Post-acute COVID-19 syndrome and kidney diseases: what do we know?

Journal of Nephrology, Journal Year: 2022, Volume and Issue: 35(3), P. 795 - 805

Published: March 16, 2022

Language: Английский

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COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes

JAMA Internal Medicine, Journal Year: 2024, Volume and Issue: 184(4), P. 414 - 414

Published: Feb. 26, 2024

Importance COVID-19 infection is associated with a high incidence of acute kidney injury (AKI). Although rapid function decline has been reported in the first few months after COVID-19−associated AKI (COVID-AKI), longer-term association COVID-AKI remains unknown. Objective To assess long-term outcomes patients who had AKI. Design, Setting, and Participants This was retrospective longitudinal multicenter cohort study conducted large hospital system using electronic health records data on adult hospitalized or other illnesses. Included were during pandemic (March 2020-June 2022), screened for SARS-CoV-2, AKI, survived to discharge, 5 years before (October 2016-January 2020), positive influenza A B test result, discharge. Patients followed up maximum 2 Data analyses performed from December 2022 November 2023. Exposure influenza. Main Outcomes Measures The primary outcome major adverse events (MAKE), defined as composite mortality worsened (estimated glomerular filtration rate [eGFR] by ≥25% discharge eGFR failure requiring dialysis). Multivariable time-to-event compare MAKE between individuals those illnesses same period. For further comparison, this assessed historic influenza-associated Results included 9624 (mean [SD] age, 69.0 [15.7] years; 4955 [51.5%] females) including 987 COVID-AKI, 276 8361 (other-AKI). Compared groups, slightly younger higher baseline eGFR, worse comorbidity scores, markers illness severity, longer stay. other-AKI group, group lower (adjusted hazard ratio [aHR], 0.67; 95% CI, 0.59-0.75) due all-cause (aHR, 0.31; 0.24-0.39) rates 0.78; 0.69-0.88). Conclusions Relevance findings indicate that survivors hospitalization experience MAKE, decline, compared

Language: Английский

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Long term outcomes of patients with chronic kidney disease after COVID-19 in an urban population in the Bronx

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 19, 2025

Abstract We investigated the long-term kidney and cardiovascular outcomes of patients with chronic disease (CKD) after COVID-19. Our retrospective cohort consisted 834 CKD COVID-19 6,167 without between 3/11/2020 to 7/1/2023. Multivariate competing risk regression models were used estimate (as adjusted hazard ratios (aHR) 95% confidence intervals (CI)) progression a more advanced stage (Stage 4 or 5) major adverse events (MAKE), (MACE) at 6-, 12-, 24-month follow up. Hospitalized 12 24 months (aHR 1.62 CI[1.24,2.13] 1.76 [1.30, 2.40], respectively), but not non-hospitalized patients, higher compared those Both hospitalized MAKE 12- 24-months 1.73 [1.21, 2.50], 1.77 [1.34, 2.33], 1.31 [1.05, 1.64], MACE increases in CKD. These findings highlight need for close up care therapies that slow this high-risk subgroup.

Language: Английский

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Klotho-derived peptide KP1 ameliorates SARS-CoV-2-associated acute kidney injury

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 3, 2024

Introduction: The severe cases of COVID-19, a disease caused by acute respiratory syndrome coronavirus-2 (SARS-CoV-2), often present with kidney injury (AKI). Although old age and preexisting medical conditions have been identified as principal risk factors for COVID-19-associated AKI, the molecular basis behind such connection remains unknown. In this study, we investigated pathogenic role Klotho deficiency in AKI explored therapeutic potential Klotho-derived peptide 1 (KP1). Methods: We assessed susceptibility deficient Kl/Kl mice to developing after expression SARS-CoV-2 N protein. KP1 ameliorating tubular was using cultured proximal cells (HK-2) vitro mouse model ischemia-reperfusion (IRI) vivo . Results: Renal markedly downregulated various chronic (CKD) models aged mice. Compared wild-type counterparts, mutant KL/KL were susceptible overexpression protein developed lesions resembling AKI. , alone induced HK-2 express markers injury, cellular senescence, apoptosis epithelial-mesenchymal transition, whereas both abolished these lesions. Furthermore, mitigated dysfunction, alleviated inhibited IRI Conclusion: These findings suggest that is key determinant As such, KP1, small recapitulating function, could be an effective alleviating COVID-19 patients.

Language: Английский

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Predictors of Acute Kidney Injury (AKI) among COVID-19 Patients at the US Department of Veterans Affairs: The Important Role of COVID-19 Vaccinations

Vaccines, Journal Year: 2024, Volume and Issue: 12(2), P. 146 - 146

Published: Jan. 30, 2024

Background: There are knowledge gaps about factors associated with acute kidney injury (AKI) among COVID-19 patients. To examine AKI predictors patients, a retrospective longitudinal cohort study was conducted between January 2020 and December 2022. Logistic regression models were used to of AKI, survival analysis performed mortality in Results: A total 742,799 veterans diagnosed included 95,573 hospitalized within 60 days following diagnosis. 45,754 developed 28,573 patients hospitalized. Use vasopressors (OR = 14.73; 95% CL 13.96–15.53), history 2.22; 2.15–2.29), male gender 1.90; 1.75–2.05), Black race 1.62; 1.57–1.65), age 65+ 1.57; 1.50–1.63) AKI. Patients who vaccinated twice boosted least likely develop 0.51; 0.49–0.53) compared unvaccinated receiving two doses 0.77; 0.72–0.81), or single dose 0.88; 0.81–0.95) also less the unvaccinated. exhibited four times higher those without (HR 4.35; 4.23–4.50). Vaccinated had lowest risk 0.30; 0.28–0.31). Conclusion: vasopressors, being unvaccinated, older age, gender, post Whether vaccination, including boosters, decreases developing warrants additional studies.

Language: Английский

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Risk of kidney and liver diseases after COVID‐19 infection: A systematic review and meta‐analysis

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(2)

Published: March 1, 2024

Abstract COVID‐19 is not only associated with substantial acute liver and kidney injuries, but also an elevated risk of post‐acute sequelae involving the system. We aimed to investigate whether exposure increases long‐term disease, what are magnitudes these associations. searched PubMed, Embase, Web Science, ClinicalTrials.gov , Living Overview Evidence Repository for cohort studies estimating association between outcomes. Random‐effects meta‐analyses were performed combine results included studies. assessed certainty evidence using Grading Recommendations Assessment, Development Evaluation approach. Fifteen more than 32 million participants in systematic review was a 35% greater diseases (10 per 1000 persons; low evidence) 54% disease (3 evidence). The absolute due injury, chronic test abnormality 3, 8, 3 persons, respectively. Subgroup analyses found no differences different type diseases. findings provide further incident conditions. magnitude effect on outcomes was, however, relatively small.

Language: Английский

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Clinical implications of COVID-19 in chronic kidney disease and end-stage kidney disease

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 543 - 568

Published: Jan. 1, 2025

Language: Английский

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Subphenotypes of Long COVID and the clinical applications of probiotics

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117855 - 117855

Published: Jan. 24, 2025

Language: Английский

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Investigation of renal function in patients with long COVID in the Amazon region: a cross-sectional study

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 11, 2025

COVID-19 became a pandemic disease in 2020, with multisystem involvement and high renal morbidity during the acute phase. Some affected patients began to present new or persistent symptoms condition known as Long COVID. The study aimed evaluate function using clinical laboratory findings, establish frequency staging of decline COVID patients, well associated factors. This is cross-sectional observational that selected participants from care program between 2020 2022. A total 246 were for this study, was found 83 (33.7%). Patients over 60 years (29.6%) those who developed glycaemic alterations (41.8%) exhibited higher prevalence outcomes long test LDH levels glycated hemoglobin seems have statistic relation decrease (p < 0.05). common older age relevant condition. markers can be used predict outcome.

Language: Английский

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The Impact of Prior COVID-19 on Long-Term Mortality and Echocardiographic Predictors in Chronic Kidney Disease Patients

Diagnostics, Journal Year: 2025, Volume and Issue: 15(6), P. 678 - 678

Published: March 10, 2025

Background/Objectives: Chronic kidney disease (CKD) patients are at an increased risk for severe outcomes following a COVID-19 infection. However, the long-term impact of prior on survival in this population remains unclear. This study evaluates association between infection, echocardiographic parameters, and mortality CKD over 24-month follow-up period. Methods: A prospective cohort was conducted 239 patients, including those hemodialysis. Kaplan–Meier analysis Cox proportional hazards models were used to assess COVID-19, age, comorbidities rate. mediation examined role age parameters relationship. Results: curves demonstrated significantly lower probability group compared controls (72.5% vs. 87.1%, p = 0.01), particularly hemodialysis (62.5% 83.8%, 0.01). In contrast, no significant difference observed non-dialysis (p 0.52). multivariate confirmed as key mediator, with losing significance after adjustment 0.05). An identified left right ventricular dysfunction independent predictors, partially mediating COVID-19–mortality Conclusions: reduces rate while strong predictors mortality. Age mediates relationship mortality, but factor. These findings underscore need cardiac function monitoring post-COVID-19 improve outcomes.

Language: Английский

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