Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

Cellular & Molecular Biology Letters, Journal Year: 2022, Volume and Issue: 27(1)

Published: Aug. 19, 2022

Human mesenchymal stem cells (MSCs) are primary multipotent capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role MSCs in tissue homeostasis, aging-related diseases, cellular therapy is clinically suggested. As aging a universal problem that has large socioeconomic effects, an improved understanding the concepts can direct public policies reduce its adverse impacts on healthcare system humanity. Several studies have been carried out over several years to understand phenomenon different factors affecting human aging. A reduced ability adult cell populations reproduce regenerate one main contributors process. In this context, senescence major challenge front advancement. Many factors, ranging from genetic metabolic pathways extrinsic through various signaling pathways, involved regulating mechanism MSC senescence. To better reverse senescence, review highlights underlying mechanisms signs discusses strategies combat

Language: Английский

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Ageing as a software design flaw

Genome biology, Journal Year: 2023, Volume and Issue: 24(1)

Published: March 27, 2023

Abstract Ageing is inherent to all human beings, yet why we age remains a hotly contested topic. Most mechanistic explanations of ageing posit that caused by the accumulation one or more forms molecular damage. Here, I propose not because inevitable damage hardware but rather intrinsic design flaws in software, defined as DNA code orchestrates how single cell develops into an adult organism. As developmental software runs, its sequence events reflected shifting cellular epigenetic states. Overall, suggest understand need decode our and flow information throughout life course.

Language: Английский

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Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 18, 2025

Language: Английский

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Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine

Aging, Journal Year: 2022, Volume and Issue: 14(6), P. 2475 - 2506

Published: March 29, 2022

Aging | doi:10.18632/aging.203960. Frank W. Pun, Geoffrey Ho Duen Leung, Hoi Wing Bonnie Hei Man Liu, Xi Long, Ivan V. Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evgeny Izumchenko, Alexey Moskalev, João Pedro de Magalhães, Alex Zhavoronkov

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Human Ageing Genomic Resources: updates on key databases in ageing research

Nucleic Acids Research, Journal Year: 2023, Volume and Issue: 52(D1), P. D900 - D908

Published: Nov. 2, 2023

Abstract Ageing is a complex and multifactorial process. For two decades, the Human Genomic Resources (HAGR) have aided researchers in study of various aspects ageing its manipulation. Here, we present key features recent enhancements these resources, focusing on six main databases. One database, GenAge, focuses genes related to ageing, featuring 307 linked human 2205 associated with longevity model organisms. AnAge longevity, life-history across animal species, containing data 4645 species. DrugAge includes information about 1097 drugs compounds organisms such as mice, rats, flies, worms yeast. GenDR provides list 214 life-extending benefits dietary restriction CellAge contains catalogue 866 cellular senescence. The LongevityMap serves repository for genetic variants encompassing 3144 pertaining 884 genes. Additionally, HAGR tools well gene expression signatures restriction, replicative senescence based meta-analyses. Our databases are integrated, regularly updated, manually curated by experts. freely available online (https://genomics.senescence.info/).

Language: Английский

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Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4607 - 4607

Published: Oct. 30, 2023

Pentadecanoic acid (C15:0) is an essential odd-chain saturated fatty with broad activities relevant to protecting cardiometabolic, immune, and liver health. C15:0 activates AMPK inhibits mTOR, both of which are core components the human longevity pathway. To assess potential for enhance processes associated healthspan, we used cell-based molecular phenotyping assays compare three longevity-enhancing candidates: acarbose, metformin, rapamycin. (n = 36 in 10 12 cell systems) rapamycin 32 had most clinically relevant, dose-dependent activities. At their optimal doses, (17 µM) (9 shared 24 across systems, including anti-inflammatory (e.g., lowered MCP-1, TNFα, IL-10, IL-17A/F), antifibrotic, anticancer activities, further supported by previously published vitro vivo studies. Paired prior demonstrated abilities target pathways, hallmarks aging, aging rate biomarkers, type 2 diabetes, heart disease, cancer, nonalcoholic our results support as nutrient equivalent to, or surpassing, leading candidate compounds.

Language: Английский

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Aging as a loss of morphostatic information: A developmental bioelectricity perspective

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 97, P. 102310 - 102310

Published: April 17, 2024

Language: Английский

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Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Age-related diseases have emerged as a global concern the population ages. Consequently, understanding underlying causes of aging and exploring potential anti-aging interventions is imperative. In females, ovaries serve principal organs responsible for ovulation production female hormones. The are related to infertility, menopause, associated menopausal syndromes, with menopause representing culmination ovarian aging. Current evidence indicates that may contribute dysfunction across multiple organ systems, including, but not limited to, cognitive impairment, osteoporosis, cardiovascular disease. Nevertheless, due widespread distribution sex hormone receptors throughout body, affects only these specific also influences broader spectrum age-related in women. Despite this, impact on overall has been largely neglected. This review provides thorough summary diseases, encompassing nervous, circulatory, locomotor, urinary, digestive, respiratory, endocrine systems. Additionally, we outlined prospective therapeutic approaches addressing both aim mitigating their impacts preserving women's fertility, physical health, psychological well-being.

Language: Английский

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Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 10, 2025

Abstract In the context of global ageing, prevalence neurodegenerative diseases and dementia, such as Alzheimer’s disease (AD), is increasing. However, current symptomatic disease-modifying therapies have achieved limited benefits for in clinical settings. Halting progress neurodegeneration cognitive decline or even improving impaired cognition function are clinically meaningful goals treatments diseases. Ageing primary risk factor their associated comorbidities, vascular pathologies, elderly individuals. Thus, we aim to elucidate role ageing from perspective a complex system, which brain core peripheral organs tissues form holistic network support functions. During progressive deterioration structure entire body hampers its active adaptive responses various stimuli, thereby rendering individuals more vulnerable Consequently, propose that prevention treatment should be grounded antiageing rejuvenation means complemented by interventions targeting disease-specific pathogenic events. This integrated approach promising strategy effectively prevent, pause slow down progression

Language: Английский

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Anti-aging effects and mechanisms of anthocyanins and their intestinal microflora metabolites

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(8), P. 2358 - 2374

Published: Sept. 21, 2022

Aging, a natural and inevitable physiological process, is the primary risk factor for all age-related diseases; it severely threatens health of individuals places heavy burden on public health-care system. Thus, strategies to extend lifespan prevent treat diseases have been gaining increasing scientific interest. Anthocyanins (ACNs) are subclass flavonoids widely distributed in fruits vegetables. Growing evidence suggests that ACNs delay aging relieve diseases. However, owing low bioavailability ACNs, their gut metabolites proposed play critical role mediating benefits. In this review, we introduce biological fate after consumption highlight (phenolic acids) from intestinal microorganisms. Additionally, exhibit outstanding anti-aging ability Caenorhabditis elegans, Drosophila melanogaster, mouse models, probably associated with antioxidation, anti-inflammation, protein homeostasis, antiglycation, mitochondrial function, inhibition insulin/IGF-1 signaling (IIS). great application prospects as functional foods drugs manage Further investigation should focus interaction between microbiota, including clarifying complex metabolic pathway maximizing effects ACNs.

Language: Английский

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