Cell Reports,
Journal Year:
2024,
Volume and Issue:
43(4), P. 114022 - 114022
Published: April 1, 2024
Staphylococcus
aureus
causes
the
majority
of
skin
and
soft
tissue
infections,
but
this
pathogen
only
transiently
colonizes
healthy
skin.
However,
transient
exposure
enables
S.
to
transition
infection.
The
initial
adhesion
corneocytes
is
mediated
by
surface
protein
G
(SasG).
Here,
phylogenetic
analyses
reveal
presence
two
major
divergent
SasG
alleles
in
aureus:
SasG-I
SasG-II.
Structural
SasG-II
identify
a
nonaromatic
arginine
binding
pocket
lectin
subdomain
that
mediates
corneocytes.
Atomic
force
microscopy
corneocyte
assays
indicate
can
bind
broader
variety
ligands
than
SasG-I.
Glycosidase
treatment
results
different
profiles
between
on
cells.
In
addition,
SasG-mediated
recapitulated
using
differentiated
N/TERT
keratinocytes.
Our
findings
has
evolved
adhere
multiple
ligands,
conferring
distinct
advantage
during
colonization.
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(9), P. 3051 - 3076
Published: Jan. 1, 2023
This
review
offers
systematic
considerations
of
material
design
principles
and
fabrication
techniques
for
biomimetic
skin
tissue
engineering
scaffolds.
Science,
Journal Year:
2024,
Volume and Issue:
384(6699), P. 1023 - 1030
Published: May 30, 2024
Seamless
interfaces
between
electronic
devices
and
biological
tissues
stand
to
revolutionize
disease
diagnosis
treatment.
However,
biomechanical
disparities
synthetic
materials
living
present
challenges
at
bioelectrical
signal
transduction
interfaces.
We
introduce
the
active
biointegrated
electronics
(ABLE)
platform,
encompassing
capabilities
across
biogenic,
biomechanical,
properties
simultaneously.
The
biointerface,
comprising
a
bioelectronics
layout
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 16, 2024
Topical
drug
delivery
is
widely
used
in
various
diseases
because
of
the
advantages
not
passing
through
gastrointestinal
tract,
avoiding
irritation
and
hepatic
first-pass
effect,
reaching
lesion
directly
to
reduce
unnecessary
adverse
reactions.
The
skin
helps
organism
defend
itself
against
a
huge
majority
external
aggressions
one
most
important
lines
defense
body.
However,
skin’s
strong
barrier
ability
also
obstacle
effectiveness
topical
medications.
Allowing
bioactive,
composition
pass
stratum
corneum
as
needed
reach
target
site
essential
need
for
exert
its
therapeutic
effect.
state
barrier,
choice
system
composition,
individualized
disease
detection
dosing
planning
influence
Nowadays,
enhancing
transdermal
absorption
topically
applied
drugs
hottest
research
area.
first
improve
all
drugs.
Excessive
enhances
accumulation
at
non-target
sites
occurrence
This
paper
introduces
strategies
from
three
perspectives:
delivery,
describes
current
status
shortcomings
research,
provides
new
directions
ideas
research.
Abstract
Recent
advances
in
understanding
the
modulatory
functions
of
gut
and
microbiota
on
human
diseases
facilitated
our
focused
attention
contribution
to
pathophysiological
alterations
many
extraintestinal
organs,
including
liver,
heart,
brain,
lungs,
kidneys,
bone,
skin,
reproductive,
endocrine
systems.
In
this
review,
we
applied
“gut–X
axis”
concept
describe
linkages
between
other
organs
discussed
latest
findings
related
axis,”
underlying
mechanisms
potential
clinical
intervention
strategies.
Microbiology,
Journal Year:
2023,
Volume and Issue:
169(8)
Published: Aug. 3, 2023
In
Gram-positive
bacteria
such
as
Staphylococcus
aureus
and
the
coagulase-negative
staphylococci
(CoNS),
accessory
gene
regulator
(
agr
)
is
a
highly
conserved
but
polymorphic
quorum-sensing
system
involved
in
colonization,
virulence
biofilm
development.
Signalling
via
depends
on
interaction
of
an
autoinducing
peptide
(AIP)
with
AgrC,
transmembrane
sensor
kinase
that,
once
phosphorylated
activates
response
AgrA.
This
turn
autoinduces
AIP
biosynthesis
drives
target
expression
directly
AgrA
or
post-transcriptional
regulator,
RNAIII.
this
review
we
describe
molecular
mechanisms
underlying
-mediated
generation
of,
to,
AIPs
basis
AIP-dependent
activation
inhibition
AgrC.
How
environment
impacts
functionality
considered
consequences
dysfunction
for
infection
explored.
We
also
discuss
concept
AIP-driven
competitive
interference
between
S.
CoNS
its
anti-infective
potential.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Abstract
The
efficient
management
of
skin
wounds
for
rapid
and
scarless
healing
represents
a
major
clinical
unmet
need.
Nonhealing
undesired
scar
formation
impair
quality
life
result
in
high
healthcare
expenditure
worldwide.
skin-colonizing
microbiota
contributes
to
maintaining
an
intact
barrier
homeostasis,
but
it
also
participates
the
pathogenesis
many
disorders,
including
aberrant
wound
healing,
respects.
This
review
focuses
on
composition
microbiome
cutaneous
different
types
(i.e.
acute
chronic)
with
outcomes
nonhealing
hypertrophic
scarring),
mainly
based
next-generation
sequencing
analyses;
furthermore,
we
discuss
mechanistic
insights
into
host–microbe
microbe–microbe
interactions
during
healing.
Finally,
highlight
potential
therapeutic
strategies
that
target
improve
outcomes.
