Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 97 - 107
Published: Dec. 30, 2023
Language: Английский
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Sept. 26, 2023
Plastic pollution is rapidly increasing worldwide, causing adverse impacts on the environment, wildlife and human health. One tempting solution to this crisis upcycling plastics into products with engineered microorganisms; however, remains challenging due complexity in conversion. Here we present a synthetic microbial consortium that efficiently degrades polyethylene terephthalate hydrolysate subsequently produces desired chemicals through division of labor. The involves two Pseudomonas putida strains, specializing terephthalic acid ethylene glycol utilization respectively, achieve complete substrate assimilation. Compared its monoculture counterpart, exhibits reduced catabolic crosstalk faster deconstruction, particularly when concentrations are high or crude used. It also outperforms polyhydroxyalkanoates serves as target product confers flexible tuning population modulation for cis-cis muconate synthesis. This work demonstrates consortia promising, effective platform may facilitate polymer environmental sustainability.
Language: Английский
Citations
59
Trends in biotechnology, Journal Year: 2024, Volume and Issue: 42(7), P. 895 - 909
Published: Feb. 5, 2024
Cells provide dynamic platforms for executing exogenous genetic programs in synthetic biology, resulting highly context-dependent circuit performance. Recent years have seen an increasing interest understanding the intricacies of circuit–host relationships, their influence on bioengineering workflow, and devising strategies to alleviate undesired effects. We overview how emerging interactions, such as growth feedback resource competition, impact both deterministic stochastic behaviors. also emphasize control mitigating these unwanted This review summarizes latest advances current state host-aware resource-aware design gene circuits.
Language: Английский
Citations
20
Environment International, Journal Year: 2023, Volume and Issue: 174, P. 107899 - 107899
Published: March 27, 2023
Nanoplastics (NPs) are increasingly perceived as an emerging threat to terrestrial environments, but the adverse impacts of NPs on soil fauna and mechanisms behind these negative outcomes remain elusive. Here, a risk assessment was conducted model organism (earthworm) from tissue cell. Using palladium-doped polystyrene NPs, we quantitatively measured nanoplastic accumulation in earthworm investigated its toxic effects by combining physiological with RNA-Seq transcriptomic analyses. After 42-day exposure, accumulated up 15.9 143.3 mg kg-1 for low (0.3 kg-1) high (3 dose groups, respectively. retention led decrease antioxidant enzyme activity reactive oxygen species (O2- H2O2), which reduced growth rate 21.3 %-50.8 % caused pathological abnormalities. These were enhanced positively charged NPs. Furthermore, observed that irrespective surface charge, after 2 h gradually internalized coelomocytes (∼0.12 μg per cell) mainly amassed at lysosomes. Those agglomerations stimulated lysosomal membranes lose stability even rupture, resulting impeded autophagy process cellular clearance, eventually coelomocyte death. In comparison negatively nanoplastics, exerted 83 higher cytotoxicity. Our findings provide better understanding how posed harmful have important implications evaluating ecological
Language: Английский
Citations
41
Ocean & Coastal Management, Journal Year: 2024, Volume and Issue: 249, P. 107012 - 107012
Published: Jan. 17, 2024
Language: Английский
Citations
9
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154585 - 154585
Published: Aug. 5, 2024
Language: Английский
Citations
8
Chemosphere, Journal Year: 2024, Volume and Issue: 352, P. 141451 - 141451
Published: Feb. 16, 2024
Language: Английский
Citations
5
Next Sustainability, Journal Year: 2025, Volume and Issue: 6, P. 100098 - 100098
Published: Jan. 1, 2025
Language: Английский
Citations
0
Published: Feb. 6, 2025
Language: Английский
Citations
0
Humanities and Social Sciences Communications, Journal Year: 2025, Volume and Issue: 12(1)
Published: May 10, 2025
Language: Английский
Citations
0
UTTAR PRADESH JOURNAL OF ZOOLOGY, Journal Year: 2024, Volume and Issue: 45(13), P. 170 - 188
Published: June 10, 2024
The growing problem of antibiotic resistance calls for a paradigm shift in medication discovery. Fortunately, the enormous oceans, home to an incredible diversity life, provide viable solution: marine metabolites. These unusual chemicals have potential treating wide range diseases. This present study investigates great using these marine-derived gems disease management techniques. Despite difficulty procuring and isolating organisms, discovering most effective metabolites, traversing lengthy research pipelines, rewards are apparent. To demonstrate power resources, paper examines successful case studies. Each delves deeply into single metabolite, including its source organism, it targets, precise mechanism by which metabolite disrupts process. We'll look at results clinical trials that examined efficacy safety medications, eventually exposing real-world influence on patient outcomes after incorporating them treatment plans. Examining cases provides useful insights resources producing novel opening path further discovery innovation battle against
Language: Английский
Citations
3