Cambridge Quarterly of Healthcare Ethics,
Journal Year:
2023,
Volume and Issue:
32(4), P. 582 - 596
Published: June 8, 2023
Human
brain
organoids
(HBOs)
are
three-dimensional
biological
entities
grown
in
the
laboratory
order
to
recapitulate
structure
and
functions
of
adult
human
brain.
They
can
be
taken
novel
living
for
their
specific
features
uses.
As
a
contribution
ongoing
discussion
on
use
HBOs,
authors
identify
three
sets
reasons
moral
concern.
The
first
set
regards
potential
emergence
sentience/consciousness
HBOs
that
would
endow
them
with
status
whose
perimeter
should
established.
second
concerns
has
do
an
analogy
artificial
womb
technology.
technical
realization
processes
typically
connected
physiology
body
create
manipulatory
instrumental
attitude
undermine
protection
what
is
human.
third
new
frontiers
biocomputing
creation
chimeras.
far
as
frontier
organoid
intelligence
concerned,
it
close
relationship
humans
interfaces
having
components
capable
mimicking
memory
cognition
raises
ethical
issues.
chimeras
humanization
nonhuman
animals
worthy
scrutiny.
A
detailed
description
these
issues
provided
contribute
construction
regulative
framework
guide
decisions
when
considering
research
field
HBOs.
Neuroscience of Consciousness,
Journal Year:
2021,
Volume and Issue:
2021(2)
Published: Jan. 1, 2021
Over
the
last
years,
a
surge
of
empirical
studies
converged
on
complexity-related
measures
as
reliable
markers
consciousness
across
many
different
conditions,
such
sleep,
anesthesia,
hallucinatory
states,
coma,
and
related
disorders.
Most
these
were
independently
proposed
by
researchers
endorsing
disparate
frameworks
employing
methods
techniques.
Since
this
body
evidence
has
not
been
systematically
reviewed
coherently
organized
so
far,
positive
trend
remained
somewhat
below
radar.
The
aim
paper
is
to
make
consilience
in
science
explicit.
We
start
with
systematic
assessment
growing
literature
identify
their
common
denominator,
tracing
it
back
core
theoretical
principles
predictions
put
forward
more
than
20
years
ago.
In
doing
this,
we
highlight
consistent
trajectory
spanning
two
decades
research
provide
provisional
taxonomy
present
literature.
Finally,
consider
all
above
ground
approach
new
questions
devise
future
experiments
that
may
help
consolidate
further
develop
promising
field
where
appears
have,
naturally
converged.
Stem Cell Research & Therapy,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: July 23, 2022
Abstract
Organoids
are
3D
structures
grown
from
pluripotent
stem
cells
derived
human
tissue
and
serve
as
in
vitro
miniature
models
of
organs.
expected
to
revolutionize
biomedical
research
clinical
care.
However,
organoids
not
seen
morally
neutral.
For
instance,
donors
may
perceive
enduring
personal
connections
with
their
organoids,
setting
higher
bars
for
informed
consent
patient
participation.
Also,
several
organoid
sub-types,
e.g.,
brain
human–animal
chimeric
have
raised
controversy.
This
systematic
review
provides
an
overview
ethical
discussions
conducted
the
scientific
literature
on
organoids.
The
covers
both
applications
technology
discusses
topics
consent,
commercialization,
personalized
medicine,
transplantation,
chimeras,
gastruloids.
It
shows
that
further
is
needed
especially
help
ensure
responsible
development
implementation
this
field.
Trends in Cognitive Sciences,
Journal Year:
2024,
Volume and Issue:
28(5), P. 454 - 466
Published: March 13, 2024
Which
systems/organisms
are
conscious?
New
tests
for
consciousness
('C-tests')
urgently
needed.
There
is
persisting
uncertainty
about
when
arises
in
human
development,
it
lost
due
to
neurological
disorders
and
brain
injury,
how
distributed
nonhuman
species.
This
need
amplified
by
recent
rapid
developments
artificial
intelligence
(AI),
neural
organoids,
xenobot
technology.
Although
a
number
of
C-tests
have
been
proposed
years,
most
limited
use,
currently
we
no
many
the
populations
which
they
critical.
Here,
identify
challenges
facing
any
attempt
develop
C-tests,
propose
multidimensional
classification
such
tests,
strategies
that
might
be
used
validate
them.
The MIT Press eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 6, 2024
An
engaging
and
insightful
journey
into
human
consciousness.
What
if
our
goal
had
not
been
to
land
on
Mars,
but
in
pure
consciousness?
The
experience
of
consciousness—what
does
it
look
like?
is
the
essence
In
Elephant
Blind,
influential
philosopher
Thomas
Metzinger,
one
world's
leading
researchers
consciousness,
brings
together
more
than
500
experiential
reports
offer
first
comprehensive
account
states
Drawing
a
large
psychometric
study
meditators
57
countries,
Metzinger
focuses
“pure
awareness”
meditation—the
simplest
form
there
is—to
illuminate
most
fundamental
aspects
how
brain,
illusions
self
all
interact.
Starting
with
an
exploration
existential
ease
ending
Bewusstseinskultur,
culture
explores
increasingly
non-egoic
experiences
silence,
wakefulness,
clarity,
bodiless
body-experience,
ego-dissolution,
nondual
awareness.
From
there,
he
assembles
big
picture—the
elephant
parable,
from
which
book's
title
comes—of
what
would
take
arrive
at
minimal
model
explanation
for
conscious
create
genuine
Freeing
awareness
new-age
gurus
old
religions,
Blind
combines
personal
consciousness
incisive
analysis
address
whole
community,
neuroscientists
artists,
its
accessibility
echoes
author's
career-long
commitment
widening
access
philosophy
itself.
Frontiers in Psychology,
Journal Year:
2020,
Volume and Issue:
11
Published: Feb. 14, 2020
Visual
functions
are
reviewed
that
coincide
with
conscious
as
opposed
to
unconscious
vision.
Four
stages
of
vision
identified,
going
from
the
fully
invisible,
subjectively
unattended
and
clearly
visible.
It
is
proposed
feature
extraction,
categorization
some
aspects
visual
inference
occur
during
full
subjective
invisibility.
Functions
related
perceptual
organization,
such
grouping
figure-ground
segregation
inattention
well
visibility.
argued
organization
function
central
understanding
transition
seeing.
discussed
what
this
implies
for
theories
consciousness
Recurrent
Processing
Theory,
Higher
Order
Thought
Integrated
Information
Theory
Global
Neuronal
Workspace
Theory.
Philosophy and the Mind Sciences,
Journal Year:
2020,
Volume and Issue:
1(II)
Published: Dec. 30, 2020
The
search
for
the
neural
correlates
of
consciousness
is
in
need
a
systematic,
principled
foundation
that
can
endow
putative
with
greater
predictive
and
explanatory
value.
Here,
we
propose
processing
framework
brain
function
as
promising
candidate
providing
this
systematic
foundation.
proposal
motivated
by
framework’s
ability
to
address
three
general
challenges
identifying
consciousness,
satisfy
two
constraints
common
many
theories
consciousness.
Implementing
through
lens
delivers
strong
potential
value
detailed,
mappings
between
substrates
phenomenological
structure.
We
conclude
framework,
precisely
because
it
at
outset
not
itself
theory
has
significant
advancing
neuroscience
Bioethics News,
Journal Year:
2020,
Volume and Issue:
38(2), P. 105 - 128
Published: Sept. 7, 2020
Human
cerebral
organoids
(HCOs)
are
three-dimensional
in
vitro
cell
cultures
that
mimic
the
developmental
process
and
organization
of
developing
human
brain.
In
just
a
few
years
this
technique
has
produced
brain
models
already
being
used
to
study
diseases
nervous
system
test
treatments
drugs.
Currently,
HCOs
consist
tens
millions
cells
have
size
millimeters.
The
greatest
limitation
further
development
is
due
their
lack
vascularization.
However,
recent
research
shown
can
manifest
same
electrical
activity
connections
between
neurons
EEG
patterns
as
those
recorded
preterm
babies.
All
suggests
that,
future,
may
an
ability
experience
basic
sensations
such
pain,
therefore
manifesting
sentience,
or
even
rudimentary
forms
consciousness.
This
calls
for
consideration
whether
should
be
given
moral
status
what
limitations
introduced
regulate
research.
article
I
focus
particularly
on
emergence
mechanisms
consciousness,
i.e.
one
most
complex
scientific
problems
there
are,
by
means
experiments
HCOs.
type
experiment
raises
relevant
ethical
issues
and,
will
argue,
probably
not
considered
morally
acceptable.
AJOB Neuroscience,
Journal Year:
2021,
Volume and Issue:
13(2), P. 81 - 94
Published: March 26, 2021
In
2008,
researchers
created
human
three-dimensional
neural
tissue
-
known
as
the
pioneering
work
of
"brain
organoids."
recent
years,
some
have
transplanted
brain
organoids
into
animal
brains
for
applicational
purposes.
With
these
experiments
come
many
ethical
concerns.
It
is
thus
an
urgent
task
to
clarify
what
ethically
permissible
and
impermissible
in
organoid
research.
This
paper
seeks
(1)
sort
out
issues
related
research
application
(2)
propose
future
directions
additional
consideration
policy
debates
field.
Toward
(1),
this
first
outlines
current
state
research,
then
briefly
responds
previously
raised
Looking
next
at
anticipated
scientific
developments
we
will
discuss
(i)
vitro
organoids,
(ii)
when
form
complexes
or
relationships
with
other
entities,
(iii)
ethics
governance.
Finally,
pursuit
(2),
policies
that
are
mindful
also
suggest
need
international
framework
organoids.