Occurrence, potential ecological risks, and degradation of endocrine disrupter, nonylphenol, from the aqueous environment

Chemosphere, Journal Year: 2021, Volume and Issue: 275, P. 130013 - 130013

Published: Feb. 21, 2021

Language: Английский

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Exposure to phthalates and female reproductive health: A literature review

Reproductive Toxicology, Journal Year: 2022, Volume and Issue: 109, P. 61 - 79

Published: March 3, 2022

Language: Английский

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Plastics derived endocrine‐disrupting compounds and their effects on early development

Birth Defects Research, Journal Year: 2020, Volume and Issue: 112(17), P. 1308 - 1325

Published: June 1, 2020

Abstract Despite the fact that estrogenic effects of bisphenols were first described 80 years ago, recent data about its potential negative impact on birth outcome parameters raises a strong rationale to investigate further. The adverse health plastics recommend measure impacts endocrine‐disrupting compounds (EDCs) such as (BPA, BPS, BPF), bis(2‐ethylhexyl) phthalate, and dibutyl phthalate (DBP) in human health. Exposure these utero may program diseases testis, prostate, kidney abnormalities immune system, cause tumors, uterine hemorrhage during pregnancy polycystic ovary. These also control processes epigenetic transgenerational inheritance adult‐onset by modulating DNA methylation epimutations reproductive cells. early developmental stage is most susceptible window for genomic programming. critical stages events normal lie between many transitions occurring spermatogenesis, egg fertilization fully formed fetus. As cells begin grow differentiate, there are balances hormones, protein synthesis. Data emerging how plastic‐derived affect embryogenesis, placentation feto‐placental development since pregnant women unborn fetuses often exposed factors preconception throughout gestation. Impaired ultimately influences fetal outcomes at center disorders contributes an independent risk factor adult chronic diseases. This review will summarize current status exposure plastic derived EDCs growth, gene expression, angiogenic activities process their possible outcomes.

Language: Английский

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The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Frontiers in Public Health, Journal Year: 2020, Volume and Issue: 8

Published: Aug. 28, 2020

Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods particularly susceptible to endocrine disorders which prenatal exposure phthalates cause. There is increasing evidence concerning the potential for during pregnancy. This article aims review impairment outcomes exposure. Prenatal give rise alterations thyroid sex hormone levels in pregnant women offspring disruption circulating 25-hydroxyvitamin D mother, result adverse maternal such as preterm birth, preeclampsia, glucose mother cryptorchidism, hypospadias, well shorter anogenital distance newborns, growth restriction not only infants but also early adolescence childhood. The relationship phthalate with human beings was often sex-specific associations. Due potentially harmful influence exposure, steps should be taken prevent or reduce

Language: Английский

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Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals

Endocrine Reviews, Journal Year: 2021, Volume and Issue: 42(3), P. 295 - 353

Published: Jan. 3, 2021

Abstract The burden of adverse pregnancy outcomes such as preterm birth and low weight is considerable across the world. Several risk factors for have been identified. One factor receiving attention in recent years gestational exposure to endocrine-disrupting chemicals (EDCs). Humans are exposed a multitude environmental with known properties, evidence suggests these EDCs potential disrupt maternal-fetal environment culminating outcomes. This review addresses impact maternal fetal natural man-made disrupting milieu human leading outcomes—a adult-onset noncommunicable diseases, role lifestyle play mitigating or amplifying effects EDCs, underlying mechanisms mediators involved, research directions on which focus future investigations help alleviate EDC exposure.

Language: Английский

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Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis

Environmental Health, Journal Year: 2022, Volume and Issue: 21(1)

Published: May 16, 2022

To conduct a comprehensive systematic review and meta-analysis to estimate the relationship between endocrine-disrupting chemicals (EDCs), including polychlorinated biphenyls (PCBs), poly-brominated diphenyl ethers (PBDEs), phthalates (PAEs), per- polyfluoroalkyl substances (PFAS) exposure risk of gestational diabetes mellitus (GDM).Relevant studies from their inception November 2021 were identified by searching EMBASE, PubMed, Web Science. The cohort case-control that reported effect size with 95% confidence intervals (CIs) EDC GDM selected. heterogeneity among included was quantified I2 statistic. Publication bias evaluated through Begg Egger tests.Twenty-five articles total 23,796 participants found. Results indicated PCBs has significant influence on incidence (OR = 1.14; CI 1.00--1.31; n 8). found be associated PBDE 1.32; 1.15-1.53; 4). PAEs PFASs also positively GDM, summary ORs 1.10 (95% 1.03-1.16; 7 for PAEs) 1.09 1.02-1.16; 11 PFASs), respectively. When only considered, OR 0.99 0.91-1.09; 5). Meanwhile, PBDEs, PAEs, 1.12 1.00-1.26; 2), 1.08 1.02-1.15; 5), 1.06 1.00-1.12; 8), Beggs tests did not show publication bias, sensitivity analyses change results in this meta-analysis.These support certain EDCs, PCBs, PFAS, increase GDM. Further large-sample epidemiologic researches mechanistic are needed verify potential biological mechanisms. These public health significance because daily is expected development.

Language: Английский

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Endocrine Disrupting Chemicals’ Effects in Children: What We Know and What We Need to Learn?

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11899 - 11899

Published: Oct. 7, 2022

Thousands of natural or manufactured chemicals were defined as endocrine-disrupting (EDCs) because they can interfere with hormone activity and the endocrine system. We summarize discuss what we know still need to learn about EDCs' pathogenic mechanisms action, well effects most common EDCs on system health in childhood. The MEDLINE database (PubMed) was searched 13 May 2022, filtering for EDCs, diseases, children. are a group compounds high heterogeneity, but usually disrupt by mimicking interfering hormones body's hormonal balance through other mechanisms. Individual studied detail, while humans' "cocktail effect" is unclear. In utero, early postnatal life, and/or pubertal development highly susceptible periods exposure. Human epidemiological studies suggest that affect prenatal growth, thyroid function, glucose metabolism, obesity, puberty, fertility several Further needed clarify which mainly act epigenetic processes. A better understanding human crucial developing future regulatory strategies prevent exposure ensure children today, generations, environment.

Language: Английский

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Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure

Cell Reports, Journal Year: 2022, Volume and Issue: 38(9), P. 110442 - 110442

Published: March 1, 2022

Polychlorinated biphenyls (PCBs) are developmental neurotoxicants implicated as environmental risk factors for neurodevelopmental disorders (NDDs). Here, we report the effects of prenatal exposure to a human-relevant mixture PCBs on DNA methylation profiles mouse placenta and fetal brain. Thousands differentially methylated regions (DMRs) distinguish brain from PCB-exposed mice sex-matched vehicle controls. In both brain, PCB-associated DMRs enriched functions related neurodevelopment cellular signaling within bivalent chromatin. The PCB overlap significantly map shared subset genes Wnt signaling, Slit/Robo expressed in NDD models. consensus also with human placenta. These results demonstrate that contains relevant an NDD.

Language: Английский

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The effect of endocrine-disrupting chemicals on placental development

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 21, 2023

Endocrine-disrupting chemicals (EDCs) or endocrine disruptors are substances that either naturally occurring artificial and released into the natural environment. Humans exposed to EDCs through ingestion, inhalation, skin contact. Many everyday household items, such as plastic bottles containers, liners of metal food cans, detergents, flame retardants, food, gadgets, cosmetics, pesticides, contain disruptors. Each hormone has a unique chemical makeup structural attributes. The way hormones connect receptors is described “lock key” mechanism, with each serving key (lock). This mechanism enabled by complementary shape their hormone, which allows activate receptors. exogenous compounds have negative impact on organisms’ health interacting functioning system. associated cancer, cardiovascular risk, behavioural disorders, autoimmune abnormalities, reproductive disorders. exposure in humans highly harmful during critical life stages. Nonetheless, effect placenta often underestimated. especially sensitive due its abundance In this review, we evaluated most recent data effects placental development function, including heavy metals, plasticizers, UV filters preservatives. under evaluation evidence from human biomonitoring found nature. Additionally, study indicates important knowledge gaps will direct future research topic.

Language: Английский

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Cumulative Exposure to Phthalates and Their Alternatives and Associated Female Reproductive Health: Body Burdens, Adverse Outcomes, and Underlying Mechanisms

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(22), P. 8189 - 8212

Published: May 17, 2023

The global birth rate has recently shown a decreasing trend, and exposure to environmental pollutants been identified as potential factor affecting female reproductive health. Phthalates have widely used plasticizers in plastic containers, children's toys, medical devices, their ubiquitous presence endocrine-disrupting already raised particular concerns. Phthalate linked various adverse health outcomes, including diseases. Given that many phthalates are gradually being banned, growing number of phthalate alternatives becoming popular, such di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH), di(2-ethylhexyl) adipate (DEHA), terephthalate (DEHTP), they beginning wide range effects. Studies may disrupt function by altering the estrous cycle, causing ovarian follicular atresia, prolonging gestational which raises concerns about risks. Herein, we summarize effects common different models, levels influence system, on impairment, pregnancy offspring development. Additionally, scrutinize hormone signaling, oxidative stress, intracellular signaling explore underlying mechanisms action health, because these chemicals affect tissues directly or indirectly through endocrine disruption. declining trends capacity ability negatively impact more comprehensive study is needed understand human body mechanisms. These findings an important role improving turn complications during pregnancy.

Language: Английский

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