Bisphenol A and selenium deficiency exposure induces pyroptosis and myogenic differentiation disorder in chicken muscle stomach DOI Creative Commons
Di Wu, Yingying Su, Guanghui Hu

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(6), P. 103641 - 103641

Published: March 14, 2024

Bisphenol A (BPA), which is commonly found in the environment due to its release from use of plastics and food overpacks, has become a major stressor for environmental sustainability livestock poultry farming health. Selenium (Se) deficiency causes structural damage inflammatory responses digestive system muscle tissue, there potential concurrent space-time exposure nutritional diseases toxicants poultry. The mechanisms chicken muscular stomach BPA or/and Se treatment are still not known. Here, we established model (20 mg/kg) (0.039 exposure, detected histopathological changes levels iNOS/NO pathway, IL-6/JAK/STAT3 pyroptosis, myogenic differentiation by H&E staining, immunofluorescence real-time quantitative PCR, western blot methods. data revealed that or caused gaps between fibers with cell infiltration; up-regulation pathway pathway; NLRP3/Caspase-1-dependent pyroptosis related genes; down-regulation muscle-forming (MyoD, MyoG, MyHC) genes. combination was associated higher toxic impairment than alone exposure. In conclusion, discovered myogastric disorder. These findings provide theoretical basis co-occurrence animal toxicant exposures farming, may important insights into limiting production harmful substances.

Language: Английский

Optimum Doses and Forms of Selenium Maintaining Reproductive Health via Regulating Homeostasis of Gut Microbiota and Testicular Redox, Inflammation, Cell Proliferation, and Apoptosis in Roosters DOI Creative Commons

Yiqin Yan,

Meng Liu,

Ze-Jing Xu

et al.

Journal of Nutrition, Journal Year: 2023, Volume and Issue: 154(2), P. 369 - 380

Published: Dec. 19, 2023

Language: Английский

Citations

25
Tannic acid extracted from gallnut improves intestinal health with regulation of redox homeostasis and gut microbiota of weaned piglets DOI Creative Commons

Zhang‐Chao Deng,

Jie Wang, Juan Wang

et al.

Animal Research and One Health, Journal Year: 2024, Volume and Issue: 2(1), P. 16 - 27

Published: Feb. 1, 2024

Abstract The objective of this study is to evaluate the effects tannic acid (TA) derived from gallnut supplementation on growth performance and health status weaned piglets. A total 432 weanling piglets (7.05 ± 1.05 kg) were randomly allocated into 4 treatment groups with 6 replicates 18 pigs/pen. Piglets fed either a basal diet (CON), or diets supplemented 1.5 kg/t TA, 3.0 1.8 zinc oxide (ZnO) for 21 days. results showed that, compared CON, dietary TA did not affect ( p > 0.05) serum biochemistry However, had higher SOD, GPX, CAT activities lower MDA concentration in jejunum than those CON ZnO group. Meanwhile, increased < villus height height/crypt depth, decreased crypt depth small intestine. Dietary also downregulated IL‐1β TNF‐α expression jejunum. Furthermore, reduced abundance Candidatus Brocadia Escherichia‐Shigella cecal digesta. Notably, both negative correlation antioxidant enzymes R −0.60, 0.01), but was positively correlated concentrations = 0.44, In conclusion, improved gut piglets, potentially by regulating redox homeostasis microbiota.

Language: Английский

Citations

17
Selenomethionine alleviates chronic heat stress-induced breast muscle injury and poor meat quality in broilers via relieving mitochondrial dysfunction and endoplasmic reticulum stress DOI Creative Commons
Jinzhong Jing, Jiayi Wang,

Xiaoyu Xiang

et al.

Animal nutrition, Journal Year: 2024, Volume and Issue: 16, P. 363 - 375

Published: Feb. 2, 2024

In the present study, chronic heat stress (CHS) broiler model was developed to investigate potential protection mechanism of organic selenium (selenomethionine, SeMet) on CHS-induced skeletal muscle growth retardation and poor meat quality. Four hundred Arbor Acres male broilers (680 ± 70 g, 21 d old) were grouped into 5 treatments with 8 replicates 10 per replicate. Broilers in control group raised a thermoneutral environment (22 2 °C) fed basal diet. The other four exposed hyperthermic conditions (33 °C, 24 h each day) diet supplied SeMet at 0.0, 0.2, 0.4, 0.6 mg Se/kg, respectively, for d. Results showed that CHS reduced (P < 0.05) performance, decreased breast weight impaired quality broilers. induced protein metabolic disorder muscle, which increased expression caspase 3, 8, 9 ubiquitin proteasome system related genes, while P-4EBP1. also antioxidant capacity mitochondrial endoplasmic reticulum (ER) ROS levels, concentration ATP, HSP60 CLPX, ER biomarkers. Dietary supplementation linearly Se exhibited protective effects via up-regulating selenotranscriptome several key selenoproteins, body weight, improved quality, enhanced mitigated stress. What's more, suppressed degradation biosynthesis though inhibiting promoting mTOR-4EBP1 pathway. conclusion, dietary increases alleviates dysfunction stress, improves biosynthesis, suppresses degradation, thus CHS.

Language: Английский

Citations

9
Heat Stress Impairs Male Reproductive System with Potential Disruption of Retinol Metabolism and Microbial Balance in the Testis of Mice DOI Creative Commons
Kexin Cao,

Zhang‐Chao Deng,

Meng Liu

et al.

Journal of Nutrition, Journal Year: 2023, Volume and Issue: 153(12), P. 3373 - 3381

Published: Nov. 1, 2023

Language: Английский

Citations

15
Heterotrophic Selenium Incorporation into Chlorella vulgaris K-01: Selenium Tolerance, Assimilation, and Removal through Microalgal Cells DOI Creative Commons
Zhenyu Zhang, Yan Zhang,

Yanying Hua

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(3), P. 405 - 405

Published: Jan. 26, 2024

Chlorella has been applied in the production of selenium (Se) enriched organic biomass. However, limited information exists regarding heterotrophic tolerance and its incorporation into Chlorella. This study aimed to investigate potential using vulgaris K-01 for biotransformation. To assess dose-response effect Se stress on strain, time-series growth curves were recorded, productivity parameters calculated, Gaussian process (GP) regression analysis was performed. The strain’s carbon energy metabolism evaluated by measuring residual glucose medium. Characterization different forms intracellular medium conducted inductively coupled plasma-mass spectrometry (ICP-MS) plasma optical emission spectrometer (ICP-OES). EC50 value strain response 38.08 mg/L. maximum biomass 0.26 g/L/d. GP revealed that low-level treatment could increase accumulation carrying capacity a culture. 154.00 μg/g DW. These findings lay groundwork understanding microalgal Se-containing nutraceuticals, offering valuable insights tolerance, dynamics, metabolic responses K-01.

Language: Английский

Citations

6
Loss of SELENOW aggravates muscle loss with regulation of protein synthesis and the ubiquitin-proteasome system DOI Creative Commons

Jia-Cheng Yang,

Meng Liu,

Rongkun Huang

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(38)

Published: Sept. 20, 2024

Sarcopenia is characterized by accelerated muscle mass and function loss, which burdens challenges public health worldwide. Several studies indicated that selenium deficiency associated with sarcopenia; however, the specific mechanism remains unclear. Here, we demonstrated selenoprotein W (SELENOW) containing in form of selenocysteine functioned sarcopenia. SELENOW expression up-regulated dexamethasone (DEX)–induced atrophy age-related sarcopenia mouse models. Knockout (KO) profoundly aggravated process loss two Mechanistically, KO suppressed RAC1-mTOR cascade interaction between RAC1 induced imbalance protein synthesis degradation. Consistently, overexpression vivo vitro alleviated myotube DEX. played a role regulated genes aging. Together, our study uncovered provides promising evidence for prevention treatment

Language: Английский

Citations

6
Selenium nanoparticles promotes intestinal development in broilers by inhibiting intestinal inflammation and NLRP3 signaling pathway compared with other selenium sources DOI Creative Commons
Yanhong Chen, Caiwei Luo, Shu Li

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(9), P. 103958 - 103958

Published: June 7, 2024

This study aimed to investigate how various selenium sources affect the intestinal health of broiler chickens. A total 384, one-day-old Arbor Acres broilers were weighed and randomly allocated four treatment groups. The control diet was a basal added with: 0.2 mg/kg Sodium Selenite (SS-control), Selenium nano-particles (Nano-Se), Selenomethionine (SeMet), Selenocysteine (Sec) as treatments. results indicated that Nano-Se SeMet effective in enhancing villus height (VH) height/crypt depth ratio (VH/CD) jejunum compared (SS) (P < 0.05). inclusion into diets increased mRNA levels zonula occluden-1 (ZO-1), ZO-2, Occludin, Claudin-1, Claudin-3 SS ZO-1 Moreover, upregulated marker genes enteroendocrine cells, stem epithelial cells However, supplementation reduced interleukin 1β (IL-1β), IL-8 concentration reactive oxygen species (ROS) also protein CAT SOD Sec number goblet Mucin-2 (Muc2) highest group expression cell differentiation regulator (v-myc avian myelocytomatosis viral oncogene homolog, c-Myc) decreased NLRP3 signaling pathway-related In conclusion, our demonstrated are better at improving 21-day-old broilers. Additionally, superior antioxidant anti-inflammatory effects, promoting development by modifying pathway.

Language: Английский

Citations

5
Poultry Nutrition: Achievement, Challenge and Strategy DOI
Kexin Cao,

Zhang‐Chao Deng,

Shijun Li

et al.

Journal of Nutrition, Journal Year: 2024, Volume and Issue: 154(12), P. 3554 - 3565

Published: Oct. 16, 2024

Language: Английский

Citations

5
Alpha-class glutathione S-transferases involved in the detoxification of aflatoxin B1 in ducklings DOI
Yu Zhang, Kexin Cao,

Qin-Jian Niu

et al.

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 174, P. 113682 - 113682

Published: Feb. 20, 2023

Language: Английский

Citations

12
Estimation of Protein and Amino Acid Requirements in Layer Chicks Depending on Dynamic Model DOI Creative Commons
Miao Liu, Zhiyuan Xia, Honglin Li

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(5), P. 764 - 764

Published: Feb. 29, 2024

Four trials were conducted to establish a protein and amino acid requirement model for layer chicks over 0–6 weeks by using the analytical factorization method. In trial 1, total of 90 one-day-old Jing Tint 6 with similar body weight selected determine growth curve, carcass feather deposition, patterns proteins. 2 3, 24 seven-day-old thirty-five-day-old maintenance requirements, pattern, net utilization rate. 4, ten-day-old thirty-eight-day-old standard terminal ileal digestibility acids. The fed either corn–soybean basal diet, low nitrogen or nitrogen-free diet throughout different trials. Gompertz equation showed that there is functional relationship between age, described as BWt(g) = 2669.317 × exp(−4.337 exp(−0.019t)). Integration test results gave comprehensive dynamic could accurately calculate weekly requirements chicks. By applying model, it was found during 6-week period 21.15, 20.54, 18.26, 18.77, 17.79, 16.51, respectively. model-predicted follows: Aspartic (0.992–1.284), Threonine (0.601–0.750), Serine (0.984–1.542), Glutamic (1.661–1.925), Glycine (0.992–1.227), Alanine (0.909–0.961), Valine (0.773–1.121), Cystine (0.843–1.347), Methionine (0.210–0.267), Isoleucine (0.590–0.715), Leucine (0.977–1.208), Tyrosine (0.362–0.504), Phenylalanine (0.584–0.786), Histidine (0.169–0.250), Lysine (0.3999–0.500), Arginine (0.824–1.147), Proline (1.114–1.684), Tryptophan (0.063–0.098). conclusion, this study constructed brooding period, providing an important insight improve precise feeding through calculation.

Language: Английский

Citations

4