Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Language: Английский

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Protection and delivery of probiotics by degraded fucoidan-chitosan nanogel-based W1/O/W2 double emulsion incorporated in self-assembled hydrogel particles

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 153, P. 109999 - 109999

Published: March 13, 2024

Language: Английский

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Recent progress in health effects and enzymatic production of epilactose, a functional lactose derivative

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 144, P. 104338 - 104338

Published: Jan. 11, 2024

Language: Английский

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Relationships between Habitual Polyphenol Consumption and Gut Microbiota in the INCLD Health Cohort

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 773 - 773

Published: March 8, 2024

While polyphenol consumption is often associated with an increased abundance of beneficial microbes and decreased opportunistic pathogens, these relationships are not completely described for polyphenols consumed via habitual diet, including culinary herb spice consumption. This analysis the International Cohort on Lifestyle Determinants Health (INCLD Health) cohort uses a dietary questionnaire 16s microbiome data to examine between gut microbiota in healthy adults (n = 96). In this exploratory analysis, microbial taxa, but diversity measures, differed by levels Taxa identified as biomarkers daily (mg/day) included Lactobacillus, Bacteroides, Enterococcus, Eubacterium ventriosum group, Ruminococcus torques Sutterella. frequency polyphenol-weighted use Lachnospiraceae UCG-001, UCG-004, Methanobrevibacter, Lachnoclostridium, Lachnotalea. Several differentiating taxa carry out activities important human health, although those previously pro-inflammatory qualities certain contexts displayed inverse Our results suggest that higher quantities may support intestinal environment where bacteria represented lower relative compared less potentially virulent qualities.

Language: Английский

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Interactions between Gut Microbiota and Natural Bioactive Polysaccharides in Metabolic Diseases: Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2838 - 2838

Published: Aug. 24, 2024

The gut microbiota constitutes a complex ecosystem, comprising trillions of microbes that have co-evolved with their host over hundreds millions years. Over the past decade, growing body knowledge has underscored intricate connections among diet, microbiota, and human health. Bioactive polysaccharides (BPs) from natural sources like medicinal plants, seaweeds, fungi diverse biological functions including antioxidant, immunoregulatory, metabolic activities. Their effects are closely tied to which metabolizes BPs into health-influencing compounds. Understanding how interact is critical for harnessing potential health benefits. This review provides an overview focusing on its role in diseases obesity, type II diabetes mellitus, non-alcoholic fatty liver disease, cardiovascular diseases. It explores basic characteristics several impact microbiota. Given significance health, we summarize these BPs, particularly terms immunoregulatory activities, blood sugar, hypolipidemic effect, thus providing valuable reference understanding benefits treating These properties make promising agents preventing comprehensive mechanisms by exert through opens new avenues developing targeted therapies improve

Language: Английский

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Bacterial extracellular vesicles in the initiation, progression and treatment of atherosclerosis

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 22, 2025

Atherosclerosis is the primary cause of cardiovascular and cerebrovascular diseases. However, current anti-atherosclerosis drugs have shown conflicting therapeutic outcomes, thereby spurring search for novel effective treatments. Recent research indicates crucial involvement oral gastrointestinal microbiota in atherosclerosis. While gut metabolites, such as choline derivatives, been extensively studied reviewed, emerging evidence suggests that bacterial extracellular vesicles (BEVs), which are membrane-derived lipid bilayers secreted by bacteria, also play a significant role this process. BEVs host-microbiota interactions remains insufficiently explored. This review aims to elucidate complex communication mediated along gut-heart axis. In review, we summarize knowledge on BEVs, with specific focus how pathogen-derived contribute promotion atherosclerosis, well from symbionts probiotics may mitigate its progression. We explore potential challenges associated engineered prevention treatment Finally, discuss benefits using atherosclerosis diagnosis treatment, propose future directions address these issues.

Language: Английский

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Dietary index for gut microbiota is associated with stroke among US adults

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The dietary index for gut microbiota was inversely associated with stroke prevalence, particularly in adults aged 30 years and above.

Language: Английский

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Gut microbiota: A bridge between depression and cardiovascular disease-A narrative review

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100292 - 100292

Published: March 1, 2025

Language: Английский

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Lactobacillus gasseriCKCC1913 mediated modulation of the gut–liver axis alleviated insulin resistance and liver damage induced by type 2 diabetes

Food & Function, Journal Year: 2023, Volume and Issue: 14(18), P. 8504 - 8520

Published: Jan. 1, 2023

Lactobacillus gasseri CKCC1913 regulated lipid metabolism and alleviated liver damage induced by type 2 diabetes in mice.

Language: Английский

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Role of Gut Microbial Metabolites in Cardiovascular Diseases—Current Insights and the Road Ahead

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10208 - 10208

Published: Sept. 23, 2024

Cardiovascular diseases (CVDs) are the leading cause of premature morbidity and mortality globally. The identification novel risk factors contributing to CVD onset progression has enabled an improved understanding pathophysiology. In addition conventional like high blood pressure, diabetes, obesity smoking, role gut microbiome intestinal microbe-derived metabolites in maintaining cardiovascular health gained recent attention field human gastrointestinal tract caters a highly diverse spectrum microbes recognized as microbiota, which central several physiologically significant cascades such metabolism, nutrient absorption, energy balance. manipulation microbial subtleties potentially contributes CVD, inflammation, neurodegeneration, obesity, diabetic onset. existing paradigm studies suggests that disruption dynamics towards incidence. However, exact mechanistic correlation from signaling perspective remains elusive. This review focused upon in-depth characterization their varied pathophysiological conditions, highlights potential molecular mechanisms governing CVDs. addition, it summarizes courses therapy modulating its metabolites, limitations scientific gaps our current understanding, well future directions involving modulation can be undertaken develop CVD-associated treatment options. Clarity interaction(s) associations shall enable development druggable targets ameliorate years come.

Language: Английский

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