Die Gynäkologie, Journal Year: 2023, Volume and Issue: unknown
Published: Dec. 21, 2023
Contraception, Journal Year: 2025, Volume and Issue: unknown, P. 110829 - 110829
Published: Jan. 1, 2025
Language: Английский
Citations
1
BMJ Sexual & Reproductive Health, Journal Year: 2024, Volume and Issue: 50(3), P. 212 - 225
Published: June 10, 2024
Menstrual health is a key patient-reported outcome beyond its importance as general indicator of and fertility. However, menstrual function was not measured in the clinical trials COVID-19 vaccines. The purpose this review to synthesise existing literature on relationship between vaccination outcomes.
Language: Английский
Citations
8
Frontiers in Drug Safety and Regulation, Journal Year: 2024, Volume and Issue: 4
Published: Jan. 31, 2024
Introduction: Menstrual disorders are commonly reported after COVID-19 vaccination and heavy menstrual bleeding was added to the product information of vaccines Moderna Pfizer. The aim this review, using a systematic search, is provide an overview available literature on risk vaccination. Methods: review conducted according Preferred Reporting Items for Systematic reviews Meta-Analysis (PRISMA) guidelines. A PubMed search performed 15 August 2023, including solely quantitative studies in English Dutch. Results: total 61 were included, which 40 cross-sectional studies, 18 cohort three self-controlled case series. Outcomes included wide variety disorders, changes cycle length ( n = 54), amount 44), menses 30), experience (pre)menstrual pain 21), breakthrough 18). All found higher percentage at least one disorder first different types doses. Discussion: In conclusion, evidence suggests that may cause women reproductive age. However, there need more longitudinal because important limitations study designs many studies. Although short-lived predominantly mild, it healthcare professionals be informed about these potential adverse reactions assess events clinical trials vaccines.
Language: Английский
Citations
5
BMC Women s Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 18, 2025
Following a significant relaxation of restrictions in China on December 7, 2022, after surge SARS-CoV-2 infections, an uptick women presenting with menstrual disorders was observed clinics. This study aimed to explore the alterations characteristics and associated factors post infection. A cross-sectional online survey conducted among 869 non-amenorrheic adult Chinese females (aged 18–53) changes other infection-related initial The reported (group A) were compared no B). Data collected included basic individual-level information such as age, height, weight, history, reproductive disorders, chronic diseases, vaccination status, COVID-19 symptoms, (regularity, period volume, degree dysmenorrhea) Of participants, 442 (50.9%, group at least one characteristic; 171 (19.7%) experienced extended cycle, 122 (14.0%) decrease volume. Participants who more likely have pre-existing diseases (7.7% vs. 3.0%, P = 0.003) exhibit symptoms during acute (4.94 4.03, < 0.001) recovery (4.37 3.41, phases. These participants also report fever symptom (93.4% 86.9%, longer duration (2.25 1.96 days, B. Notably, fewer vaccine doses, COVID-19-related frequent (P 0.05) than may experience infection according self-report results this study.
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(7), P. e0306491 - e0306491
Published: July 25, 2024
Despite the importance of menstruation and menstrual cycle to health, human rights, sociocultural economic wellbeing, study health suffers from a lack funding, research remains fractured across many disciplines. We sought systematically review validated approaches measure four aspects changes cycle—bleeding, blood, pain, perceptions—caused by any source used within field. then evaluated quality utility for clinical trials identified instruments. searched MEDLINE, Embase, instrument databases included peer-reviewed articles published between 2006 2023 that reported on development or validation instruments assessing using quantitative mixed-methods methodology. From total 8,490 articles, 8,316 were excluded, yielding 174 reporting 94 Almost half United States Kingdom over only in English, Spanish, French, Portuguese. Most measured bleeding parameters, uterine perceptions, but few assessed characteristics blood. Nearly 60% developed populations with gynecologic disorders symptoms. had fair good trial utility; however, most lacked evidence responsiveness, question sensitivity and/or transferability, three scores both utility. Although we took novel, transdisciplinary approach, our systematic found important gaps literature landscape, pointing towards need examine more comprehensive, inclusive, standardized way. Our findings can inform new modified instruments, which—if fields trials—can contribute systemic holistic understanding cycle.
Language: Английский
Citations
2
Pharmacoepidemiology and Drug Safety, Journal Year: 2024, Volume and Issue: 33(8)
Published: Aug. 1, 2024
ABSTRACT Background Reports of adverse menstrual events emerged during the COVID‐19 vaccination campaign in multiple countries. This raised question whether these reports were caused by vaccines. The aim this systematic review was to evaluate comparative studies on topic (registered at PROSPERO [CRD42022324973]). Methods We included observational such as cohort and surveys comparing response self‐reported questionnaires between post‐ versus pre‐vaccination data. PubMed Cochrane Library searches conducted 1 September 2023. primary outcome incidence any prespecified event, measure risk ratio. meta‐analysis using Mantel–Haenszel method random effects model. summarized results factors well key findings included. Results retrieved 161 references from electronic databases additional sources lists. Of those, we considered 21 studies. event reported 12 resulted a pooled estimate (risk ratio 1.13; 95% CI, 0.96–1.31) that did not favor group. analysis constrained considerable clinical statistical heterogeneity. Risk for changes history infection, concern about vaccines, smoking, previous cycle irregularities, depression, stress, other issues. Conclusions group heterogeneity prevalent among Most suggested temporary, minor, nonserious.
Language: Английский
Citations
2
Obstetrics and Gynecology, Journal Year: 2023, Volume and Issue: unknown
Published: Dec. 7, 2023
OBJECTIVE: To quantitatively evaluate the effect of a booster vaccination dose against coronavirus disease 2019 (COVID-19) on menstrual cycle in large-scale retrospective cohort study using tracking smartphone application (app). METHODS: Prospectively or retrospectively recorded data, including start and finish dates cycles, were collected with app. Detailed data vaccinations, side effects, participants' characteristics from questionnaire For each COVID-19 shot (first, second, third), within-individual changes length up to fourth postvaccination evaluated. RESULTS: Among 7,376 6,873 participants who had first second vaccine doses different respectively, cycles immediately after (first cycles) an average 0.22 days (95% CI, 0.06–0.39) 0.37 0.20–0.54) longer than prevaccination cycle. In contrast, among 1,672 received same cycle, was 4.21 3.69–4.72) longer. The returned level However, 4,768 third dose, 1.20 1.00–1.40) longer, prolongation 0.27 0.10–0.44) 0.41 0.22–0.59) persisting CONCLUSION: may have greater longer-lasting primary-series shots. Although size small, evidence effects immunization menstruation should be accumulated.
Language: Английский
Citations
6
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: April 5, 2024
ABSTRACT Despite the importance of menstruation and menstrual cycle to health, human rights, sociocultural economic wellbeing, study health suffers from a lack funding, research remains fractured across many disciplines. We sought systematically review validated approaches measure four aspects changes cycle—bleeding, blood, pain, perceptions—caus ed by any source used within field. then evaluated quality utility for clinical trials identified instruments. searched MEDLINE, Embase, instrument databases included peer-reviewed articles published between 2006 2023 that reported on development or validation instruments assessing using quantitative mixed-methods methodology. From total 8,490 articles, 8,316 were excluded, yielding 174 reporting 94 Almost half United States Kingdom over only in English, Spanish, French, Portuguese. Most measured bleeding parameters, uterine perceptions, but few assessed characteristics blood. Nearly 60% developed populations with gynecologic disorders symptoms. had fair good trial utility; however, most lacked evidence responsiveness, question sensitivity and/or transferability, three scores both utility. Although we took novel, transdisciplinary approach, our systematic found important gaps literature landscape, pointing towards need examine more comprehensive, inclusive, standardized way. Our findings can inform new modified instruments, which—if fields trials—can contribute systemic holistic understanding cycle.
Language: Английский
Citations
1
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: April 5, 2024
Abstract Objective We sought to develop consensus recommendations for improved measurement of contraceptive-induced menstrual changes (CIMCs) in contraceptive clinical trials build upon previous standardization efforts. Study Design undertook a virtual consensus-building process using modified Delphi approach, incorporating aspects Nominal Group Technique and the Jandhyala method. The consisted four half-day meetings, developing within five topical working groups, series questionnaires assess recommendation agreement on 4-point Likert-like scale, opportunities input feedback throughout process. Recommendations required at least 75% be included. Results Our interdisciplinary group—from 26 organizations 13 countries global regions across academia, nonprofit research organizations, pharmaceutical industry, funding agencies— developed 44 recommendations. These included standardization, patient-reported outcome measure development aligned with current regulatory guidance, trial design, protocol development, participant recruitment, data collection, analysis, areas exploratory research. Seven were deemed priority by over 85% our group. Conclusion Using formal process, we reached high levels around more standardized patient-centered CIMCs trials, now future. Implications statement Consensus measuring bleeding related outcomes can improve reporting standardized, future product labeling. improvements enable providers offer relevant counseling contraceptives permit greater comparability synthesis inform guidance.
Language: Английский
Citations
1
Vaccine, Journal Year: 2024, Volume and Issue: 42(25), P. 126130 - 126130
Published: July 14, 2024
Several studies described that COVID-19 vaccinations can cause menstrual disorders. Our study aimed to describe whether this also resulted in more general practitioner (GP) consultations for disorders after vaccination, based on a large cohort study.
Language: Английский
Citations
1