Unveiling the microbial influence: bacteria’s dual role in tumor metastasis DOI Creative Commons

Li-Ying Lin,

Dongyan Zhang

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 14, 2025

As cancer research advances, the intricate relationship between microbiome and is gaining heightened recognition, especially concerning tumor metastasis, where bacterial involvement becomes increasingly complex. This review seeks to systematically examine dual roles of bacteria in metastasis process, encompassing both mechanisms that facilitate inhibitory effects exerted by specific microorganisms. We explore through which influence cell migration inducing chronic inflammation, evading host immune responses, remodeling ECM. Moreover, immunomodulatory potential probiotics genetically engineered offers promising prospects for prevention treatment metastasis. article elucidates complexity emerging frontiers examining clinical significance as biomarkers evaluating antibiotic usage on metastatic process. posit comprehending biological characteristics bacteria, a critical component microenvironment, will offer innovative strategies theoretical foundations treatment. Furthermore, this explores future directions, including application technologies bacteria-based therapeutic strategies, thereby offering valuable perspective development novel anti-cancer approaches.

Language: Английский

The intratumoral microbiota: friend or foe? DOI Open Access
Valentina Ferrari, María Rescigno

Trends in cancer, Journal Year: 2023, Volume and Issue: 9(6), P. 472 - 479

Published: April 13, 2023

Language: Английский

Citations

20
Unveiling intratumoral microbiota: An emerging force for colorectal cancer diagnosis and therapy DOI Creative Commons

Jinjing Zhang,

Penghui Wang, Jiafeng Wang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107185 - 107185

Published: April 12, 2024

Microbes, including bacteria, viruses, fungi, and other eukaryotic organisms, are commonly present in multiple organs of the human body contribute significantly to both physiological pathological processes. Nowadays, development sequencing technology has revealed presence composition intratumoral microbiota, which includes Fusobacterium, Bifidobacteria, Bacteroides, shed light on significant involvement progression colorectal cancer (CRC). Here, we summarized current understanding microbiota CRC outline potential translational clinical applications diagnosis, prevention, treatment CRC. We focused reviewing microbial therapies targeting improve efficacy safety chemotherapy immunotherapy for identify biomarkers diagnosis prognosis Finally, emphasized obstacles solutions translating knowledge into practice.

Language: Английский

Citations

8
A Metal Chelation Therapy to Effectively Eliminate Breast Cancer and Intratumor Bacteria While Suppressing Tumor Metastasis by Copper Depletion and Zinc Ions Surge DOI

Yulin Xie,

Junrong Wang, Chunxia Li

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

Abstract The intratumor microbiota results in the immunosuppressive microenvironment and facilitates tumor growth metastasis. However, developing a synergistic therapy with antitumor, antibacterial, antimetastatic effects faces enormous challenges. Here, we propose an innovative metal chelation to effectively eliminate bacteria suppress Different from traditional that only consumes elements, this not eliminates crucial elements for metabolism but also releases new ions antitumor antibacterial properties. Based on high demand copper breast cancer, prepare fibrous therapeutic nanoagent (Zn‐PEN) by chelating chelator D‐Penicillamine (D‐PEN) Zn 2+ . Firstly, Zn‐PEN achieves dual inhibition of oxidative phosphorylation (OXPHOS) glycolysis cancer through depletion activated cGAS‐STING pathway, thus inducing cell death. Secondly, has capability eradicate Fusobacterium nucleatum ( F. ) thereby mitigating its impact microenvironment. Finally, inhibits metastasis multiple routes, including epithelial‐mesenchymal transition (EMT) process, activation elimination Therefore, verify feasibility mediated 4T1 model infected , providing strategy inhibiting

Language: Английский

Citations

7
Emerging roles of intratumor microbiota in cancer: tumorigenesis and management strategies DOI Creative Commons
Zhuangzhuang Shi, Zhaoming Li,

Mingzhi Zhang

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 11, 2024

Language: Английский

Citations

6
Awareness of intratumoral bacteria and their potential application in cancer treatment DOI Creative Commons
Liang Yin, Qiyan Li, Yulin Liu

et al.

Discover Oncology, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 6, 2023

Abstract Hitherto, the recognition of microbiota role in tumorigenesis and clinical studies mostly focused on intestinal flora. In contrast to gut microbiome, microorganisms resident tumor tissue are close contact with cancer cells therefore have potential similar or even different functional patterns Some investigations shown intratumoral bacteria, which might come from commensal mucosal areas including gastrointestinal tract oral cavity, nearby normal tissues. The existence, origin, interactions bacteria microenvironment all contribute microorganism heterogeneity. Intratumoral a significant formation. They can at genetic level by secreting poisons that directly damage DNA also intimately related immune system response systemic level. an impact chemotherapy immunotherapy cancer. Importantly, various properties such as targeting ease modification make them powerful candidates for precision therapy, combining microbial therapies other is expected improve effectiveness treatment. this review, we mainly described heterogeneity sources overviewed important mechanisms they were involved progression, summarized their value oncology therapy. At last, highlight problems research field, look forward new wave using applications

Language: Английский

Citations

12
Forces at play: exploring factors affecting the cancer metastasis DOI Creative Commons
Farooq Riaz, Jing Zhang, Fan Pan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 1, 2024

Metastatic disease, a leading and lethal indication of deaths associated with tumors, results from the dissemination metastatic tumor cells site primary origin to distant organ. Dispersion during development tumors at organs leads failure comply conventional treatments, ultimately instigating abrupt tissue homeostasis organ failure. Increasing evidence indicates that microenvironment (TME) is crucial factor in cancer progression process secondary sites. TME comprises several factors contributing initiation cascade. Among these, various cell types TME, such as mesenchymal stem (MSCs), lymphatic endothelial (LECs), cancer-associated fibroblasts (CAFs), myeloid-derived suppressor (MDSCs), T cells, tumor-associated macrophages (TAMs), are significant players participating metastasis. Besides, other factors, extracellular matrix (ECM), gut microbiota, circadian rhythm, hypoxia, also shape impact A thorough understanding functions components metastasis necessary discover new therapeutic strategies targeting TME. Therefore, we reviewed these pivotal highlighted background knowledge on how disrupted influence cascade establish premetastatic niche. This review will help researchers identify altered components’ molecular patterns design an optimized, targeted therapy treat solid restrict

Language: Английский

Citations

4
Metabolic heterogeneity in tumor microenvironment – A novel landmark for immunotherapy DOI
Chen Chen, Peng Han, Yanping Qing

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 23(6), P. 103579 - 103579

Published: June 1, 2024

Language: Английский

Citations

4
Research progress on intratumoral microorganisms in renal cancer DOI
Jiankun Zhang,

Keyuan Lou,

Junpeng Chi

et al.

World Journal of Urology, Journal Year: 2025, Volume and Issue: 43(1)

Published: Jan. 15, 2025

Language: Английский

Citations

0
Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy DOI Creative Commons
Kelly Bowlt,

Kevin S. Donnelly,

Yuting Lu

et al.

The Journal of Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Mucosal melanoma is a rare subtype associated with poor prognosis and limited existing therapeutic interventions, in part due to lack of actionable targets translational animal models for preclinical trials. Comprehensive data on this tumour type are scarce, often overlooks the importance anatomical site origin. We evaluated human canine oronasal mucosal (OMM) determine whether common disease could inform equivalent. Using primary OMM cohort treatment‐naive archival tissue, alongside clinicopathological data, we obtained transcriptomic, immunohistochemical, microbiome from both species. defined transcriptomic landscape species linked our findings microbiome, clinical data. Human dog stratified into two distinctive transcriptional groups, which using species‐independent 41‐gene signature. These subgroups termed CTLA4‐high MET‐high indicate patients. To guide decision‐making, developed immunohistochemical diagnostic tools that distinguish between subgroups. found had conserved subtypes biological similarity OMM, significant implications patient classification, treatment, trial design. © 2025 The Author(s). Journal Pathology published by John Wiley & Sons Ltd behalf Pathological Society Great Britain Ireland.

Language: Английский

Citations

0
Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy DOI
Jing Feng, Yanhong Liu, Liming Gong

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110907 - 110907

Published: Feb. 1, 2025

Language: Английский

Citations

0