Anti‐inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(4), P. 1882 - 1902

Published: Feb. 15, 2024

Abstract Berberis vulgaris ( B. or barberry) is a medicinal plant that has been used for various purposes in traditional medicine. Berberine one of the main alkaloids isolated from and other plants. Both berberine have shown anti‐inflammatory, antioxidant, immunomodulatory effects different experimental models clinical trials. This review aims to summarize current evidence on mechanisms applications modulating inflammation, oxidative stress, immune responses. The literature search was performed using PubMed, Scopus, Google Scholar databases until August 2023. results indicated could inhibit production pro‐inflammatory cytokines, such as tumor necrosis factor‐alpha (TNF‐α), interleukin‐1β (IL‐1β), interleukin 6 (IL‐6), interleukin‐17 (IL‐17), enhance expression anti‐inflammatory 10 (IL‐10) transforming growth factor‐β (TGF‐β), cell types tissues. can also scavenge free radicals, increase antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduce lipid peroxidation DNA damage. reported exert beneficial several inflammatory, oxidative, immune‐related diseases, diabetes, obesity, cardiovascular neurodegenerative autoimmune allergic infections. However, more studies are needed elucidate optimal doses, safety profiles, potential interactions with drugs natural compounds.

Language: Английский

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Withania somnifera Ameliorates Doxorubicin-Induced Nephrotoxicity and Potentiates Its Therapeutic Efficacy Targeting SIRT1/Nrf2, Oxidative Stress, Inflammation, and Apoptosis

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 248 - 248

Published: Feb. 12, 2025

Background: Doxorubicin (DOX) is a very powerful chemotherapy drug. However, its severe toxicity and potential for resistance development limit application. Withania somnifera L. Dunal (WIT) has therapeutic capacities, including anti-inflammatory, antioxidant, anticancer activities. This study investigates the preventative benefits of standardized WIT extract against DOX-induced renal damage in vivo. We also investigate synergistic effects combining DOX to improve efficacy breast cancer cells (MCF7-ADR). Methods: employed an animal model where rats were administered 300 mg/kg/day orally duration 14 days. Rats received injections at dose 5 mg/kg, total 15 mg, on 6th, 8th, 10th Results: Present results revealed that reduced increase levels blood urea creatinine activity kidney injury molecule-1. tissue damage, oxidative stress, pro-inflammatory markers. alleviated nuclear factor erythroid 2-related 2, heme oxygenase-1, sirtuin 1 tissues. modulated factor-κB decreased apoptotic indicators. Furthermore, improves DOX's capacity kill drug-resistant MCF7-ADR by arresting cell cycle promoting apoptosis. Chemical analysis root 34 distinct compounds, alkaloids, withanolides, flavanones, fatty acids. Conclusions: These constituents synergistically contribute WIT's anti-apoptotic properties. In addition, they confirm ability reduce systemic while improving treatment efficacy.

Language: Английский

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Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 152, P. 113225 - 113225

Published: June 4, 2022

Nephrotoxicity (NT) is a renal-specific situation caused by different toxins and drugs like non-steroidal anti-inflammatory (NSAIDs). NSAIDs diclofenac (DCF) lead to glomerular dysfunction. Pentoxifylline (PTX) berberine (BER) have antioxidant properties. Thus, the objective of present study was investigate ameliorative effect PTX, BER their combination against DCF-mediated acute NT. Induction NT done via DCF injection (150 mg/kg I.P, for 6 days) in rats. PTX 200 mg/kg, were administrated days prior concurrently with additional days. Acute evaluated biochemically histopathologically measuring blood urea (BU), serum creatinine (SCr), kidney injury molecule-1(KIM-1), integrin (ITG), vitronectin (VTN), interleukin (IL)-18, Neutrophil gelatinase-associated lipocalin (NGAL), filtration rate (GFR), superoxide dismutase (SOD) glutathione (GSH) malondialdehyde (MDA) scoring histopathological alterations. significantly (P < 0.05) attenuated biochemical changes amelioration BU, SCr, KIM-1, ITG, VTN, IL-18, NGAL, GFR, SOD, GSH, MDA The combined effects produced more significant than either or when used alone DCF-induced In conclusion, BTX found potential renoprotective rats inhibiting inflammatory reactions oxidative stress.

Language: Английский

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A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1294 - 1294

Published: Jan. 29, 2023

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia caused resistance to insulin action, inadequate secretion, or excessive glucagon production. Numerous studies have linked diabetes and oxidative stress. People with usually exhibit high stress due persistent chronic hyperglycemia, which impairs the activity antioxidant defense system promotes formation free radicals. Recently, several focused on exploring natural antioxidants improve mellitus.

Language: Английский

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Natural bioactive compounds-doxorubicin combinations targeting topoisomerase II-alpha: Anticancer efficacy and safety

Toxicology and Applied Pharmacology, Journal Year: 2023, Volume and Issue: 461, P. 116405 - 116405

Published: Jan. 28, 2023

Language: Английский

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Esculetin improves inflammation of the kidney via gene expression against doxorubicin-induced nephrotoxicity in rats: In vivo and in silico studies

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105159 - 105159

Published: Sept. 1, 2024

Language: Английский

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Natural products in traditional Chinese medicine: molecular mechanisms and therapeutic targets of renal fibrosis and state-of-the-art drug delivery systems

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116039 - 116039

Published: Dec. 28, 2023

Renal fibrosis (RF) is the end stage of several chronic kidney diseases. Its series changes include excessive accumulation extracellular matrix, epithelial-mesenchymal transition (EMT) renal tubular cells, fibroblast activation, immune cell infiltration, and apoptosis. RF can eventually lead to dysfunction or even failure. A large body evidence suggests that natural products in traditional Chinese medicine (TCM) have great potential for treating RF. In this article, we first describe recent advances treatment by clarify their mechanisms action. They ameliorate disease phenotype, which includes apoptosis, endoplasmic reticulum stress, EMT, affecting relevant signaling pathways molecular targets, thereby delaying reversing fibrosis. We also present roles nanodrug delivery systems, been explored address drawback low oral bioavailability products. This may provide new ideas using treatment. Finally, insights into clinical prospects herbal

Language: Английский

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Curcumin Ameliorates Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity Via Suppressing Oxidative Stress and Modulating iNOS, NF-κB, and TNF-α in Rats

Cardiovascular Toxicology, Journal Year: 2021, Volume and Issue: 22(2), P. 152 - 166

Published: Nov. 27, 2021

Language: Английский

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Geraniol Ameliorates Doxorubicin-Mediated Kidney Injury through Alteration of Antioxidant Status, Inflammation, and Apoptosis: Potential Roles of NF-κB and Nrf2/Ho-1

Nutrients, Journal Year: 2022, Volume and Issue: 14(8), P. 1620 - 1620

Published: April 13, 2022

Doxorubicin-mediated kidney impairment is a serious problem in cancer treatment. Accordingly, this work investigated the ability of geraniol to modulate doxorubicin-induced damage using rat model. Rats were randomly assigned four groups: control, doxorubicin (20 mg/kg, intraperitoneal, i.p.), plus 100 mg/kg geraniol, and 200 geraniol. A single injection triggered impairment, as evidenced by altered serum creatinine, blood urea nitrogen, albumin values; it also caused histological changes architecture. Additionally, enhanced lipid peroxidation while lowering reduced glutathione, catalase activity, expression glutathione peroxidase superoxide dismutase. Interestingly, pre-treatment with rescued alterations antioxidant parameters, enzymatic inflammatory apoptosis-mediating gene proteins. Moreover, prophylactic treatment preserved most characteristics dose-dependent manner. These findings support that could protect against doxorubicin-mediated dysfunction. However, further research needed clarify mechanisms geraniol's protective effects

Language: Английский

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Naringin ameliorates 5-fluorouracil induced cardiotoxicity: An insight into its modulatory impact on oxidative stress, inflammatory and apoptotic parameters

Tissue and Cell, Journal Year: 2023, Volume and Issue: 81, P. 102035 - 102035

Published: Feb. 5, 2023

Language: Английский

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