Frontiers in Neuroscience,
Journal Year:
2022,
Volume and Issue:
16
Published: Sept. 7, 2022
Background
To
date,
the
clinical
need
for
therapeutic
methods
to
prevent
traumatic
spinal
cord
injury
(TSCI)
progression
and
improve
functional
recovery
has
not
been
met.
High
mobility
group
box-1
(HMGB1)
is
released
by
necrotic
neurons
or
secreted
glial
cells
after
TSCI
plays
an
important
role
in
pathophysiology.
Objective
The
purpose
of
this
study
was
evaluate
effects
HMGB1-targeted
therapy
on
locomotor
function
recovery,
inflammation
reduction,
edema
attenuation,
apoptosis
reduction
rat
mouse
models
TSCI.
Methods
We
reviewed
literature
treatment
prognosis
Twelve
articles
were
identified
analyzed
from
four
online
databases
(PubMed,
Web
Science,
Cochrane
Library
Embase)
based
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
(PRISMA)
guidelines
strict
inclusion
criteria.
Results
methodological
quality
12
poor.
results
meta-analysis
showed
that
compared
with
SCI
group,
had
significantly
increased
scores
[
n
=
159,
standardized
mean
difference
(SMD)
2.31,
95%
confidence
interval
(CI)
(1.52,
3.10),
P
<
0.00001],
change
both
drug
anti-HMGB1
Ab
groups
(
0.000001
0.000001).
A
subgroup
analysis
significant
differences
>
0.05)
between
[(SMD)
1.95,
CI
(0.95,
2.94),
0.0001]
2.89,
(1.66,
4.13),
0.00001].
Compared
HMGB1
expression
diminished
76,
SMD
−2.31,
(−3.71,
−0.91),
0.001],
TNF-α
levels
reduced
−2.52,
(−3.77,
−1.27),
0.0001],
water
content
44,
−3.94,
(−6.28,
−1.61),
0.0009],
number
apoptotic
36,
−3.31,
(−6.40,
−0.22),
0.04]
group.
Conclusion
improves
function,
reduces
inflammation,
attenuates
edema,
rats
mice
Intrathecal
injection
0-3
h
may
be
most
efficacious
treatment.
review
registration
PROSPERO,
identifier:
CRD42022326114.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(6), P. 1155 - 1155
Published: June 6, 2024
Licorice
(Glycyrrhiza
glabra)
is
a
plant
of
the
genus
Glycyrrhiza
in
family
Fabaceae/Leguminosae
and
renowned
natural
herb
with
long
history
medicinal
use
dating
back
to
ancient
times.
Glycyrrhizin
(GLY),
main
active
component
licorice,
serves
as
widely
utilized
therapeutic
agent
clinical
practice.
GLY
exhibits
diverse
properties,
including
anti-inflammatory,
antibacterial,
antiviral,
antitumor,
immunomodulatory,
intestinal
environment
maintenance,
liver
protection
effects.
However,
current
research
primarily
emphasizes
GLY’s
antiviral
activity,
while
providing
limited
insight
into
its
antibacterial
properties.
demonstrates
broad
spectrum
activity
via
inhibiting
growth
bacteria
by
targeting
bacterial
enzymes,
impacting
cell
membrane
formation,
altering
permeability.
Moreover,
can
also
bolster
host
immunity
activating
pertinent
immune
pathways,
thereby
enhancing
pathogen
clearance.
This
paper
reviews
inhibitory
mechanisms
against
various
pathogenic
bacteria-induced
pathological
changes,
role
high-mobility
group
box
1
inhibitor
regulation,
efficacy
combating
diseases
caused
bacteria.
Furthermore,
combining
other
antibiotics
reduces
minimum
concentration,
potentially
aiding
development
combination
therapies
drug-resistant
Sources
information
were
searched
using
PubMed,
Web
Science,
Science
Direct,
GreenMedical
for
keywords
“licorice”,
“Glycyrrhizin”,
“antibacterial”,
“anti-inflammatory”,
“HMGB1”,
combinations
thereof,
mainly
from
articles
published
1979
2024,
no
language
restrictions.
Screening
was
carried
out
one
author
supplemented
others.
Papers
experimental
flaws
their
design
papers
that
did
not
meet
expectations
(antifungal
papers,
etc.)
excluded.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(19), P. 10988 - 10988
Published: Sept. 20, 2022
Type
2
diabetes
mellitus
(T2DM)
is
a
chronic
metabolic
disease,
which
characterized
by
hyperglycemia,
insulin
resistance,
progressive
decline
in
β-cell
function,
and
defect
secretion.
It
has
become
one
of
the
leading
causes
death
worldwide.
At
present,
there
no
cure
for
T2DM,
but
it
can
be
treated,
blood
glucose
levels
controlled.
been
reported
that
diabetic
patients
may
suffer
from
adverse
effects
conventional
medicine.
Therefore,
alternative
therapy,
such
as
traditional
Chinese
medicine
(TCM),
used
to
manage
treat
diabetes.
In
this
review,
glycyrrhizic
acid
(GL)
its
derivatives
are
suggested
promising
candidates
treatment
T2DM
complications.
principal
bioactive
constituent
licorice,
type
TCM.
This
review
comprehensively
summarized
therapeutic
related
mechanisms
GL
managing
treating
addition,
also
discusses
existing
clinical
trials
highlights
research
gap
research.
summary,
provide
further
understanding
well
complications
recent
progress
development
potential
drugs
targeting
T2DM.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 17, 2025
Trichophyton
mentagrophytes
(T.
mentagrophytes)
is
a
prevalent
pathogen
that
causes
human
and
animal
dermatophytosis.
The
clinical
treatment
of
the
infections
challenging
due
to
prolonged
duration,
limited
efficacy,
antifungal
resistance
side
effects
existing
drugs.
Modern
research
has
reported
classic
Traditional
Chinese
medicine
(TCM)
prescription
Huangqin
decoction
(HQD)
along
with
its
principal
ingredients
could
exhibit
properties.
Given
valued
advantages
TCM
such
as
broad-spectrum
activity,
low
incidence
drug
toxicity,
this
study
investigated
activity
HQD
against
T.
explored
potential
inhibitory
mechanism,
aimed
provide
new
clues
for
By
detecting
minimal
concentration
(MIC)
using
broth
microdilution
method,
results
showed
significantly
inhibit
growth
mentagrophytes,
3.13
mg/mL.
transcriptome
sequencing
quantitative
real-time
PCR
(qRT-PCR)
technology
were
combined
shed
light
on
complicated
adaptive
responses
upon
HQD.
demonstrated
at
MIC,
compared
control
group,
total
730
differentially
expressed
genes
(DEGs)
detected
in
after
exposure
(FDR
adjusted
p-value
<
0.05),
which
547
up-regulated
183
down-regulated.
These
DEGs
abundant
"single-organism
metabolic
process",
"catalytic
activity"
"oxidoreductase
activity",
enriched
seven
signaling
pathways
including
glutathione
metabolism,
DNA
replication,
glyoxylate
dicarboxylate
taurine
hypotaurine
carotenoid
biosynthesis,
ubiquitin-mediated
proteolysis,
cyanoamino
acid
metabolism.
profiling
verified
qRT-PCR
subset
10
DEGs.
overall
evidence
indicated
had
significant
anti-dermatophyte
might
be
related
targeting
S-transferase
(GST)
gene
conjugate
toxic
xenobiotics
defense
oxidative
stress,
inhibition
replication
pathway
by
downgrading
licensing
factors
MCM3,
MCM5
ribonuclease
H1
(RNaseH1)
genes,
repressed
expression
phosphatidylserine
decarboxylase
(PSD)
phospholipid
synthesis
was
indispensable
hyphal
morphology,
differentiation
cell
wall
integrity.
Our
theoretical
basis
effective
infection
effect
fungi,
are
expected
offer
aids
discovering
agents
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 12, 2023
High
mobility
group
box
1
(HMGB1)
has
dual
functions
as
a
nonhistone
nucleoprotein
and
an
extracellular
inflammatory
cytokine.
In
the
resting
state,
HMGB1
is
mainly
located
in
nucleus
regulates
key
nuclear
activities.
After
spinal
cord
injury,
rapidly
expressed
by
neurons,
microglia
ependymal
cells,
it
either
actively
or
passively
released
into
matrix
blood
circulation;
furthermore,
also
participates
pathophysiological
process
of
injury.
can
regulate
activation
M1
microglia,
exacerbate
response,
expression
factors
through
Rage
TLR2/4,
resulting
neuronal
death.
However,
some
studies
have
shown
that
beneficial
for
survival,
regeneration
differentiation
neurons
promotes
recovery
motor
function.
This
article
reviews
specific
timing
secretion
translocation,
release
mechanism
role
Furthermore,
injury
and,
challenges
still
need
to
be
addressed
are
identified,
this
work
will
provide
basis
future
studies.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 18, 2023
HMGB1
that
belongs
to
the
High
Mobility
Group-box
superfamily,
is
a
nonhistone
chromatin
associated
transcription
factor.
It
present
in
nucleus
of
eukaryotes
and
can
be
actively
secreted
or
passively
released
by
kinds
cells.
important
for
maintaining
DNA
structure
binding
histones,
protecting
it
from
damage.
also
regulates
interaction
between
histones
DNA,
affecting
packaging,
influence
gene
expression
promoting
nucleosome
sliding.
And
as
DAMP,
RAGE
TLRs
activates
NF-κB,
which
triggers
downstream
genes
like
IL-18,
IL-1β,
TNF-α.
known
involved
numerous
physiological
pathological
processes.
Recent
studies
have
demonstrated
significance
DAMPs
female
reproductive
system.
These
findings
shed
light
on
potential
role
pathogenesis
diseases
system
possibilities
HMGB1-targeted
therapies
treating
them.
Such
help
reduce
inflammation
metabolic
dysfunction
alleviate
symptoms
diseases.
Overall,
identification
key
player
disease
represents
significant
breakthrough
our
understanding
these
conditions
presents
exciting
opportunities
development
novel
therapies.
