The skin barrier and microbiome in infantile atopic dermatitis development: can skincare prevent onset? DOI Creative Commons
Tomoka Ito, Yuumi Nakamura

International Immunology, Journal Year: 2024, Volume and Issue: 36(11), P. 579 - 584

Published: June 18, 2024

Atopic dermatitis (AD), a prevalent Th2-dominant skin disease, involves complex genetic and environmental factors, including mutations in the Filaggrin gene dysbiosis of microbiota characterized by an increased abundance Staphylococcus aureus. Our recent findings emphasize pivotal role barrier's integrity microbial composition infantile AD allergic diseases. Early predisposes infants to AD, suggesting targeted skincare practices as preventive strategy. The effects interventions, particularly application moisturizers with appropriate molar concentration ceramides, cholesterol, fatty acids, play crucial restoring barrier. Notably, our study revealed that can reduce Streptococcus while supporting Cutibacterium acnes presence, thus directly linking modulation neonatal skin. Despite mixed outcomes previous Randomized Controlled Trials on efficacy prevention, research points potential intervention primary method against minimizing impact factors. Furthermore, supports notion early aggressive management eczema may incidence food allergies, highlighting necessity for multifaceted prevention strategies address both barrier immune sensitization. By focusing repairing adjusting skin's microbiome from birth, we propose novel perspective preventing diseases, opening new avenues future studies, allergy prevention.

Language: Английский

Microenvironmental host–microbe interactions in chronic inflammatory skin diseases DOI Creative Commons
Lene Bay, Gregor B. E. Jemec, Hans Christian Ring

et al.

Apmis, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Several microbiome studies have recently demonstrated microbial dysbiosis in various chronic inflammatory skin diseases, and it is considered an important role the pathogenesis. Although of diseases debatable, local microenvironment essential concerning compositional changes functional alterations microbiota. Indeed, nutrients (e.g., lipids), pH values, water, oxygen, antimicrobial peptides may affect level these diseases. In particular, atopic dermatitis hidradenitis suppurativa, significant been associated with aberrant host immune changes. this review, potential pathogenic crosstalk between microbiota reviewed relation to physical, chemical, biological microenvironments

Language: Английский

Citations

2
Invasive Staphylococcus epidermidis uses a unique processive wall teichoic acid glycosyltransferase to evade immune recognition DOI Creative Commons
Yinglan Guo, Xin Du, Janes Krusche

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(47)

Published: Nov. 24, 2023

Staphylococcus epidermidis expresses glycerol phosphate wall teichoic acid (WTA), but some health care–associated methicillin-resistant S. (HA-MRSE) clones produce a second, ribitol (RboP) WTA, resembling that of the aggressive pathogen aureus . RboP-WTA promotes HA-MRSE persistence and virulence in bloodstream infections. We report here TarM enzyme [TarM(Se)] glycosylates with glucose, instead N -acetylglucosamine (GlcNAc) by TarM(Sa) Replacement GlcNAc glucose impairs detection human immunoglobulin G, which may contribute to immune-evasion capacities many invasive Crystal structures complexes uridine diphosphate (UDP-glucose), UDP glycosylated poly(RboP), reveal binding mode glycosylation mechanism this explain why TarM(Se) link different sugars poly(RboP). These structural data provide evidence is processive WTA glycosyltransferase. Our study will support targeted inhibition enzymes, development targeting vaccines phage therapies.

Language: Английский

Citations

5
Living, quiescent Lactobacillus plantarum Lp90 probiotic, delivered topically to full thickness tissues in vitro via a just‐add‐water cream delivery system, stimulates the expression of elastin protein DOI Creative Commons
James V. Gruber, Robert Holtz

Journal of Cosmetic Dermatology, Journal Year: 2023, Volume and Issue: 22(10), P. 2852 - 2860

Published: July 20, 2023

Delivering living probiotics to the skin can be challenging as most water-containing cosmetic products require preservatives maintain product stability. A recently introduced powdered technology [Stratabiosys™, Vantage Personal Care] allows for quiescent probiotic powders stored extended periods of time. The then reconstituted creams at point use by adding water and mixing were examined in vitro on reconstructed human full thickness tissues see if had any influence several important biomolecules expressed skin.A powder containing 200 M CFU/gram Lactobacillus plantarum Lp90 was a cream ultrapure gently components room temperature quickly produce cream. resulting tested topically Epiderm® Full Thickness Tissues treating 24 h, removing with PBS rinse repeating treatment another h. four strategically including Type 1A collagen, elastin, filaggrin hyaluronic acid. probiotic-containing against untreated not measured amounts one two cryoprotectants known used integrity during drying powders.It found that topical 2 (1%), 4 (2%) 6 (3%) prepared from base stimulated elastin expression dose dependent fashion. There no effect other studies. In addition, it made only cryoprotectants, bacteria, expression.The results this study demonstrate delivery is possible converted just prior application tissues. case Lp90, significantly increased replicants after 48 h exposure probiotic. elastin-stimulating effects are coming oligosaccharide their quiescent, dried state. indicate stimulating

Language: Английский

Citations

4
From gut to skin: exploring the potential of natural products targeting microorganisms for atopic dermatitis treatment DOI
Hang Zhao, Xin Ma, Jiankun Song

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 14(17), P. 7825 - 7852

Published: Jan. 1, 2023

Under the action of natural products, microorganisms participate in a complete cycle “gut-brain-skin” axis linkage mechanism, thereby regulating development atopic dermatitis.

Language: Английский

Citations

4
Microbiome in Atopic Dermatitis: Is It All About Staphylococcus aureus? DOI
Cristina Gómez‐Casado,

Zsófia Unger,

Péter Oláh

et al.

Current Treatment Options in Allergy, Journal Year: 2023, Volume and Issue: 10(4), P. 351 - 363

Published: Sept. 29, 2023

Language: Английский

Citations

4
Proteolytic and Antiproteolytic Activity in the Skin: Gluing the Pieces Together DOI Creative Commons
A. Peled, Eli Sprecher

Journal of Investigative Dermatology, Journal Year: 2023, Volume and Issue: 144(3), P. 466 - 473

Published: Oct. 20, 2023

Language: Английский

Citations

4
The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis DOI Creative Commons
Junchao Wu, Lisha Li, Tingrui Zhang

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

The promotion of epidermal barrier dysfunction is attributed to abnormalities in the lipid-microbiome positive feedback loop which significantly influences imbalance epithelial immune microenvironment (EIME) atopic dermatitis (AD). This encompasses impaired lamellar membrane integrity, heightened exposure pathogens, and regulation innate adaptive immunity. substantially influenced by intense immunity triggered abnormal activity affects loop's integrity through induction atypical lipid composition responses dysregulated microbes. Immune participate within EIME downregulating gene expression are further cascade-amplified microbial dysregulation instigated impairment. review examines relationship between composition, microbiome disturbances, AD while progressively substantiating crosstalk mechanism among these factors. Based on this analysis, "lipid-microbiome" loop, regulated responses, proposed. delves into impact that regulate EIME, driving AD, investigates potential mechanisms supplementation probiotics may alleviate up-regulation modulation signaling. exploration offers support for targeting attenuate AD.

Language: Английский

Citations

1
Lipid analysis of human primary dermal fibroblasts and epidermal keratinocytes after near-infrared exposure using mass spectrometry imaging DOI Creative Commons
Laura van der Vloet,

Zoé Ducarne,

Ron M. A. Heeren

et al.

Journal of Biotechnology, Journal Year: 2024, Volume and Issue: 396, P. 53 - 61

Published: Oct. 18, 2024

Language: Английский

Citations

1
Multi‐omics analysis to evaluate the effects of solar exposure and a broad‐spectrum SPF50+ sunscreen on markers of skin barrier function in a skin ecosystem model DOI
Carine Jacques, Emilien L. Jamin,

Anais Noustens

et al.

Photochemistry and Photobiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

Abstract Sun exposure induces major skin alterations, but its effects on metabolites and lipids remain largely unknown. Using an original reconstructed human epidermis (RHE) model colonized with microbiota supplemented sebum, we previously showed that a single dose of simulated solar radiation (SSR) significantly impacted the metabolome microbiota. In this article, further analyzed SSR‐induced changes in same RHE model. Among altered (log2‐fold p ≤ 0.05), found several natural moisturizing factors (NMFs): amino acids, lactate, glycerol, urocanic acid, pyrrolidone carboxylic acid derivatives. Analyses stratum corneum also SSR induced lower levels free fatty acids higher ceramides, cholesterols An imbalance NMFs ceramides combined to increase proinflammatory may participate permeability barrier impairment, dehydration inflammatory reaction sun. Our allowed evaluation innovative ultraviolet/blue light (UV/BL) broad‐spectrum sunscreen high sun protection factor (SPF50+). We using prior could part prevent alterations ecosystem

Language: Английский

Citations

0
Large-scale investigation for antimicrobial activity reveals novel defensive species across the healthy skin microbiome DOI Creative Commons

Uyen Thy Nguyen,

Rauf Salamzade, Shelby Sandstrom

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

The human skin microbiome constitutes a dynamic barrier that can impede pathogen invasion by producing antimicrobial natural products. Gene clusters encoding for production of secondary metabolites, biosynthetic gene (BGCs), are enriched in the relative to other ecological settings, position this niche as promising source new product mining. Here, we introduce isolate collection, EPithelial Isolate Collection (EPIC). It includes large phylogenetically diverse set skin-derived bacterial strains from eight body sites. This consisting 980 is larger and more than existing resources, hundreds rare low-abundance species, unique BGCs. Using large-scale co-culture screen assess 8,756 pairwise interactions between skin-associated bacteria potential pathogens, reveal broad antifungal activity members. Integrating 287 whole genomes 268 metagenomes sampling sites demonstrates while distribution BGC types stable across sites, specific cluster families (GCFs), each predicted encode distinct metabolite, substantially vary. Sites dry or rarely moist harbor greatest discovery novel bioactive metabolites. Among our discoveries four three which exert significant broad-spectrum activity. comprehensive collection advances understanding microbiomes capabilities pathogen-fighting mechanisms, opening avenues towards drug engineering.

Language: Английский

Citations

0