Mechanistic Insights on the Mechanosynthesis of Phenytoin, a WHO Essential Medicine** DOI Creative Commons
Francesco Puccetti, Stipe Lukin, Krunoslav Užarević

et al.

Chemistry - A European Journal, Journal Year: 2022, Volume and Issue: 28(13)

Published: Jan. 18, 2022

In recent years, mechanochemistry has enriched the toolbox of synthetic chemists, enabling faster and more sustainable access to new materials existing products, including active pharmaceutical ingredients (APIs). However, molecular-level understanding most mechanochemical reactions remains limited, delaying implementation in industrial applications. Herein, we have applied situ monitoring by Raman spectroscopy mechanosynthesis phenytoin, a World Health Organization (WHO) Essential Medicine, observation, isolation, characterization key molecular-migration intermediates involved single-step transformation benzil, urea, KOH into phenytoin. This work contributes elucidation reaction mechanism that been subjected number interpretations over time paints clear picture how can be optimized for preparation added-value molecules.

Language: Английский

Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions DOI Creative Commons
Federico Cuccu, Lidia De Luca, Francesco Delogu

et al.

ChemSusChem, Journal Year: 2022, Volume and Issue: 15(17)

Published: July 21, 2022

Mechanochemical transformations have made chemists enter unknown territories, forcing a different chemistry perspective. While questioning or revisiting familiar concepts belonging to solution chemistry, mechanochemistry has broken new ground, especially in the panorama of organic synthesis. Not only does it foster "thinking outside box", but also opened reaction paths, allowing overcome weaknesses traditional exactly where use well-established solution-based methodologies rules out progress. In this Review, reader is introduced an intriguing research subject not yet fully explored and waiting for improved understanding. Indeed, study mainly focused on that, although impossible solution, become possible under mechanochemical processing conditions, simultaneously entailing innovation expanding chemical space.

Language: Английский

Citations

193
Mechanochemical synthesis of metal oxide nanoparticles DOI Creative Commons
Takuya Tsuzuki

Communications Chemistry, Journal Year: 2021, Volume and Issue: 4(1)

Published: Oct. 12, 2021

In the last decades, mechanochemical processing has emerged as a sustainable method for large-scale production of variety nanomaterials. particular, synthesis can afford well-dispersed metal-oxide nanoparticles, which are used in wide-ranging applications including energy storage and conversion, environmental monitoring, or biomedical uses. This article reviews recent progress explores reaction mechanisms, contrasts influence chosen process parameters on properties end products. The role choice pathway, well advantages limitations compared to other methods discussed. A prospect future development this synthetic is proposed.

Language: Английский

Citations

133
Green metrics in mechanochemistry DOI Creative Commons

Nicolas Fantozzi,

Jean‐Noël Volle, Andrea Porcheddu

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(19), P. 6680 - 6714

Published: Jan. 1, 2023

The quantitative assessment of the greenness mechanochemical processes for green metrics were calculated is herein reported. A general introduction to topic, variables influencing reaction outcome and, an outlook are also provided.

Language: Английский

Citations

95
Mechanochemistry Can Reduce Life Cycle Environmental Impacts of Manufacturing Active Pharmaceutical Ingredients DOI
Or Galant,

Giacomo Cerfeda,

Aaron S. McCalmont

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2022, Volume and Issue: 10(4), P. 1430 - 1439

Published: Jan. 20, 2022

The scale-up of mechanochemical methods could play a transformative role in making manufacturing processes the pharmaceutical industry greener by eliminating solvent use and recovery. Combined with energy-efficient continuous processing that consolidates reaction steps, mechanochemistry's environmental economic benefits may translate across product supply chains. Here, we evaluate numerous sustainability green chemistry metrics for producing nitrofurantoin, an active ingredient (API), via twin-screw extrusion (TSE) conventional solvent-batch synthesis methods. We find significant reduction all TSE including energy, climate change, human ecological health, as well cost due to reducing excess reactant consumption solvents while maintaining high selectivity. In addition, replacing direct energy source drive chemical from mostly thermal electrical sources does not increase net life cycle consumed produce functionally equivalent API. conclude holds multiple APIs potentially other products.

Language: Английский

Citations

88
Tinkering with Mechanochemical Tools for Scale Up DOI Creative Commons
Javier F. Reynes, Valerio Isoni, Felipe Garcı́a

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(44)

Published: April 28, 2023

Mechanochemistry provides an environmentally benign platform to develop more sustainable chemical processes by limiting raw materials, energy use, and waste generation while using physically smaller equipment. A continuously growing research community has steadily showcased examples of beneficial mechanochemistry applications at both the laboratory preparative scale. In contrast solution-based chemistry, mechanochemical have not yet been standardized, thus scaling up is still a nascent discipline. The purpose this Minireview highlight similarities, differences challenges various approaches that successfully applied for range scales. We hope provide discussion starting point those interested in further developing commercial use and/or industrialisation.

Language: Английский

Citations

51
Beyond Solvothermal: Alternative Synthetic Methods for Covalent Organic Frameworks DOI Creative Commons
Ji‐Yun Hu, Zhiyuan Huang, Yi Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(37)

Published: June 2, 2023

Abstract Covalent organic frameworks (COFs) are crystalline porous materials that hold a wealth of potential applications across various fields. The development COFs, however, is significantly impeded by the dearth efficient synthetic methods. traditional solvothermal approach, while prevalent, fraught with challenges such as complicated processes, excessive energy consumption, long reaction times, and limited scalability, rendering it unsuitable for practical applications. quest simpler, quicker, more energy‐efficient, environmentally benign strategies thus paramount bridging gap between academic COF chemistry industrial application. This Review provides an overview recent advances in alternative methods, particular emphasis on input. We discuss representative examples synthesis facilitated microwave, ultrasound, mechanic force, light, plasma, electric field, electron beam. Perspectives advantages limitations these methods against approach highlighted.

Language: Английский

Citations

50
Mechanosynthesized electroactive materials for sustainable energy and environmental applications: A critical review DOI Creative Commons
Zhijie Chen, Gao‐Feng Han, Asif Mahmood

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 145, P. 101299 - 101299

Published: April 16, 2024

Electrochemistry-driven techniques for advanced energy storage/conversion and environmental protection play a crucial role in achieving sustainable development goals. As an indispensable component diverse electrochemical systems, electroactive materials gain soaring interest terms of rational design synthesis. Notably, mechanochemistry-based green powerful synthesis has been widely employed to fabricate materials, given their scalability tunability. Recently, mechanochemically synthesized have applied various fields, leading significant progress. However, systematic analysis these advancements is still missing. Herein, we comprehensively discuss recent achievements mechanosynthesized applications. The mechanochemical introduced, along with different types materials. Subsequently, the review delves into applications conversion/storage systems remediation. structure-performance correlation are illustrated by discussing effects process on internal external properties performance. Lastly, key perspectives this field discussed, including monitoring, field-assisted synthesis, material performance optimization, practical applications, mechanochemistry-driven fuels/chemicals By illustrating current advances related aims shed some light upcoming research synthesis-driven sustainability.

Language: Английский

Citations

31
Intermediates in Mechanochemical Reactions DOI
Karen J. Ardila‐Fierro, José G. Hernández

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(14)

Published: Jan. 5, 2024

Abstract Mechanochemical reactions offer methodological and environmental advantages for chemical synthesis, constantly attracting attention within the scientific community. Besides unmistakable sustainability advantages, conditions under which mechanochemical occur, namely solventless conditions, sometimes facilitate isolation of otherwise labile or inaccessible products. Despite these limited knowledge exists regarding mechanisms types intermediates involved. Nevertheless, in an expanding number cases, ex situ monitoring techniques have allowed observation, characterization, reaction transformations. In this Minireview, we present a series examples reactive been detected spanning organic, organometallic, inorganic, materials chemistry. Many were stabilized by non‐covalent interactions, played pivotal role guiding We believe that uncovering understanding such instances, growing mechanochemistry community could find novel opportunities catalysis discover new while achieving simplification design.

Language: Английский

Citations

29
Advances in Degradation Mechanism and Sustainable Recycling of LiFePO4-type Lithium-ion Batteries DOI

Cai Qi,

Tianshun Yao,

Wenjie Zhai

et al.

Energy storage materials, Journal Year: 2024, Volume and Issue: 71, P. 103623 - 103623

Published: July 14, 2024

Language: Английский

Citations

20
Mechanochemical Rearrangements DOI
David Virieux, Francesco Delogu, Andrea Porcheddu

et al.

The Journal of Organic Chemistry, Journal Year: 2021, Volume and Issue: 86(20), P. 13885 - 13894

Published: July 14, 2021

Molecular rearrangements are a powerful tool for constructing complex structures in an atom- and step-economic manner, translating multistep transformations into intrinsically more sustainable process. Mechanochemical molecular become even appealing eco-friendly synthetic approach, especially preparing active pharmaceutical ingredients (APIs) natural products. Still their infancy, promoted by mechanochemistry represent promising approach chemists to merge diversity green chemistry perspectives toward selective efficient syntheses with reduced environmental footprint.

Language: Английский

Citations

71