International Journal of Innovative Science and Research Technology (IJISRT),
Journal Year:
2024,
Volume and Issue:
unknown, P. 2585 - 2591
Published: June 11, 2024
The
onset
of
Coronavirus
disease
2019
(COVID-19)
in
late
presented
a
severe
worldwide
health
crisis
with
widespread
morbidity
and
mortality.
Various
vaccine
platforms
have
been
rapidly
developed
approved
for
broad
use
swift
urgent
response
to
prevent
the
transmission
Severe
Acute
Respiratory
Syndrome
2
(SARS-CoV-2)
infection.
However,
these
vaccines
differ
significantly
terms
safety.
Heterologous
prime-boost
vaccination
enhances
safety
compared
homologous
vaccination,
although
it
could
lead
higher
cumulative
number
transient
adverse
events
reported
at
each
visit.
Therefore,
additional
strategies
are
necessary
improve
SARS-
CoV-2
Anecdotal
options
suggest
that
co-administration
can
reduce
effects
consequently,
avert
need
frequent
booster
doses.
This
study
reports
immunization
outcomes
against
SARS-CoV-2
virus
by
assessing
profiles
different
co-administered
BALB/c
mice.
Vaccine
combinations
comprising
mRNA/adenovirus26-vector,
mRNA/inactivated,
adenovirus26-vector/inactivated,
mRNA/adenovirus26-vector/inactivated
were
prepared
optimized
doses,
their
activities
upon
evaluated
comparison
individual
mRNA,
adenovirus26-vectored
inactivated
vaccines.
Twenty-eight
days
post-immunization,
various
treatments
through
hematological
biochemical
examination.
Importantly,
regimens
proved
safe
well-tolerated
mice,
as
evidenced
normal
values.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(26)
Published: April 7, 2024
Abstract
Brain
disorders
represent
a
significant
challenge
in
medical
science
due
to
the
formidable
blood–brain
barrier
(BBB),
which
severely
limits
penetration
of
conventional
therapeutics,
hindering
effective
treatment
strategies.
This
review
delves
into
innovative
realm
biomimetic
nanodelivery
systems,
including
stem
cell‐derived
nanoghosts,
tumor
cell
membrane‐coated
nanoparticles,
and
erythrocyte
membrane‐based
carriers,
highlighting
their
potential
circumvent
BBB's
restrictions.
By
mimicking
native
properties,
these
nanocarriers
emerge
as
promising
solution
for
enhancing
drug
delivery
brain,
offering
strategic
advantage
overcoming
barrier's
selective
permeability.
The
unique
benefits
leveraging
membranes
from
various
sources
is
evaluated
advanced
technologies
fabricating
membrane‐encapsulated
nanoparticles
capable
masquerading
endogenous
cells
are
examined.
enables
targeted
broad
spectrum
therapeutic
agents,
ranging
small
molecule
drugs
proteins,
thereby
providing
an
approach
neurocare.
Further,
contrasts
capabilities
limitations
with
traditional
methods,
underlining
enable
targeted,
sustained,
minimally
invasive
modalities.
concluded
perspective
on
clinical
translation
underscoring
transformative
impact
landscape
intractable
brain
diseases.
Journal of Thrombosis and Haemostasis,
Journal Year:
2022,
Volume and Issue:
20(11), P. 2475 - 2484
Published: Aug. 18, 2022
Abstract
Inflammation
and
coagulation
are
the
critical
responses
to
infection
that
include
leukocytes,
platelets,
vascular
endothelial
cells
responding
in
concert
eradicate
invading
pathogen.
In
sepsis,
a
variety
of
cell
surface
receptors,
including
toll‐like
Fcγ‐receptors,
G‐protein‐coupled
adhesion
detect
pathogens
elicit
thromboinflammatory
responses.
Concurrently,
molecular
patterns
released
from
host
damaged
accelerate
immune
through
binding
same
pattern
recognition
receptors.
Cytokines,
chemokines,
extracellular
vesicles
important
mediators
for
amplifying
distant
as
part
systemic
response
infections.
At
time,
communicate
with
each
other
via
direct
contact,
molecules,
paracrine
mediators,
tunneling
nanotubes,
which
regulating
inflammation
thrombus
formation.
Despite
increasing
attention
immunothrombosis
these
close
communication
systems
less
understood
but
play
role
defense
mechanisms.
this
review,
cellular
activation
intercellular
sepsis
focus
on
will
be
considered.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(2), P. 451 - 451
Published: Feb. 3, 2023
The
SARS-CoV-2
(severe
acute
respiratory
syndrome
coronavirus
responsible
for
the
COVID-19
disease)
uses
Spike
proteins
of
its
envelope
infecting
target
cells
expressing
on
membrane
angiotensin
converting
enzyme
2
(ACE2)
that
acts
as
a
receptor.
To
control
pandemic,
genetically
engineered
vaccines
have
been
designed
inducing
neutralizing
antibodies
against
proteins.
These
do
not
act
like
traditional
protein-based
vaccines,
they
deliver
message
in
form
mRNA
or
DNA
to
host
then
produce
and
expose
protein
(from
which
it
can
be
shed
soluble
form)
alert
immune
system.
Mass
vaccination
has
brought
light
various
adverse
effects
associated
with
these
based
mainly
affecting
circulatory
cardiovascular
ACE2
is
present
membrane-bound
several
cell
types,
including
mucosa
upper
gastrointestinal
tracts,
endothelium,
platelets,
plasma.
converts
vasoconstrictor
II
into
peptides
vasodilator
properties.
Here
we
review
pathways
immunization
molecular
mechanisms
through
protein,
either
from
encoded
by
mRNA-based
interferes
Renin-Angiotensin-System
governed
ACE2,
thus
altering
homeostasis
circulation
Understanding
interactions
consequent
impact
system
will
direct
diagnosis
therapy
vaccine-related
provide
information
development
personalized
considers
pathophysiological
conditions
predisposing
such
events.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 913 - 913
Published: April 20, 2024
Background:
Post-acute
sequelae
of
SARS-CoV-2
infection
(PASC)
is
a
complicated
disease
that
affects
millions
people
all
over
the
world.
Previous
studies
have
shown
PASC
impacts
10%
infected
patients
which
50–70%
are
hospitalised.
It
has
also
been
10–12%
those
vaccinated
against
COVID-19
were
affected
by
and
its
complications.
The
severity
later
development
symptoms
positively
associated
with
early
intensity
infection.
Results:
generated
health
complications
caused
involve
vast
variety
organ
systems.
Patients
diagnosed
neuropsychiatric
neurological
symptoms.
cardiovascular
system
involved
several
diseases
such
as
myocarditis,
pericarditis,
coronary
artery
reported.
Chronic
hematological
problems
thrombotic
endothelialitis
hypercoagulability
described
conditions
could
increase
risk
clotting
disorders
coagulopathy
in
patients.
Chest
pain,
breathlessness,
cough
respiratory
long-COVID
causing
distress
syndrome.
observed
immune
notable,
involving
diseases.
renal
was
impacted,
resulted
raising
issues,
fibrosis,
sepsis.
Endocrine
gland
malfunction
can
lead
to
diabetes,
thyroiditis,
male
infertility.
Symptoms
diarrhea,
nausea,
loss
appetite,
taste
among
reported
observations
due
gastrointestinal
disorders.
Skin
abnormalities
might
be
an
indication
long-term
implications
persistent
cutaneous
complaints
linked
PASC.
Conclusions:
Long-COVID
multidimensional
syndrome
considerable
public
implications,
affecting
physiological
systems
demanding
thorough
medical
therapy,
more
study
address
underlying
causes
effects
needed.
British Journal of Biomedical Science,
Journal Year:
2022,
Volume and Issue:
79
Published: Sept. 6, 2022
The
World
Health
Organisation
has
reported
that
the
viral
disease
known
as
COVID-19,
caused
by
SARS-CoV-2,
is
leading
cause
of
death
a
single
infectious
agent.
This
narrative
review
examines
certain
components
pandemic:
its
origins,
early
clinical
data,
global
and
UK-focussed
epidemiology,
vaccination,
variants,
long
COVID.
Canadian Journal of Infectious Diseases and Medical Microbiology,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
COVID-19,
caused
by
the
SARS-CoV-2
virus,
is
not
only
characterized
respiratory
symptoms
but
also
associated
with
a
wide
range
of
systemic
complications,
including
significant
hematologic
abnormalities.
This
comprehensive
review
current
literature,
using
PubMed
and
Google
Scholar,
on
pathophysiology
incidence
thromboembolic
events
in
COVID-19
patients
thromboprophylaxis.
infection
induces
prothrombotic
state
through
dysregulation
renin-angiotensin-aldosterone
system
(RAAS),
endothelial
dysfunction,
elevated
von
Willebrand
factor
(vWF),
dysregulated
immune
response
involving
complement
neutrophil
extracellular
traps
(NETs).
As
result,
complications
have
emerged
cases,
occurring
more
frequently
severe
cases
hospitalized
patients.
These
thrombotic
affect
both
venous
arterial
circulation,
increased
incidences
deep
thrombosis
(DVT),
pulmonary
embolism
(PE),
thrombosis,
myocardial
infarction
(MI).
While
DVT
PE
are
common,
literature
highlights
potential
lethal
consequences
thromboembolism
(ATE).
briefly
examines
ongoing
discussions
regarding
use
anticoagulants
for
prevention
theoretically
promising,
studies
yielded
varied
outcomes:
Some
suggest
benefits,
whereas
others
report
an
risk
bleeding
among
Therefore,
further
large-scale
needed
to
assess
efficacy
safety
thromboprophylaxis
Journal of Surgical Case Reports,
Journal Year:
2025,
Volume and Issue:
2025(4)
Published: March 29, 2025
Abstract
The
rare
condition
known
as
HELLP
syndrome
is
typified
by
hemolysis,
low
platelet
counts,
and
high
liver
enzymes.
We
report
a
case
of
25-year-old
primigravida
who
presented
at
previable
gestational
age
with
nonspecific
symptoms.
She
was
diagnosed
hepatic
infarction,
but
severe
complication
syndrome,
managed
promptly
to
prevent
maternal
morbidity
mortality.
Seminars in Thrombosis and Hemostasis,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Abstract
Travel-related
thrombosis
(TRT),
encompassing
deep
vein
(DVT)
and
pulmonary
embolism
(PE),
poses
a
significant
health
risk
associated
with
long-haul
travel.
Prolonged
immobility,
dehydration,
cabin
pressure
changes
during
flights
contribute
to
venous
stasis,
hypoxia,
hypercoagulability,
collectively
increasing
the
of
thromboembolism
(VTE).
While
absolute
TRT
is
relatively
low
in
population
overall,
it
rises
significantly
among
high-risk
groups,
including
individuals
history
VTE,
thrombophilia,
pregnancy,
or
recent
surgery.
This
review
explores
epidemiology,
pathophysiology,
clinical
presentation,
diagnostic
evaluation
while
highlighting
importance
early
recognition
prevention.
Risk
assessment
models
can
provide
guidance
for
identifying
at-risk
travelers.
Preventive
strategies
include
pharmacological
prophylaxis
low-molecular-weight
heparin
(LMWH)
nonpharmacological
measures
such
as
compression
stockings,
intermittent
pneumatic
compression,
mobility
exercises,
hydration.
Guidelines
from
international
societies
recommend
tailored
interventions
based
on
individual
profiles,
randomized
controlled
trials
are
scarce.
Given
that
travel
dramatically
expands,
this
critically
analyzes
available
management
various
settings,
aiming
increase
awareness
global
issue.
