a promising biomarker for multiple cancers. low biomass poses major challenge to related research, thus necessitating use multiple-modality integrated framework resolve this dilemma. Advanced techniques such as single-cell sequencing provide significant clues, gradual optimization experiments culture-based methods enables deeper investigation underlying involved. In review, we outline current state research on describe challenges comprehensive strategies future research.

Language: Английский

Citations

19
Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer DOI Creative Commons
Shan Liu,

Xingda Zhang,

Wenzheng Wang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 21, 2024

Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth contributes treatment resistance. In primary breast metabolic shifts such as the Warburg effect enhanced lipid synthesis are closely linked chemotherapy failure. Similarly, metastatic lesions often display distinct profiles that not only sustain but also confer resistance targeted therapies immunotherapies. The review emphasizes two major aspects: mechanisms driving in both how unique environments sites further complicate treatment. By targeting vulnerabilities at stages, new strategies could improve efficacy existing provide better outcomes for cancer patients.

Language: Английский

Citations

17
A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study DOI Creative Commons
Barbara Pardini, Giulio Ferrero, Sonia Tarallo

et al.

Gastroenterology, Journal Year: 2023, Volume and Issue: 165(3), P. 582 - 599.e8

Published: May 30, 2023

Background & AimsFecal tests currently used for colorectal cancer (CRC) screening show limited accuracy in detecting early tumors or precancerous lesions. In this respect, we comprehensively evaluated stool microRNA (miRNA) profiles as biomarkers noninvasive CRC diagnosis.MethodsA total of 1273 small RNA sequencing experiments were performed multiple biospecimens. a cross-sectional study, miRNA investigated fecal samples from an Italian and Czech cohort (155 CRCs, 87 adenomas, 96 other intestinal diseases, 141 colonoscopy-negative controls). A predictive signature detection was defined by machine learning strategy tested additional patients 80 healthy volunteers. compared with those 132 tumors/adenomas paired adjacent mucosa, 210 plasma extracellular vesicle samples, 185 immunochemical test leftover samples.ResultsTwenty-five miRNAs showed altered levels the both cohorts (adjusted P < .05). 5-miRNA signature, including miR-149-3p, miR-607-5p, miR-1246, miR-4488, miR-6777-5p, distinguished control individuals (area under curve [AUC], 0.86; 95% confidence interval [CI], 0.79–0.94) validated independent (AUC, 0.96; CI, 0.92–1.00). The classified low-/high-stage advanced adenomas 0.82; 0.71–0.97). Tissue mirrored different gastrointestinal diseases highlighted specifically dysregulated CRC. good correlation collected preservative buffer, their alterations could be detected adenoma patients.ConclusionsOur comprehensive miRNome analysis identified accurately discriminating aimed at improving diagnosis strategies. Fecal diagnosis. samples. Twenty-five patients. Our

Language: Английский

Citations

38
Intratumoral microbiota: implications for cancer onset, progression, and therapy DOI Creative Commons
Jinmei Wu, Pengfei Zhang,

Wuxuan Mei

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 16, 2024

Significant advancements have been made in comprehending the interactions between microbiome and cancer. However, prevailing research predominantly directs its focus toward gut microbiome, affording limited consideration to of intratumoral microbiota tumors. Within tumor microenvironment (TME), associated products wield regulatory influence, directing modulation cancer cell properties impacting immune system functionality. grasp a more profound insight into cancer, further underlying mechanisms is necessary. In this review, we delve intricate associations with specific on elucidating significant contribution onset advancement Notably, provide detailed exploration therapeutic advances facilitated by microbiota, offering insights recent developments burgeoning field.

Language: Английский

Citations

14
Fungi and tumors: The role of fungi in tumorigenesis (Review) DOI Creative Commons

Wenyue Cheng,

Fan Li,

Yunhuan Gao

et al.

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(5)

Published: March 27, 2024

Fungi inhabit different anatomic sites in the human body. Advances omics analyses of host‑microbiome interactions have tremendously improved our understanding effects fungi on health and diseases such as tumors. Due to significant enrichment specific patients with malignant tumors, associations between cancer attracted an increasing attention recent years. Indeed, type‑specific fungal profiles been found tumor tissues. Importantly, also influence tumorigenesis through multiple factors, host immunity bioactive metabolites. Microbiome interactions, factors genetic epigenetic could be involved tissues and/or conversion from a commensal fungus pathogenic fungus. Exploration bacterial microbiome may enable them target for diagnosis treatment. In present review, cancer, mechanisms by which cause were discussed. addition, possible that can lead fungi, well potential therapeutic preventive strategies tumors based intratumoral summarized.

Language: Английский

Citations

11
Unveiling the intratumoral microbiota within cancer landscapes DOI Creative Commons
Shusheng Che, Zhiyong Yan, Yugong Feng

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109893 - 109893

Published: May 3, 2024

Recent advances in cancer research have unveiled a significant yet previously underappreciated aspect of oncology: the presence and role intratumoral microbiota. These microbial residents, encompassing bacteria, fungi, viruses within tumor tissues, been found to exert considerable influence on development, progression, efficacy therapeutic interventions. This review aims synthesize these groundbreaking discoveries, providing an integrated overview identification, characterization, functional roles microbiota biology. We focus elucidating complex interactions between microorganisms microenvironment, highlighting their potential as novel biomarkers targets. The purpose this is offer comprehensive understanding dimension cancer, paving way for innovative approaches diagnosis treatment.

Language: Английский

Citations

9
Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics DOI
Fei Peng, Mengyuan Hu, Zhiyue Su

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)

Published: July 26, 2024

Abstract In recent years, advancements in microbial sequencing technology have sparked an increasing interest the bacteria residing within solid tumors and its distribution functions various tumors. Intratumoral critically modulate tumor oncogenesis development through DNA damage induction, chronic inflammation, epigenetic alterations, metabolic immune regulation, while also influencing cancer treatment efficacy by affecting drug metabolism. response to these discoveries, a variety of anti‐cancer therapies targeting microorganisms emerged. These approaches encompass oncolytic therapy utilizing tumor‐associated bacteria, design biomaterials based on intratumoral use bacterial components for delivery systems, comprehensive strategies aimed at eradication tumor‐promoting bacteria. Herein, this review article summarizes patterns different tumors, examines their impact evaluates current therapeutic centered Furthermore, challenges prospects developing drugs that target communities are explored, promising new directions treatment.

Language: Английский

Citations

9
Exploring the microbiome-gut-testis axis in testicular germ cell tumors DOI Creative Commons
Soňa Čierniková, Aneta Sevcikova, Michal Mego

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 9, 2025

The microbiome-gut-testis axis has emerged as a significant area of interest in understanding testicular cancer, particularly germ cell tumors (TGCTs), which represent the most common malignancy young men. interplay between gut and microbiomes is hypothesized to influence tumorigenesis reproductive health, underscoring complex role microbial ecosystems disease pathology. encompasses interactions microbiome, systemic immune modulation, local microenvironment testis. Dysbiosis or may contribute altered responses, inflammation, hormonal imbalances, potentially playing pathogenesis TGCTs. Concurrently, seminal have been linked variations sperm quality, fertility potential, possibly cancer susceptibility, need for further evaluation. This review explores emerging context highlighting its implications onset, progression, treatment efficacy, toxicity. Identifying potential biomarkers, followed by microbiota modulation restore balanced community, might offer novel supportive strategy improving efficacy refractory TGCT patients while reducing chemotherapy-induced We suggest better association dysregulated environments TGCTs emphasizes pathways microbiome cancer.

Language: Английский

Citations

1