Tubastatin A potently inhibits GPX4 activity to potentiate cancer radiotherapy through boosting ferroptosis DOI Creative Commons
Shan Liu,

Hai‐Liang Zhang,

Jing Li

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 62, P. 102677 - 102677

Published: March 17, 2023

Ferroptosis, an iron-dependent lipid peroxidation-driven programmed cell death, is closely related to cancer therapy. The development of druggable ferroptosis inducers and their rational application in therapy are critical. Here, we identified Tubastatin A, HDAC6 inhibitor as a novel inducer through large-scale drug screening. A directly bonded GPX4 inhibited enzymatic activity biotin-linked putdown LC/MS analysis, which independent its inhibition HDAC6. In addition, our results showed that radiotherapy not only activated Nrf2-mediated transcription but also lysosome-mediated degradation, subsequently inducing tolerance radioresistance cells. overcame resistance cells by inhibiting activity. More importantly, has excellent bioavailability, demonstrated ability significantly promote radiotherapy-induced peroxidation tumour suppression mouse xenograft model. Our findings identify inducer, enhances radiotherapy-mediated antitumor effects. This work provides compelling rationale for the clinical evaluation especially combination with radiotherapy.

Language: Английский

Radiotherapy combined with immunotherapy: the dawn of cancer treatment DOI Creative Commons

Zengfu Zhang,

Xu Liu,

Dawei Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: July 29, 2022

Abstract Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic effect on remote and non-irradiated tumor deposits, which called abscopal effect. The view RT as a simple treatment has dramatically changed in recent years, it now widely accepted that provoke immune response gives strong rationale the combination immunotherapy (iRT). Nevertheless, several points remain to be addressed such interaction system, identification best schedules with (IO), expansion mechanism amplify iRT. To answer these crucial questions, we roundly summarize underlying showing whole landscape clinical trials attempt identify In consideration rarity effect, propose occurrence induced by radiation promoted 100% molecular genetic level. Furthermore, “radscopal effect” refers using low-dose reprogram microenvironment may overcome resistance Taken together, could regarded trigger antitumor response, help IO used radical added into current standard regimen patients metastatic cancer.

Language: Английский

Citations

359
X-ray-activated nanosystems for theranostic applications DOI
Xiaofeng Chen, Jibin Song, Xiaoyuan Chen

et al.

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(11), P. 3073 - 3101

Published: Jan. 1, 2019

X-rays are widely applied in clinical medical facilities for radiotherapy (RT) and biomedical imaging. However, the sole use of cancer treatment leads to insufficient radiation energy deposition due low X-ray attenuation coefficients living tissues organs, producing unavoidable excessive doses with serious side effects healthy body parts. Over past decade, developments materials science nanotechnology have led rapid progress field X-ray-activated tumor-targeting nanosystems, which able tackle even systemic tumors relieve burden exposure large doses. Additionally, novel imaging contrast agents techniques also been developed. In comparison conventional external light sources (e.g., near infrared), technique is ideal activation nanosystems applications its nearly unlimited penetration depth organisms. this review, we systematically describe interaction mechanisms between provide an overview X-ray-sensitive recent on cancer-associated theranostic applications.

Language: Английский

Citations

319
<p>The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy</p> DOI Open Access
Yue‐Chen Zhao, Yanqing Li, Ruifeng Zhang

et al.

OncoTargets and Therapy, Journal Year: 2020, Volume and Issue: Volume 13, P. 5429 - 5441

Published: June 1, 2020

Abstract: Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RAS V12 later widely investigated an inducer of ferroptosis. Ferroptosis is recently form cell death caused by peroxidation induced the accumulation intracellular lipid reactive oxygen species (L-ROS) in iron-dependent manner. can mediate ferroptosis through variety molecules including cystine-glutamate transport receptor (system X C − ), voltage-dependent anion channel (VDAC), p53. able to enhance sensitivity chemotherapy radiotherapy, suggesting promising future cancer therapy. We hope this review will help better understand role erastin lay foundation for further research development erastin-based therapies future. Keywords: erastin, ferroptosis, system , p53, VDAC,

Language: Английский

Citations

316
Immunological impact of cell death signaling driven by radiation on the tumor microenvironment DOI
María E. Rodríguez-Ruiz, Ilio Vitale, Kevin J. Harrington

et al.

Nature Immunology, Journal Year: 2019, Volume and Issue: 21(2), P. 120 - 134

Published: Dec. 23, 2019

Language: Английский

Citations

299
Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging DOI
Jiang Ouyang,

Angel Xie,

Jun Zhou

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 4996 - 5041

Published: Jan. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Language: Английский

Citations

285
Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment DOI
Chenyang Zhang, Xin Wang, Jiangfeng Du

et al.

Advanced Science, Journal Year: 2020, Volume and Issue: 8(3)

Published: Dec. 20, 2020

Abstract Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving topics ROS‐regulating therapy such as antioxidant triggered by scavengers ROS‐induced toxic mediated ROS‐elevation agents. Benefiting from remarkable advances nanotechnology, a large number nanomaterials with ability are developed to seek new effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements been made ROS‐based nanomedicines treatments, some fundamental but key questions rational design principle held low regard. Here, can serve initial framework scientists technicians optimize nanomedicines, thereby minimizing gap biomedical application during stage. Herein, overview current progress ROS‐associated is summarized. And then, particularly addressing these known strategies therapy, several principles presented. Finally, future perspectives also discussed depth development

Language: Английский

Citations

271
Applications of Noble Metal-Based Nanoparticles in Medicine DOI Open Access
Bartosz Klębowski,

Joanna Depciuch,

Magdalena Parlińska‐Wojtan

et al.

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(12), P. 4031 - 4031

Published: Dec. 13, 2018

Nanoparticles have unique, size-dependent properties, which means they are widely used in various branches of industry. The ability to control the properties nanoparticles makes these nanomaterials very interesting for medicine and pharmacology. application is associated with design specific nanostructures, can be as novel diagnostic therapeutic modalities. There a lot applications nanoparticles, e.g., drug delivery systems, radiosensitizers radiation or proton therapy, bioimaging, bactericides/fungicides. This paper aims introduce characteristics noble metal-based particular emphasis on their related sciences.

Language: Английский

Citations

243
Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers DOI
Amy M. Buckley, Niamh Lynam‐Lennon, Hazel O’Neill

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2020, Volume and Issue: 17(5), P. 298 - 313

Published: Jan. 31, 2020

Language: Английский

Citations

212
Molecular targets of β-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: A review DOI Creative Commons

Bingtao Zhai,

Nana Zhang,

Xuemeng Han

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2019, Volume and Issue: 114, P. 108812 - 108812

Published: April 6, 2019

β-Elemene is a sesquiterpene compound extracted from the herb Curcuma Rhizoma and used in traditional Chinese medicine (TCM) to treat several types of cancer, with no reported severe adverse effects. Recent studies, using vitro vivo studies combined molecular methods, have shown that β-elemene can inhibit cell proliferation, arrest cycle, induce apoptosis. identified targets may role cancer therapy. This review aims discuss anticancer potential through its actions on including kinase enzymes, transcription factors, growth factors their receptors, proteins. also regulates expression key molecules are involved tumor angiogenesis metastasis vascular endothelial factor (VEGF), matrix metalloproteinases (MMPs), E-cadherin, N-cadherin, vimentin. Also, has been regulatory effects immune response increases sensitivity cells chemoradiotherapy multidrug resistance (MDR) malignancy. autophagy, which prevents undergoing Therefore, mechanisms for treatment herbal extract, β-elemene, centuries medicine, now being studied identified.

Language: Английский

Citations

209
Engineering Radiosensitizer‐Based Metal‐Phenolic Networks Potentiate STING Pathway Activation for Advanced Radiotherapy DOI
Jie Yan, Guohao Wang, Lisi Xie

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(10)

Published: Dec. 29, 2021

Radiotherapy, a mainstay of first-line cancer treatment, suffers from its high-dose radiation-induced systemic toxicity and radioresistance caused by the immunosuppressive tumor microenvironment. The synergy between radiosensitization immunomodulation may overcome these obstacles for advanced radiotherapy. Here, authors propose cooperated with stimulator interferon genes (STING) pathway activation strategy fabricating novel lanthanide-doped radiosensitizer-based metal-phenolic network, NaGdF4 :Nd@NaLuF4 @PEG-polyphenol/Mn (DSPM). amphiphilic PEG-polyphenol successfully coordinates (radiosensitizer) Mn2+ via robust coordination. After cell internalization, pH-responsive disassembly DSPM triggers release their payloads, wherein radiosensitizer sensitizes cells to X-ray promote STING activation. This remarkably benefits dendritic maturation, anticancer therapeutics in primary tumors, accompanied immune therapeutic performance against metastatic tumors. Therefore, powerful mediated immunostimulation is highlighted here optimize

Language: Английский

Citations

184