Mapping the multicausality of Alzheimer’s disease through group model building DOI Creative Commons
Jeroen F. Uleman, René J. F. Melis, Rick Quax

et al.

GeroScience, Journal Year: 2020, Volume and Issue: 43(2), P. 829 - 843

Published: Aug. 11, 2020

Abstract Alzheimer’s disease (AD) is a complex, multicausal disorder involving several spatiotemporal scales and scientific domains. While many studies focus on specific parts of this system, the complexity AD rarely studied as whole. In work, we apply systems thinking to map out known causal mechanisms risk factors ranging from intracellular psychosocial in sporadic AD. We report first systemic loop diagram (CLD) for AD, which result an interdisciplinary group model building (GMB) process. The GMB was based input experts multiple domains all proposed were supported by literature. CLD elucidates interaction feedback that contribute cognitive decline midlife onward described experts. As immediate outcome, observed non-trivial reinforcing loops at spatial scales, are considered within same theoretical framework. also high centrality modifiable such social relationships physical activity, suggests they may be promising leverage points interventions. This illustrates how process lead novel insights into complex disorders. Furthermore, step development computational simulating effects

Language: Английский

Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation DOI Open Access
Shrey Grover, Wen Wen, Vighnesh Viswanathan

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(9), P. 1237 - 1246

Published: Aug. 22, 2022

Language: Английский

Citations

118
Information decomposition and the informational architecture of the brain DOI Creative Commons
Andrea I. Luppi, Fernando Rosas, Pedro A. M. Mediano

et al.

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(4), P. 352 - 368

Published: Jan. 9, 2024

To explain how the brain orchestrates information-processing for cognition, we must understand information itself. Importantly, is not a monolithic entity. Information decomposition techniques provide way to split into its constituent elements: unique, redundant, and synergistic information. We review disentangling redundant interactions redefining our understanding of integrative function neural organisation. navigates trade-offs between redundancy synergy, converging evidence integrating structural, molecular, functional underpinnings synergy redundancy; their roles in cognition computation; they might arise over evolution development. Overall, provides guiding principle informational architecture cognition.

Language: Английский

Citations

62
Spatial navigation and memory: A review of the similarities and differences relevant to brain models and age DOI Creative Commons
Arne D. Ekstrom, Paul F. Hill

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1037 - 1049

Published: April 1, 2023

Language: Английский

Citations

44
Age-related neural dedifferentiation and cognition DOI Creative Commons
Joshua D. Koen, Sabina Srokova, Michael D. Rugg

et al.

Current Opinion in Behavioral Sciences, Journal Year: 2020, Volume and Issue: 32, P. 7 - 14

Published: Feb. 3, 2020

Language: Английский

Citations

93
A Neuroimaging Signature of Cognitive Aging from Whole‐Brain Functional Connectivity DOI
Rongtao Jiang, Dustin Scheinost, Nianming Zuo

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(24)

Published: July 10, 2022

Cognitive decline is amongst one of the most commonly reported complaints during normal aging. Despite evidence that age and cognition are linked with similar neural correlates, no previous studies have directly ascertained how these two constructs overlap in brain terms neuroimaging-based prediction. Based on a long lifespan healthy cohort (CamCAN, aged 19-89 years, n = 567), it shown both cognitive function (domains spanning executive function, emotion processing, motor memory) human can be reliably predicted from unique patterns functional connectivity, models generalizable external datasets (n 533 453). Results show aging manifest decrease within-network connections (especially default mode ventral attention networks) increase between-network (somatomotor network). Whereas dorsal network an exception, which highly predictive ability but weakly correlated Further, positively weighted predicting fluid intelligence significantly mediate its association age. Together, findings offer insights into why often associated organization, indicating process dedifferentiation compensational theory.

Language: Английский

Citations

45
Autobiographical event memory and aging: older adults get the gist DOI Creative Commons
Matthew D Grilli, Signy Sheldon

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 26(12), P. 1079 - 1089

Published: Oct. 1, 2022

Language: Английский

Citations

45
25 years of neurocognitive aging theories: What have we learned? DOI Creative Commons
Ian M. McDonough, Sara A. Nolin, Kristina Visscher

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Sept. 23, 2022

The past 25 years have provided a rich discovery of at least four fundamental patterns that represent structural and functional brain aging across multiple cognitive domains. Of the many potential aging, few are ever examined simultaneously in given study, leading one to question their mutual exclusivity. Moreover, more studies emerging note failures replicate some patterns, thereby questioning universality prevalence these patterns. Although attempts been made create unifying theories incorporating age-related we propose field’s understanding has hindered due large number influential models with little crosstalk between them. We briefly review domain-general neurocognitive attempt explain them, provide examples recent challenges theories. Lastly, elaborate on improvements can be lead field comprehensive robust aging.

Language: Английский

Citations

42
The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance DOI Creative Commons
Martin J. Dahl, Shelby L. Bachman, Shubir Dutt

et al.

Nature Aging, Journal Year: 2023, Volume and Issue: 3(9), P. 1128 - 1143

Published: Aug. 31, 2023

Abstract Changes in dopaminergic neuromodulation play a key role adult memory decline. Recent research has also implicated noradrenaline shaping late-life memory. However, it is unclear whether these two neuromodulators have distinct roles age-related cognitive changes. Here, combining longitudinal MRI of the substantia nigra–ventral tegmental area (SN-VTA) and noradrenergic locus coeruleus (LC) younger ( n = 69) older 251) adults, we found that integrity are differentially associated with performance. While LC was related to better episodic across several tasks, SN-VTA linked working Longitudinally, age more negative change integrity. Notably, changes reliably predicted future These differential associations nuclei decline potential clinical utility, given their degeneration age-associated diseases.

Language: Английский

Citations

32
Brain asymmetries from mid- to late life and hemispheric brain age DOI Creative Commons
Max Korbmacher, Dennis van der Meer, Dani Beck

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 1, 2024

Abstract The human brain demonstrates structural and functional asymmetries which have implications for ageing mental neurological disease development. We used a set of magnetic resonance imaging (MRI) metrics derived from diffusion MRI data in N =48,040 UK Biobank participants to evaluate age-related differences asymmetry. Most regional grey white matter presented asymmetry, were higher later life. Informed by these results, we conducted hemispheric age (HBA) predictions left/right multimodal metrics. HBA was concordant conventional predictions, using both hemispheres, but offers supplemental general marker asymmetry when setting into relationship with each other. In contrast WM asymmetries, discrepancies are lower at ages. Our findings outline various sex-specific differences, particularly important estimates, the value further investigating role

Language: Английский

Citations

16
Demands on perceptual and mnemonic fidelity are a key determinant of age-related cognitive decline throughout the lifespan. DOI Creative Commons
Helena M. Gellersen, Jessica McMaster, Ayat Abdurahman

et al.

Journal of Experimental Psychology General, Journal Year: 2024, Volume and Issue: 153(1), P. 200 - 223

Published: Jan. 1, 2024

Aging results in less detailed memories, reflecting reduced fidelity of remembered compared to real-world representations. We tested whether poorer representational across perception, short-term memory (STM), and long-term (LTM) are among the earliest signs cognitive aging. Our paradigm probed target-lure object mnemonic discrimination precision object-location binding. Across lifespan, deficits were observed midlife when stimulus representations required for perceptual short/long-term forced choice discrimination. A continuous metric source combined with computational modeling demonstrated that errors STM LTM middle-aged adults largely driven by a loss retrieved not necessarily forgetting. On trial-by-trial basis, item spatial information was more tightly bound this association being unaffected age. Standard neuropsychological tests without demands on quality (digit span, verbal learning) sensitive age effects than precision. Perceptual predicted Neuropsychological proxies prefrontal executive functions correlated STM, but fidelity. Conversely, indicators hippocampal integrity both LTM, suggesting partially dissociable mechanisms interindividual variability These findings suggest is hallmark aging can be from onward. Continuous tasks may promising early detection subtle age-related decline. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Language: Английский

Citations

10