Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
21, P. 313 - 323
Published: Sept. 13, 2022
Hydrogels
are
emerging
as
the
most
promising
dressings
due
to
their
excellent
biocompatibility,
extracellular
matrix
mimicking
structure,
and
drug
loading
ability.
However,
existing
hydrogel
exhibit
limited
breathability,
poor
environmental
adaptability,
potential
resistance,
options,
which
extremely
restrict
therapeutic
effect
working
scenarios.
Here,
current
research
introduces
first
paradigm
of
textile
based
on
novel
gelatin
glycerin
(glyhydrogel)
fibers
fabricated
by
Hofmeister
wet
spinning.
Benefiting
from
unique
knitted
dressing
features
breathability
(1800
times
that
commercially
available
3
M
dressing)
stretchability
(535.51
±
38.66%).
Furthermore,
glyhydrogel
can
also
withstand
extreme
temperature
-80
°C,
showing
for
application
in
subzero
environments.
Moreover,
introduction
endows
with
remarkable
antibacterial
property
expands
selection
loaded
drugs
(e.g.,
clindamycin).
The
prepared
shows
an
infected
wound
healing
a
complete
rat
skin
closure
within
14
days.
All
these
functions
have
not
been
achievable
traditional
provide
new
approach
development
dressings.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3950 - 3950
Published: Feb. 16, 2023
Our
skin
is
the
largest
organ
of
body,
serving
as
an
important
barrier
against
harsh
extrinsic
environment.
Alongside
preventing
desiccation,
chemical
damage
and
hypothermia,
this
protects
body
from
invading
pathogens
through
a
sophisticated
innate
immune
response
co-adapted
consortium
commensal
microorganisms,
collectively
termed
microbiota.
These
microorganisms
inhabit
distinct
biogeographical
regions
dictated
by
physiology.
Thus,
it
follows
that
perturbations
to
normal
homeostasis,
occurs
with
ageing,
diabetes
disease,
can
cause
microbial
dysbiosis
increase
infection
risk.
In
review,
we
discuss
emerging
concepts
in
microbiome
research,
highlighting
pertinent
links
between
cutaneous
repair.
Moreover,
address
gaps
current
knowledge
highlight
key
areas
requiring
further
exploration.
Future
advances
field
could
revolutionise
way
treat
associated
ageing
other
pathologies.
Human
skin
is
home
to
a
variety
of
commensal
bacteria,
including
many
species
coagulase-negative
staphylococci
(CoNS).
While
it
well
established
that
the
microbiota
as
whole
maintains
homeostasis
and
excludes
pathogens
(i.e.,
colonization
resistance),
relatively
little
known
about
unique
contributions
individual
CoNS
these
interactions.
Staphylococcus
hominis
second
most
frequently
isolated
from
healthy
skin,
there
emerging
evidence
suggest
may
play
an
important
role
in
excluding
pathogens,
aureus
,
colonizing
or
infecting
skin.
Pathogens,
Journal Year:
2024,
Volume and Issue:
13(4), P. 276 - 276
Published: March 24, 2024
Staphylococcus
aureus
(S.
aureus)
is
a
common
pathogen
that
can
cause
many
human
diseases,
such
as
skin
infection,
food
poisoning,
endocarditis,
and
sepsis.
These
diseases
be
minor
infections
or
life-threatening,
requiring
complex
medical
management
resulting
in
substantial
healthcare
costs.
Meanwhile,
the
critically
ignored
“organ,”
intestinal
microbiome
greatly
impacts
physiological
health,
not
only
gastrointestinal
but
also
disorders
beyond
gut.
However,
correlation
between
S.
infection
microbial
homeostasis
largely
unknown.
Here,
we
summarized
recent
progress
understanding
their
interactions
with
intestine.
summarizations
will
help
us
understand
mechanisms
behind
these
crosstalk
challenges
are
facing
now,
which
could
contribute
to
preventing
infections,
effective
treatment
investigation,
vaccine
development.
