Ovarian function after COVID-19: long-term effects and vaccine safety in ART patients

Journal of Assisted Reproduction and Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

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SARS-CoV-2 and male infertility: from short- to long-term impacts

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 46(8), P. 1491 - 1507

Published: March 14, 2023

Language: Английский

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COVID-19 and metabolic syndrome

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 37(4), P. 101753 - 101753

Published: March 1, 2023

Language: Английский

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Birth rate decline in the later phase of the COVID-19 pandemic: the role of policy interventions, vaccination programmes and economic uncertainty

Human Reproduction Open, Journal Year: 2024, Volume and Issue: 2024(3)

Published: Jan. 1, 2024

Abstract STUDY QUESTION What are the factors influencing decline in birth rates observed higher-income countries later phase of COVID-19 pandemic? SUMMARY ANSWER Our results suggest that economic uncertainty, non-pharmaceutical policy interventions, and first wave population-wide vaccination campaign were associated with during 2022. WHAT IS KNOWN ALREADY During pandemic, most briefly declined then shortly recovered, showing no common trends afterwards until early 2022, when they unexpectedly dropped. DESIGN, SIZE, DURATION This study uses data on monthly total fertility (TFRs) adjusted for seasonality calendar effects provided Human Fertility Database (HFD). Births taking place between November 2020 October 2022 correspond to conceptions occurring February January i.e. after onset pandemic but prior Russian invasion Ukraine. The cover 26 countries, including 21 Europe, USA, Canada, Israel, Japan, Republic Korea. PARTICIPANTS/MATERIALS, SETTING, METHODS First, we a descriptive analysis changes TFR. Second, employed linear fixed regression models estimate association explanatory seasonally TFRs. considered three broader sets factors: interventions restricting mobility social activities outside home, progression programmes. MAIN RESULTS AND THE ROLE OF CHANCE We found as measured by increased inflation (P < 0.001), whereas unemployment did not show any link births = 0.677). stringency was linked postponement births, only lower institutional trust 0.003). In higher trust, stricter containment measures positively rates, both year 0.019) and, albeit weakly significant, 0.057). Furthermore, negative share population having received dose TFRs completed primary course (usually consisting two doses) recovery 0.001). LARGE SCALE DATA N/A. LIMITATIONS, REASONS FOR CAUTION research is restricted relatively strong support policies government well wide access modern contraception. allow analyses key characteristics, such age, order, status. WIDER IMPLICATIONS FINDINGS multi-country drivers pandemic. past, periods following epidemics health crises typically births. contrast, our gradual phasing out measures, allowing return more normal work life, contributed declining some countries. addition, indicates women avoided pregnancy completion protocol. FUNDING/COMPETING INTEREST(S) use external funding. authors acknowledge funding from their home institution, Vienna Institute Demography Austrian Academy Sciences, Open-Access Fund Sciences. For purpose open access, have applied CC BY public copyright licence Author Accepted Manuscript versions arising this submission. All declare conflicts interest.

Language: Английский

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Assisted reproductive technology in Japan: A summary report for 2021 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology

Reproductive Medicine and Biology, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 30, 2023

Abstract Purpose The Japan Society of Obstetrics and Gynecology (JSOG) registry gathers comprehensive data from registered assisted reproductive technology (ART) facilities in Japan. Herein, we report 2021 ART cycle characteristics outcomes. Methods Descriptive statistics were used to summarize analyze data. Results In 2021, 625 participated the registry; 27 did not conduct cycles 598 treatment cycles. total, 498 140 registered, there 69 797 neonates (increases 10.7% 15.5%, respectively, previous year). number freeze‐all vitro fertilization (IVF) intracytoplasmic sperm injection (ICSI) decreased 2021; born was 2268 for IVF‐embryo transfer (ET) 2850 ICSI Frozen–thawed ET (FET) increased markedly 2020 (11.2% increase). 239 428 FET conducted, resulting 87 174 pregnancies 64 679 neonates. For fresh transfers, total single ET, singleton pregnancy rate, live birth rates 82.7%, 97.0%, 97.3%; FET, these 84.9%, 96.9%, 97.1%. Conclusions Japanese analysis showed marked increases both births year.

Language: Английский

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Evaluation and management of male genital tract infections in the setting of male infertility: an updated review

Current Opinion in Urology, Journal Year: 2023, Volume and Issue: 33(3), P. 180 - 186

Published: March 2, 2023

Purpose of review Male infertility may be secondary to male genital tract infection (MGTI) in an estimated 15% cases. In the absence overt clinical signs, evaluation for MGTI beyond semen analysis is not well established. Therefore, we literature on and management setting infertility. Recent findings A set international guidelines recommends culture PCR testing, but significance positive results remains unclear. Clinical trials evaluating anti-inflammatory or antibiotic treatment report improvements sperm parameters leukocytospermia, data effect conception rates are lacking. Human papillomavirus (HPV) novel coronavirus (SARS-CoV-2) have been associated with poor decreased rates. Summary The finding leukocytospermia prompts further MGTI, including focused physical examination. role routine controversial. Treatment options include anti-inflammatories; frequent ejaculation; antibiotics, which should used symptoms microbiological infection. SARS-CoV-2 represents a subacute threat fertility that screened reproductive history along HPV other viruses.

Language: Английский

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Messenger RNA Therapy for Female Reproductive Health

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(2), P. 393 - 409

Published: Jan. 8, 2024

Female reproductive health has traditionally been an underrepresented area of research in the drug delivery sciences. This disparity is also seen emerging field mRNA therapeutics, a class medicines that promises to treat and prevent disease by upregulating protein expression body. Here, we review advances therapies through lens improving female health. Specifically, begin our discussing fundamental structure biochemical modifications associated with mRNA-based drugs. Then, discuss various packaging technologies, including lipid nanoparticles, can be utilized protect transport drugs target cells Last, conclude usage therapy for addressing pregnancy-related vaccination against sexually transmitted diseases women. Of note, highlight relevant clinical trials using while providing their corresponding National Clinical Trial identifiers. In undertaking this review, aim provide background understanding its specifically address issues overarching goal information toward gender certain aspects research.

Language: Английский

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A scoping review of global COVID-19 vaccine hesitancy among pregnant persons

npj Vaccines, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 20, 2024

Abstract Uptake of the COVID-19 vaccine among pregnant persons is lower than general population. This scoping review explored people’s attitudes towards vaccine, reasons for hesitancy, and whether about vaccines differ by country origin. A was conducted across PubMed, Embase, CINHAL, Scopus. Inclusion criteria were articles published in English from 2019–2022 focused on vaccination persons. Data analysis done via 5Cs framework hesitancy: Constraints, Complacency, Calculation, Confidence, Collective Responsibility. 44 extracted. lack confidence safety most prevalent theme hesitancy largely driven a access to information as well mistrust medical professionals. Meanwhile, acceptance mostly desire protect themselves their loved ones. Overall, continues be high. Vaccine primarily fear unknown side effects fetuses along with mistrust. Some differences can seen between high income low- middle-income countries regarding showing that single solution cannot applied all who are hesitant. General strategies, however, utilized reduce including advocating inclusion clinical trials incorporating consistent counseling during prenatal appointments.

Language: Английский

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COVID-19 Pharmacotherapy in Pregnancy: A Literature Review of Current Therapeutic Choices

Viruses, Journal Year: 2023, Volume and Issue: 15(3), P. 787 - 787

Published: March 19, 2023

The clinical management of COVID-19 in pregnant women, who are considered a vulnerable population, remains uncertain even as the pandemic subsides. SARS-CoV-2 affects individuals multiple ways and has been associated with severe maternal morbidity mortality, well neonatal complications. unique anatomy physiology gestation make managing this population complex challenging task, emphasizing importance spreading knowledge expertise area. Therapeutic interventions require distinct consideration, taking into account differences pharmacokinetics, vertical transmission, drug toxicities, postnatal care. Currently, there is limited data on antiviral immunomodulating pharmacotherapy pregnancy. Some medication shown to be safe tolerated among women COVID-19; however, lack randomized trials studies patient evident. Available vaccines effective, no evidence harm fetus, embryo development, or short-term development. Pregnant should counseled about risks infection informed available protect themselves their families. Effective treatments for not withheld from individuals, more research needed ensure best outcomes.

Language: Английский

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The effect of COVID‐19 and COVID‐19 vaccination on serum anti‐Mullerian hormone: A systematic review and meta‐analysis

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 1, 2024

The current study aims to evaluate the impact of COVID-19 infection and vaccination on ovarian reserve by detecting anti-Mullerian hormone (AMH) level.

Language: Английский

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