A Review on Biosensors for Quantification of MCP‐1 as a Potential Biomarker in Diseases DOI

Zahra Jamalizadeh Bahaabadi,

Mohammad Javad Javid‐Naderi,

Prashant Kesharwani

et al.

Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

ABSTRACT Monocyte chemoattractant protein‐1 (MCP‐1) as a chemokine is essential for inflammation‐related processes. It regulates immunological responses and cell migration, which contribute to inflammation. Many disorders are exacerbated by this chemokine, attracts or grows other inflammatory cells, including monocytes/macrophages, at the site of infection tissue injury. The elevated concentrations MCP‐1 associated with pathogenesis many diseases, such cancer, cardiovascular disease, kidney neuroinflammatory disease. Therefore, monitoring biomarker in body has been recommended strongly advised make an accurate diagnosis prognosis. Although great importance disease processes, few biosensing approaches specifically designed detect molecule. These often electrochemical optical techniques. Rapid diseases identifying biomarkers had effect on advancement biosensors. Improved biosensor technology expansion prevents excessive prices low sensitivity, enabling quick correct tracking This review will concentrate biological functions MCP‐1, its significance different disorders, features applications biosensors detection quantification.

Language: Английский

Electrospinning-Based Biosensors for Health Monitoring DOI Creative Commons

Guojing Ji,

Zhou Chen, Hui Li

et al.

Biosensors, Journal Year: 2022, Volume and Issue: 12(10), P. 876 - 876

Published: Oct. 15, 2022

In recent years, many different biosensors are being used to monitor physical health. Electrospun nanofiber materials have the advantages of high specific surface area, large porosity and simple operation. These properties play a vital role in biosensors. However, mechanical electrospun nanofibers poor relative other techniques production. At same time, organic solvents electrospinning generally toxic expensive. Meanwhile, excellent performance brings about higher levels sensitivity detection range This paper summarizes principle application technology its comparison with technologies.

Language: Английский

Citations

38
Biosensors for waterborne virus detection: Challenges and strategies DOI Creative Commons
Xixi Song, Zina Fredj, Yuqiao Zheng

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2023, Volume and Issue: 13(11), P. 1252 - 1268

Published: Aug. 31, 2023

Waterborne viruses that can be harmful to human health pose significant challenges globally, affecting care systems and the economy. Identifying these waterborne pathogens is essential for preventing diseases protecting public health. However, handling complex samples such as wastewater challenging due their dynamic composition ultralow concentration of target analytes. This review presents a comprehensive overview latest breakthroughs in virus biosensors. It begins by highlighting several promising strategies enhance sensing performance optical electrochemical biosensors samples. These include optimizing bioreceptor selection, transduction elements, signal amplification, integrated systems. Furthermore, insights gained from biosensing are applied improve wastewater, with particular focus on sampling sample pretreatment dispersion characteristics wastewater. suggests implementing system integrates entire detection process high-accuracy analysis could monitoring. findings provide valuable improving effectiveness detection, which have implications environmental management.

Language: Английский

Citations

19
Adapted methods for monitoring influenza virus and respiratory syncytial virus in sludge and wastewater DOI Creative Commons
Daniel Toribio-Avedillo, Clara Gómez-Gómez, Laura Sala‐Comorera

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170636 - 170636

Published: Feb. 6, 2024

Wastewater-based surveillance constitutes a valuable methodology for the continuous monitoring of viral circulation, with capacity to function as an early warning system. It holds particular significance in scenarios where respiratory viruses exhibit overlapping clinical presentations, occurs SARS-CoV-2, influenza virus (IV), and syncytial (RSV), allows seasonal outbreaks be distinguished from COVID-19 peaks. Furthermore, sewage sludge, given it harbors concentrated human waste large population, serves substantial reservoir pathogen detection. To effectively integrate wastewater-based epidemiology into infectious disease surveillance, detection methods employed wastewater samples must adapted distinct characteristics sludge matrices. In this study, we applied protocols IV RSV comparing their performance results obtained wastewater. assess efficiency these protocols, were spiked RNA, either free or incorporated lentiviral particles. Samples using aluminum hydroxide adsorption-precipitation method before RNA extraction. Absolute quantification was carried out by RT-qPCR, including internal control monitor potential inhibitory factors. Recovery efficiencies both 60 % 75 71 respectively wastewater, whereas values particles 16 10 21 17 respectively. Additionally, protocol enabled naturally occurring collected two treatment plants during winter months, thus affirming efficacy methodologies.

Language: Английский

Citations

8
Interdisciplinary Approach to Monkeypox Prevention: Integrating Nanobiosensors, Nanovaccines, Artificial Intelligence, Visual Arts, and Social Sciences DOI Creative Commons
Vishal Chaudhary,

Lucky Lucky,

Harsh Sable

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

To effectively address crisis emergence of new virus such as monkeypox, a collective and collaborative effort between scientists, engineers, innovators, artists from all ages, regions, diverse fields is required. This review explores holistic approach to addressing the monkeypox by integrating nanobiosensors, artificial intelligence, visual arts, humanities, social sciences. Traditional diagnostic methods are often limited time, accessibility, accuracy, but advancement point‐of‐care smart nanobiosensors offers promising shift toward rapid, precise, accessible diagnostics. They enhance ability screen, diagnose, monitor infections efficiently, contributing better disease management. Beyond technological innovation, essential role sciences in fostering public engagement, understanding, acceptance tools emphasized. Visual arts can illustrate scientific concepts, making them more relatable, while storytelling through various media reduce stigma promote preventive measures. Social provide insights into cultural attitudes, behaviors, health challenges, ensuring that solutions integrated communities. By combining these disciplines, this presents comprehensive framework for resilient global system aligns with One Health principles, emphasizing interconnectedness human, animal, environmental health.

Language: Английский

Citations

1
Optimization of a 6-plex Crystal Digital PCR® assay and its application to simultaneous surveillance of enteric and respiratory viruses in wastewater DOI Creative Commons
Bikash Malla, Sadhana Shrestha, Eiji Haramoto

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 970, P. 178939 - 178939

Published: March 1, 2025

Multiplex digital PCR (dPCR) approaches are commonly employed in wastewater-based epidemiology (WBE) studies. However, optimizing the dPCR workflow is a critical step to ensure its reliability and accuracy before application. In this study, 6-plex Crystal Digital PCR® (cdPCR) was optimized for simultaneous detection of six epidemiologically important pathogens, including three enteric viruses, noroviruses genogroups I II (NoV-GI GII) enteroviruses (EnV), respiratory severe acute syndrome coronavirus 2 (SARS-CoV-2), which causative agent disease 2019 (COVID-19), influenza A virus (InfA), syncytial B (RSVB), wastewater. Four cDNA input ratios (20 %-70 %) two extraction kits were evaluated optimization, with 30 % AllPrep PowerViral DNA/RNA Kit (Qiagen) exhibiting optimal performance. The cdPCR assay applied year-long wastewater surveillance study Japan (n = 52), revealing distinct trends prevalence viruses. NoV-GII detected 96 samples highest mean concentration (6.1 ± 0.6 log10 copies/L), while SARS-CoV-2 InfA 60 50 samples, respectively, reflected circulation these pathogens within community. Notably, RSVB less frequently (25 %), line fewer cases reported during period. concentrations EnV showed significant positive correlations hand foot mouth herpangina cases, respectively. no observed RSV COVID-19, possibly due testing RSVA more prevalent also cluster outbreaks. These findings demonstrated utility detecting provided insights into community trends, representing an advancement WBE.

Language: Английский

Citations

1
Urine biomarkers for Alzheimer's disease: A new opportunity for wastewater-based epidemiology? DOI Creative Commons
Arnoldo Armenta-Castro,

Mónica T. Núñez-Soto,

Kassandra O. Rodríguez-Aguillón

et al.

Environment International, Journal Year: 2024, Volume and Issue: 184, P. 108462 - 108462

Published: Jan. 28, 2024

While Alzheimer's disease (AD) diagnosis, management, and care have become priorities for healthcare providers researcher's worldwide due to rapid population aging, epidemiologic surveillance efforts are currently limited by costly, invasive diagnostic procedures, particularly in low middle income countries (LMIC). In recent years, wastewater-based epidemiology (WBE) has emerged as a promising tool public health assessment through detection quantification of specific biomarkers wastewater, but applications non-infectious diseases such AD remain limited. This early review seeks summarize AD-related urine other peripheral biofluids discuss their potential integration WBE platforms guide the first prospective field. Promising results been reported clinical settings, indicating amyloid β, tau, neural thread protein, long non-coding RNAs, oxidative stress markers dysregulated metabolites questions regarding concentration stability wastewater correlation between levels sewage circulation must be addressed future studies before comprehensive systems can developed.

Language: Английский

Citations

6
Transforming early microbial detection: Investigating innovative biosensors for emerging infectious diseases DOI Creative Commons
Godfred Yawson Scott, Abdullahi Tunde Aborode, Ridwan Olamilekan Adesola

et al.

Advances in Biomarker Sciences and Technology, Journal Year: 2024, Volume and Issue: 6, P. 59 - 71

Published: Jan. 1, 2024

The recent global pandemic has highlighted an increase in the prevalence of communicable diseases caused by pathogens. swift transmission these within a short timeframe presents substantial risk to public health worldwide. inefficiency traditional diagnostic instruments, which need time-consuming and complex process laboratory, is significant obstacle medical care. Currently, there high for advancement early detection order rapidly diagnose infectious provide on-site results. This crucial prompt intervention improve treatment outcomes. also provides rapid testing high-quality microbiological detection, comparable laboratory standards, matter minutes. Prompt diagnosis subsequent optimization aid controlling spread diseases. ongoing techniques methods are used advancements through biosensors. review examines integration diagnostics with biosensors, specifically relation emerging re-emerging diseases, challenges, future perspective.

Language: Английский

Citations

6
Recent progress of functionalized nanomaterials-based biosensing for monitoring of food- and water-borne pathogens DOI

Piyush Dey,

Mohd. Jamshaiya Raza,

Alisha Khera

et al.

Environmental Nanotechnology Monitoring & Management, Journal Year: 2024, Volume and Issue: 21, P. 100914 - 100914

Published: Jan. 9, 2024

Language: Английский

Citations

4
Wastewater-born eviruses and bacteria, surveillance and biosensors at the interface of academia and field deployment DOI
Rajendra Singh, Jaewon Ryu, Woo Hyoung Lee

et al.

Critical Reviews in Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: July 7, 2024

Wastewater is a complex, but an ideal, matrix for disease monitoring and surveillance as it represents the entire load of enteric pathogens from local catchment area. It captures both clinical community burdens. Global interest in wastewater has been growing rapidly infectious diseases providing early warning potential outbreaks. Although molecular detection methods show high sensitivity specificity pathogen wastewater, they are strongly limited by challenges, including expensive laboratory settings prolonged sample processing analysis. Alternatively, biosensors exhibit wide range practical utility real-time biological chemical markers. However, field deployment primarily challenged concentration steps due to complex matrices. This review summarizes role provides overview viral bacterial with cutting-edge technologies their detection. emphasizes major bottlenecks pathogens, overcoming approaches Furthermore, promising novel machine learning algorithms resolve uncertainties data discussed.

Language: Английский

Citations

3
Optical Image Sensors for Smart Analytical Chemiluminescence Biosensors DOI Creative Commons
Reza Abbasi,

Xinyue Hu,

Alain Zhang

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(9), P. 912 - 912

Published: Sept. 12, 2024

Optical biosensors have emerged as a powerful tool in analytical biochemistry, offering high sensitivity and specificity the detection of various biomolecules. This article explores advancements integration optical with microfluidic technologies, creating lab-on-a-chip (LOC) platforms that enable rapid, efficient, miniaturized analysis at point need. These LOC leverage phenomena such chemiluminescence electrochemiluminescence to achieve real-time quantification analytes, making them ideal for applications medical diagnostics, environmental monitoring, food safety. Various detectors used detecting are reviewed, including single-point photomultiplier tubes (PMT) avalanche photodiodes (APD), pixelated charge-coupled devices (CCD) complementary metal-oxide-semiconductor (CMOS) sensors. A significant advancement discussed this review is image sensors, particularly CMOS sensors provide numerous advantages over traditional detectors, high-resolution imaging, spatially resolved measurements, ability simultaneously detect multiple analytes. Their compact size, low power consumption, cost-effectiveness further enhance their suitability portable point-of-care diagnostic devices. In future, machine learning algorithms these technologies promises data interpretation, driving development more sophisticated, accessible tools diverse applications.

Language: Английский

Citations

3