Dietary genistein increases microbiota-derived short chain fatty acid levels, modulates homeostasis of the aging gut, and extends healthspan and lifespan

Pharmacological Research, Journal Year: 2023, Volume and Issue: 188, P. 106676 - 106676

Published: Jan. 21, 2023

Age-related gastrointestinal decline contributes to whole-organism frailty and mortality. Genistein is known have beneficial effects on age-related diseases, but its precise role in homeostasis of the aging gut remains be elucidated. Here, wild-type mice Zmpste24-/- progeroid were used investigate genistein lifespan mammals. A series longitudinal, clinically relevant measurements performed evaluate effect healthspan. It was found that dietary promoted a healthier longer life associated with decrease levels systemic inflammatory cytokines mice. Furthermore, ameliorated dysfunctions, such as intestinal inflammation, leaky gut, impaired epithelial regeneration. distinct genistein-mediated alteration microbiota observed by increasing Lachnospira abundance short-chain fatty acid (SCFA) production. Further fecal transplantation dirty cage sharing experiments indicated from genistein-fed rejuvenated extended demonstrated genistein-associated SCFAs alleviated tumor necrosis factor alpha-induced organoid damage. Moreover, propionate regulatory T cell-derived interleukin 10 production, which macrophage-derived inflammation. This study provided first data, authors' knowledge, indicating modulates extends healthspan existence link between provides rationale for interventions against age-associated frailty.

Language: Английский

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Plant anthocyanins: classification, biosynthesis, regulation, bioactivity, and health benefits

Plant Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 217, P. 109268 - 109268

Published: Nov. 4, 2024

Language: Английский

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Anthocyanins-natural pigment of colored rice bran: Composition and biological activities

Food Research International, Journal Year: 2023, Volume and Issue: 175, P. 113722 - 113722

Published: Nov. 23, 2023

Language: Английский

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Unveiling the multifaceted world of anthocyanins: Biosynthesis pathway, natural sources, extraction methods, copigmentation, encapsulation techniques, and future food applications

Food Research International, Journal Year: 2024, Volume and Issue: 187, P. 114437 - 114437

Published: April 28, 2024

Language: Английский

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Bioavailability of Anthocyanins: Whole Foods versus Extracts

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1403 - 1403

Published: May 7, 2024

Anthocyanins have gained significant popularity in recent years for their diverse health benefits, yet limited bioavailability poses a challenge. To address this concern, technologies emerged to enhance anthocyanin concentration, often isolating these compounds from other food constituents. However, the extent which isolated anthocyanins confer benefits compared whole-food counterparts remains unclear. This review explores current literature on and metabolism body, with focus comparing when consumed as extracts versus whole foods rich anthocyanins, drawing vitro, vivo, human clinical studies. While direct comparisons between isolates are scarce, prevailing evidence favours consumption over extracts. Further investigations, preferably comparisons, needed validate findings elucidate nuanced interplay matrices, informing future research directions practical recommendations.

Language: Английский

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Phytochemical analysis, bioactivity, and molecular docking studies of Myrtus communis L. seeds and fruit peel extracts demonstrating antioxidant and anti-tyrosinase properties

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 15, 2025

Myrtus communis L, is an edible medicinal plant with fruit berries used to manufacture liquors, aromatise wine, and sweet foods, beside several folk-medicinal uses. The also endemic Libya, holds promise for its properties, including anti-inflammatory, antioxidant, wound healing, appetising effects. This work aims explore the phytoconstituents present in seeds peels of L by GC-MS LC-ESI-MS analysis, respectively. demonstrated vitro silico antioxidant anti-tyrosinase activities extracts. analysis indicated presence 11 fatty acids myrtle representing 78.61% total seeds' acid contents, where unsaturated linolenic (C18:3) was major (23.11%). Moreover, seven anthocyanins were identified relative percentage 59.84% related peaks area positive ion mode chromatogram. Among compounds, petunidin 3-O-glucoside Malvidin 3-O-rutinoside most abundant at 12.48% and11.87%, Antioxidant assay showed that ethanolic extract exhibited higher DPPH-free radical scavenging compared chloroform (6.89 ± 0.12 2.65 0.03, respectively). Similarly, induced ferric reducing power (FRAP) (4.87 1.02 2.10 0.9, greatest inhibitory effect against tyrosinase enzyme IC50 126.35 0.92 activity 135.27 1.23. tested extracts displayed lower level inhibition standard arbutin (IC50 76.9 0.0). results molecular docking simulations suggest anthocyanins, particularly Cyanidin-3-O-rutinoside, exhibit significant binding affinity could potentially serve as effective natural inhibitors. These compounds may interfere enzyme's catalytic interacting key residues active site.

Language: Английский

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Toxicity of microplastics polystyrene to freshwater planarians and the alleviative effects of anthocyanins

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: 282, P. 107310 - 107310

Published: March 4, 2025

Language: Английский

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Cyanidin Alleviated CCl4-Induced Acute Liver Injury by Regulating the Nrf2 and NF-κB Signaling Pathways

Antioxidants, Journal Year: 2022, Volume and Issue: 11(12), P. 2383 - 2383

Published: Dec. 1, 2022

Acute liver injury has multiple causes and can result in failure. In this study, we evaluated the hepatoprotective ability of cyanidin (Cy) investigated its associated mechanisms. Cy administration significantly dose-dependently ameliorated acute induced by carbon tetrachloride (CCl4). High-dose showed effects comparable to those achieved positive control (silymarin). Severe oxidative stress inflammatory responses tissue CCl4 were mitigated supplementation. The total antioxidant capacity activity superoxide dismutase, catalase, glutathione peroxidase increased content malondialdehyde, lipid peroxide, tumor necrosis factor α, interleukin-1β, interleukin-6 decreased. Additionally, Nrf2 NF-κB signaling pathways, which regulate antioxidative responses, analyzed using quantitative real-time polymerase chain reaction western blot assay. treatment not only transcription expression but also decreased signaling. Moreover, molecular docking simulation indicated that had high affinity for Keap1 NF-κB/p65, may promote nuclear translocation inhibit NF-κB. summary, exerted anti-inflammatory increasing inhibiting pathway, demonstrating potential as a therapeutic agent injury.

Language: Английский

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Effects of in vitro fecal fermentation on the metabolism and antioxidant properties of cyanidin-3-O-glucoside

Food Chemistry, Journal Year: 2023, Volume and Issue: 431, P. 137132 - 137132

Published: Aug. 18, 2023

Language: Английский

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Enhancing the anti-fatigue effect of ginsenoside extract by Bifidobacterium animalis subsp. lactis CCFM1274 fermentation through biotransformation of Rb1, Rb2 and Rc to Rd

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105251 - 105251

Published: Oct. 1, 2024

Language: Английский

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