Crosstalk Between the Intratumoral Microbiota and the Tumor Microenvironment: New Frontiers in Solid Tumor Progression and Treatment DOI Creative Commons
Qing Zhou,

Lijun Zhou,

Xi Chen

et al.

Cancer Reports, Journal Year: 2024, Volume and Issue: 7(11)

Published: Nov. 1, 2024

ABSTRACT Background The microbiota plays a significant role in the tumor microenvironment, and its impact on development treatment outcome cannot be overlooked. Thus, it is essential to comprehend interactions between microenvironment. Recent Findings With advent of next‐generation sequencing, research has advanced significantly recent years. interaction intratumoral microenvironment an emerging area that holds great promise for understanding treating solid progression. This crosstalk complex process involves multitude factors, including immune system, cellular signaling pathways, metabolic processes. origin differs various tumor, quantity diversity also fluctuate within each tumor. Conclusion aim this review provide detailed summary types tumors. will include analysis their origins, differences, how they progression Furthermore, we emphasize potential diagnosis

Language: Английский

Tumor microenvironment as a complex milieu driving cancer progression: a mini review DOI Creative Commons
Zhengrui Li, Jing Li,

Xiaolei Bai

et al.

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Language: Английский

Citations

20
Intratumoral microbiota: implications for cancer onset, progression, and therapy DOI Creative Commons
Jinmei Wu, Pengfei Zhang,

Wuxuan Mei

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 16, 2024

Significant advancements have been made in comprehending the interactions between microbiome and cancer. However, prevailing research predominantly directs its focus toward gut microbiome, affording limited consideration to of intratumoral microbiota tumors. Within tumor microenvironment (TME), associated products wield regulatory influence, directing modulation cancer cell properties impacting immune system functionality. grasp a more profound insight into cancer, further underlying mechanisms is necessary. In this review, we delve intricate associations with specific on elucidating significant contribution onset advancement Notably, provide detailed exploration therapeutic advances facilitated by microbiota, offering insights recent developments burgeoning field.

Language: Английский

Citations

14
Engineering Strategies to Modulate the Gut Microbiome and Immune System DOI
Kai Han,

Jin Xu,

Fang Xie

et al.

The Journal of Immunology, Journal Year: 2024, Volume and Issue: 212(2), P. 208 - 215

Published: Jan. 2, 2024

Abstract The gut microbiota, predominantly residing in the colon, is a complex ecosystem with pivotal role host immune system. Dysbiosis of microbiota has been associated various diseases, and there an urgent need to develop new therapeutics that target microbiome restore functions. This Brief Review discusses emerging therapeutic strategies focus on oral delivery systems for modulating microbiome. These include genetic engineering probiotics, probiotic-biomaterial hybrids, dietary fibers, microbial metabolites, antimicrobial peptides, RNA, antibiotics. Engineered formulations have demonstrated promising outcomes reshaping influencing responses preclinical studies. By leveraging these approaches, interplay between system can be harnessed development novel against cancer, autoimmune disorders, allergies.

Language: Английский

Citations

10
Unveiling the intratumoral microbiota within cancer landscapes DOI Creative Commons
Shusheng Che, Zhiyong Yan, Yugong Feng

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109893 - 109893

Published: May 3, 2024

Recent advances in cancer research have unveiled a significant yet previously underappreciated aspect of oncology: the presence and role intratumoral microbiota. These microbial residents, encompassing bacteria, fungi, viruses within tumor tissues, been found to exert considerable influence on development, progression, efficacy therapeutic interventions. This review aims synthesize these groundbreaking discoveries, providing an integrated overview identification, characterization, functional roles microbiota biology. We focus elucidating complex interactions between microorganisms microenvironment, highlighting their potential as novel biomarkers targets. The purpose this is offer comprehensive understanding dimension cancer, paving way for innovative approaches diagnosis treatment.

Language: Английский

Citations

10
Intratumoral microbiome is associated with gastric cancer prognosis and therapy efficacy DOI Creative Commons
Gangjian Wang, Haojie Wang, Xin Ji

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 30, 2024

The role of the intratumoral microbiome in gastric cancer (GC) has not been comprehensively assessed. Here, we explored relationship between microbial community and GC prognosis therapy efficacy. Several cancer-associated characteristics were identified, including increased α-diversity, differential β-diversity, decreased

Language: Английский

Citations

9
Mast cells: key players in digestive system tumors and their interactions with immune cells DOI Creative Commons

Feihong Shu,

Jie Yu,

Youjia Liu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 15, 2025

Abstract Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health the pathophysiology various illnesses, including allergies, cardiovascular diseases autoimmune diseases. Recent studies tumor-related research have demonstrated that mast exert substantial influence on tumor cell behavior microenvironment, exhibiting pro- anti-tumor effects. Specifically, not only secrete mediators related to pro-tumor function such as trypsin-like enzymes, chymotrypsin, vascular endothelial growth factor histamine, but also progression cystatin C IL-17F. This dual renders them an under-recognized very promising target for immunotherapy. Digestive system tumors, characterized by high morbidity associated mortality rates globally, increasingly recognized healthcare burden. paper examines cell-derived development tumors digestive system. It explores prognostic significance patients with gastrointestinal cancers at different stages disease. Additionally, article investigates interactions between cells, well potential relationships among intratumoral bacteria, within microenvironment. The aim is propose new strategies immunotherapy targeting cells.

Language: Английский

Citations

1
Unveiling intratumoral microbiota: An emerging force for colorectal cancer diagnosis and therapy DOI Creative Commons

Jinjing Zhang,

Penghui Wang, Jiafeng Wang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107185 - 107185

Published: April 12, 2024

Microbes, including bacteria, viruses, fungi, and other eukaryotic organisms, are commonly present in multiple organs of the human body contribute significantly to both physiological pathological processes. Nowadays, development sequencing technology has revealed presence composition intratumoral microbiota, which includes Fusobacterium, Bifidobacteria, Bacteroides, shed light on significant involvement progression colorectal cancer (CRC). Here, we summarized current understanding microbiota CRC outline potential translational clinical applications diagnosis, prevention, treatment CRC. We focused reviewing microbial therapies targeting improve efficacy safety chemotherapy immunotherapy for identify biomarkers diagnosis prognosis Finally, emphasized obstacles solutions translating knowledge into practice.

Language: Английский

Citations

8
Hexokinase 2 senses fructose in tumor-associated macrophages to promote colorectal cancer growth DOI

Huiwen Yan,

Zhihua Wang, Da Teng

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(11), P. 2449 - 2467.e6

Published: Oct. 28, 2024

Language: Английский

Citations

6
Intestinal Microbiome Modulation of Therapeutic Efficacy of Cancer Immunotherapy DOI
Maruhen Amir Datsch Silveira, Richard R. Rodrigues, Giorgio Trinchieri

et al.

Gastroenterology Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
The oncobiome; what, so what, now what? DOI Open Access

Munawar Abbas,

Mark Tangney

Microbiome Research Reports, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 27, 2025

Microbial communities inhabiting various body sites play critical roles in the initiation, progression, and treatment of cancer. The gut microbiota, a highly diverse microbial ecosystem, interacts with immune cells to modulate inflammation surveillance, influencing cancer risk therapeutic outcomes. Local tissue microbiota may impact transition from premalignant states malignancy. Characterization intratumoral increasingly reveals distinct microbiomes that influence tumor growth, responses, efficacy. Various bacteria species have been reported therapies through mechanisms such as altering drug metabolism shaping microenvironment (TME). For instance, or bacterial enzymatic activity can convert prodrugs into active forms, enhancing effects or, conversely, inactivating small-molecule chemotherapeutics. Specific also linked improved responses immunotherapy, underscoring microbiome’s role Furthermore, unique signatures patients, compared healthy individuals, demonstrate diagnostic potential microbiota. Beyond gut, tumor-associated local affect therapy by inflammation, resistance. This review explores multifaceted relationships between cancer, focusing on their modulating TME, activation, members represents promising avenue for advancing precision oncology improving patient By leveraging biomarkers interventions, new strategies be developed optimize diagnosis treatment.

Language: Английский

Citations

0