Motivated for near impossibility: How task type and reward modulate task enjoyment and the striatal activation for extremely difficult task DOI Creative Commons
Michiko Sakaki, Stefanie Meliß, Kou Murayama

et al.

Cognitive Affective & Behavioral Neuroscience, Journal Year: 2022, Volume and Issue: 23(1), P. 30 - 41

Published: Nov. 30, 2022

Abstract Economic and decision-making theories suppose that people would disengage from a task with near zero success probability, because this implicates little normative utility values. However, humans often are motivated for an extremely challenging task, even without any extrinsic incentives. The current study aimed to address the nature of challenge-based motivation its neural correlates. We found that, when participants played skill-based incentives, their enjoyment increased as chance decreased , if was almost impossible achieve. such not observed were rewarded or reward determined in probabilistic manner. activation ventral striatum/pallidum tracked pattern enjoyment. These results suggest intrinsically challenge nearly but only requires certain skills rewards unavailable.

Language: Английский

An experimental manipulation of the value of effort DOI
Hause Lin, Andrew Westbrook,

Frank Fan

et al.

Nature Human Behaviour, Journal Year: 2024, Volume and Issue: 8(5), P. 988 - 1000

Published: March 4, 2024

Language: Английский

Citations

16
Dopamine release in human associative striatum during reversal learning DOI Creative Commons
Filip Grill, Marc Guitart‐Masip, Jarkko Johansson

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 2, 2024

Abstract The dopaminergic system is firmly implicated in reversal learning but human measurements of dopamine release as a correlate success are lacking. Dopamine and hemodynamic brain activity response to unexpected changes action-outcome probabilities here explored using simultaneous dynamic [11C]Raclopride PET-fMRI computational modelling behavior. When participants encounter reversed reward during card guessing game, observed associative striatum. Individual differences absolute prediction error sensitivity errors associated with peak receptor occupancy. fMRI perseverance at the onset spatially overlap site release. Trial-by-trial correlates show striatum association cortices, closely overlapping location release, separable from valence signal ventral results converge implicate striatal central component learning, possibly signifying need for increased cognitive control when new stimuli-responses should be learned.

Language: Английский

Citations

11
Insights into control over cognitive flexibility from studies of task-switching DOI Creative Commons
Tobias Egner, Audrey Siqi-Liu

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 55, P. 101342 - 101342

Published: Jan. 4, 2024

Language: Английский

Citations

10
Moving, fast and slow: behavioural insights into bradykinesia in Parkinson’s disease DOI Creative Commons
Damian M. Herz, Peter Brown

Brain, Journal Year: 2023, Volume and Issue: 146(9), P. 3576 - 3586

Published: March 2, 2023

The debilitating symptoms of Parkinson's disease, including the hallmark slowness movement, termed bradykinesia, were described more than 100 years ago. Despite significant advances in elucidating genetic, molecular and neurobiological changes it remains conceptually unclear exactly why patients with disease move slowly. To address this, we summarize behavioural observations movement discuss these findings a framework optimal control. In this framework, agents optimize time takes to gather harvest rewards by adapting their vigour according reward that is at stake effort needs be expended. Thus, slow movements can favourable when deemed unappealing or very costly. While reduced sensitivity, which makes less inclined work for reward, has been reported appears related mainly motivational deficits (apathy) rather bradykinesia. Increased sensitivity proposed underlie disease. However, careful bradykinesia are inconsistent abnormal computations costs due accuracy constraints energetic expenditure. These inconsistencies resolved considering general disability switch between stable dynamic states contribute an composite cost This account paradoxical such as abnormally relaxation isometric contractions difficulties halting both increase energy A sound understanding mediating motor impairment will vital linking them underlying neural dynamics distributed brain networks grounding future experimental studies well-defined frameworks.

Language: Английский

Citations

21
The Willpower Paradox: Possible and Impossible Conceptions of Self-Control DOI Creative Commons
Thomas Goschke, Veronika Job

Perspectives on Psychological Science, Journal Year: 2023, Volume and Issue: 18(6), P. 1339 - 1367

Published: Feb. 15, 2023

Self-control denotes the ability to override current desires render behavior consistent with long-term goals. A key assumption is that self-control required when short-term are transiently stronger (more preferred) than goals and people would yield temptation without exerting self-control. We argue this widely shared conception of raises a fundamental yet rarely discussed conceptual paradox: How it possible person most strongly perform (e.g., eat chocolate) at same time recruit prevent themselves from doing it? detailed analysis reveals three common assumptions about cannot be true simultaneously. To avoid paradox, any coherent theory must abandon either (a) recruitment an intentional process, or (b) humans unitary agents, (c) consists in overriding currently strongest desire. propose taxonomy different kinds processes helps organize theories according which these they abandon. conclude by outlining unresolved questions future research perspectives raised conceptions discuss implications for question whether can considered rational.

Language: Английский

Citations

18
Striatal and Behavioral Responses to Reward Vary by Socioeconomic Status in Adolescents DOI Creative Commons
Alexandra Decker, Steven L. Meisler,

Nicholas A. Hubbard

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(11), P. e1633232023 - e1633232023

Published: Jan. 22, 2024

Disparities in socioeconomic status (SES) lead to unequal access financial and social support. These disparities are believed influence reward sensitivity, which turn hypothesized shape how individuals respond pursue rewarding experiences. However, surprisingly little is known about SES shapes sensitivity adolescence. Here, we investigated influenced adolescent responses reward, both behavior the striatum—a brain region that highly sensitive reward. We examined immediate (tracked by phasic dopamine) average rate fluctuations tonic as these distinct signals independently learning motivation. Adolescents ( n = 114; 12–14 years; 58 female) performed a gambling task during functional magnetic resonance imaging. manipulated trial-by-trial loss outcomes, leading between periods of scarcity abundance. found higher hastened behavioral responses, increased guess switching, consistent with idea abundance increases response vigor exploration. Moreover, reinforced previously decisions (win–stay, lose–switch) slowed (postreward pausing), particularly when rewards were scarce. Notably, lower-SES adolescents down less after rare than higher-SES adolescents. In brain, striatal activations covaried across time showed greater blocks. effects diminished findings show striatum tracks fluctuations, lower appears attenuate reward-driven responses.

Language: Английский

Citations

8
Aversive motivation and cognitive control DOI Creative Commons
Debbie Yee, Xiamin Leng, Amitai Shenhav

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 133, P. 104493 - 104493

Published: Dec. 12, 2021

Language: Английский

Citations

38
Neurocognitive predictors of addiction-related outcomes: A systematic review of longitudinal studies DOI Creative Commons
Erynn Christensen, Maja Brydevall, Lucy Albertella

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 152, P. 105295 - 105295

Published: June 28, 2023

It is well-established that addiction typically associated with a distinct pattern of neurocognitive functioning consensus it typified by impaired top-down executive control and aberrant risk-reward processing. Despite neurocognition plays an important role in characterizing maintaining addictive disorders, there lack systematic, bottom-up synthesis quantitative evidence showing predicts behaviors, which constructs have the best predictive validity. This systematic review aimed to assess whether cognitive processes as defined Research Domain Criteria (RDoC) predict development maintenance behaviors specifically, consumption, severity, relapse. The findings from this expose substantial for predicting outcomes. However, suggests reward-related may be detection early risk addiction, well potentially viable target designing novel, more effective interventions.

Language: Английский

Citations

17
Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review DOI Creative Commons
Agniete Kampaite,

Rebecka Gustafsson,

Elizabeth N. York

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(3), P. e0299634 - e0299634

Published: March 29, 2024

Multiple Sclerosis (MS) is an autoimmune disease affecting the central nervous system, characterised by neuroinflammation and neurodegeneration. Fatigue depression are common, debilitating, intertwined symptoms in people with relapsing-remitting MS (pwRRMS). An increased understanding of brain changes mechanisms underlying fatigue RRMS could lead to more effective interventions enhancement quality life. To elucidate relationship between connectivity pwRRMS we conducted a systematic review. Searched databases were PubMed, Web-of-Science Scopus. Inclusion criteria were: studied participants ( n ≥ 20; 18 years old) differentiated subtypes; published 2001-01-01 2023-01-18; used assessments validated for MS; included structural, functional magnetic resonance imaging (fMRI) or diffusion MRI (dMRI). Sixty studies met criteria: dMRI (15 fatigue, 5 depression) 22 fMRI (20 studies. The literature was heterogeneous; half reported no correlation measures depression. Positive findings showed that abnormal cortico-limbic structural associated linked cortico-thalamic-basal-ganglial networks. Additionally, both related altered cingulum connectivity, involving thalamus, cerebellum, frontal lobe, ventral tegmental area, striatum, default mode attention networks, supramarginal, precentral, postcentral gyri. Qualitative analysis suggests changes, possibly due axonal and/or myelin loss, network may underlie pwRRMS, respectively, but overall results inconclusive, explained heterogeneity limited number This highlights need further including advanced detect subtle association fatigue. Future using optimised protocols required clarify substrates these pwRRMS.

Language: Английский

Citations

5
Ethological computational psychiatry: Challenges and opportunities DOI Creative Commons
Ilya E. Monosov, Jan Zimmermann, Michael J. Frank

et al.

Current Opinion in Neurobiology, Journal Year: 2024, Volume and Issue: 86, P. 102881 - 102881

Published: May 1, 2024

Studying the intricacies of individual subjects' moods and cognitive processing over extended periods time presents a formidable challenge in medicine. While much systems neuroscience appropriately focuses on link between neural circuit functions well-constrained behaviors short timescales (e.g., trials, hours), many mental health conditions involve complex interactions mood cognition that are non-stationary across behavioral contexts evolve timescales. Here, we discuss opportunities, challenges, possible future directions computational psychiatry to quantify continuously monitored behaviors. We suggest this exploratory effort may contribute more precision-based approach treating disorders facilitate robust reverse translation animal species. conclude with ethical considerations for any field aims bridge artificial intelligence patient monitoring.

Language: Английский

Citations

5